INT108173

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Context Info
Confidence 0.75
First Reported 2002
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 14
Total Number 21
Disease Relevance 8.61
Pain Relevance 4.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abcb1b) mitochondrion (Abcb1b) ATPase activity (Abcb1b)
Anatomy Link Frequency
SK-MEL-3 5
HTC 3
HeLa 2
spinal 1
liver 1
Abcb1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
induced neuropathy 4 99.80 Very High Very High Very High
vincristine 16 99.42 Very High Very High Very High
Morphine 22 99.24 Very High Very High Very High
Hippocampus 4 98.56 Very High Very High Very High
narcan 24 98.48 Very High Very High Very High
Paracetamol 6 98.42 Very High Very High Very High
Bile 16 95.88 Very High Very High Very High
Taxol 8 81.84 Quite High
imagery 12 77.40 Quite High
antagonist 2 61.44 Quite High
Disease Link Frequency Relevance Heat
Cancer 312 99.98 Very High Very High Very High
Neuropathic Pain 6 99.80 Very High Very High Very High
Hepatocellular Cancer 8 99.74 Very High Very High Very High
Gallstones 4 99.18 Very High Very High Very High
Shock 80 98.64 Very High Very High Very High
Liver Disease 4 98.64 Very High Very High Very High
Overdose 2 98.60 Very High Very High Very High
Drug Induced Neurotoxicity 4 97.44 Very High Very High Very High
Plasmacytoma 16 95.84 Very High Very High Very High
Osteogenic Sarcomas 8 95.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of the Mrd1a and Mdr1b genes encoding the P-glycoprotein (P-gp) also increased in the whole hippocampus and cortex of morphine-treated rats.
Gene_expression (expression) of P-glycoprotein in cortex associated with hippocampus and morphine
1) Confidence 0.75 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18761714 Disease Relevance 0 Pain Relevance 0.66
In vitro experiments by using human multidrug resistance 1 (MDR1)/P-gp overexpressing HeLa cells showed that the uptake of naloxone by the cells did not change in the presence of the P-gp inhibitors.
Gene_expression (overexpressing) of MDR1 in HeLa associated with narcan
2) Confidence 0.55 Published 2010 Journal J Pharm Sci Section Abstract Doc Link 19530072 Disease Relevance 0 Pain Relevance 0.49
Detection of the p-glycoprotein by western blot analysis corresponded to the results of mdr1 expression by RT-PCR (data not shown).
Gene_expression (expression) of mdr1
3) Confidence 0.51 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2903950 Disease Relevance 0.55 Pain Relevance 0
Among the main causes for failure of treatment is the resistance of tumor cells against the action of cytostatic drugs, which is based on the expression of certain genes such as the multidrug resistance gene (mdr1), coding for the p-glycoprotein (p-gp) [5].
Gene_expression (expression) of mdr1 associated with cancer
4) Confidence 0.51 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2903950 Disease Relevance 0.49 Pain Relevance 0.04
In vitro experiments by using human multidrug resistance 1 (MDR1)/P-gp overexpressing HeLa cells showed that the uptake of naloxone by the cells did not change in the presence of the P-gp inhibitors.
Gene_expression (overexpressing) of multidrug resistance 1 in HeLa associated with narcan
5) Confidence 0.48 Published 2010 Journal J Pharm Sci Section Abstract Doc Link 19530072 Disease Relevance 0 Pain Relevance 0.50
It is concluded that the hepatic expression of mdr1b is increased in the experimental liver diseases when compared to controls.
Gene_expression (expression) of mdr1b in liver associated with liver disease
6) Confidence 0.48 Published 2002 Journal Acta Gastroenterol. Latinoam. Section Abstract Doc Link 12553158 Disease Relevance 0.71 Pain Relevance 0.34
[Paracetamol overdose and experimental cholestasis induced gene expression regulation that codified P-Glycoprotein type 1 in rats].
Gene_expression (codified) of P-Glycoprotein type 1 associated with paracetamol, gallstones and overdose
7) Confidence 0.42 Published 2002 Journal Acta Gastroenterol. Latinoam. Section Title Doc Link 12553158 Disease Relevance 0.63 Pain Relevance 0.36
Cytostatic pretreatment can also be correlated with the presence of mdr1-mRNA and p-gp in the SK-MEL-3 tumor because the incidence of mdr1 expression has been observed to increase following previous chemotherapy, for example, in acute myeloic leucemia, plasmocytoma, or osteosarcoma, and adversely influences adversely remission rate and prognosis of relapsed tumors [21].
Gene_expression (expression) of mdr1 in SK-MEL-3 associated with plasmacytoma, cancer and osteogenic sarcomas
8) Confidence 0.39 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2903950 Disease Relevance 1.12 Pain Relevance 0
The untreated SK-MEL-3 tumor expressed mdr1, mrp1, and lrp, but not mrp2.
Neg (not) Gene_expression (expressed) of mdr1 in SK-MEL-3 associated with cancer
9) Confidence 0.39 Published 2010 Journal Journal of Oncology Section Abstract Doc Link PMC2903950 Disease Relevance 0.83 Pain Relevance 0
The SK-MEL-3 tumor constitutively expressed mdr1, mrp1, and lrp.
Gene_expression (expressed) of mdr1 in SK-MEL-3 associated with cancer
10) Confidence 0.39 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2903950 Disease Relevance 1.06 Pain Relevance 0
Expression of the chemoresistance genes mdr1, mrp1, mrp2, and lrp and of heat shock protein 72 (HSP72) in the tumor tissue was analysed using RT-PCR and western blot analysis.
Spec (analysed) Gene_expression (Expression) of mdr1 associated with cancer and shock
11) Confidence 0.39 Published 2010 Journal Journal of Oncology Section Abstract Doc Link PMC2903950 Disease Relevance 0.86 Pain Relevance 0
Expression of Chemoresistance Genes

Mdr1, mrp1, and lrp were constantly expressed in the untreated SK-MEL-3 tumor, whereas mrp2-mRNA could not be detected in any of the untreated tumor samples.

Gene_expression (expressed) of Mdr1 in SK-MEL-3 associated with cancer
12) Confidence 0.34 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2903950 Disease Relevance 0.40 Pain Relevance 0.04
Expression of Chemoresistance Genes

Mdr1, mrp1, and lrp were constantly expressed in the untreated SK-MEL-3 tumor, whereas mrp2-mRNA could not be detected in any of the untreated tumor samples.

Gene_expression (Expression) of Mdr1 in SK-MEL-3 associated with cancer
13) Confidence 0.34 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2903950 Disease Relevance 0.40 Pain Relevance 0.04
The expression of the Mrd1a and Mdr1b genes encoding the P-glycoprotein (P-gp) also increased in the whole hippocampus and cortex of morphine-treated rats.
Gene_expression (expression) of P-glycoprotein in hippocampus associated with hippocampus and morphine
14) Confidence 0.26 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18761714 Disease Relevance 0 Pain Relevance 0.66
The P(app) values of TSB in the BL-AP direction were significantly higher in MDCKII cells over-expressing MDR1 or MRP1, but not in cells over-expressing MRP2-5, as compared with the wild-type cells.
Neg (not) Gene_expression (expressing) of MDR1
15) Confidence 0.20 Published 2007 Journal Xenobiotica Section Abstract Doc Link 17455112 Disease Relevance 0.10 Pain Relevance 0.08
In hepatoma HTC-R cells overexpressing MDR1 protein, an increase in the whole-cell current (carried not only by ATP but also by Cl?)
Gene_expression (overexpressing) of MDR1 in HTC associated with hepatocellular cancer
16) Confidence 0.10 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096548 Disease Relevance 0.28 Pain Relevance 0
The same group later reported that MDR1-overexpressing cells (HTC-R and NIH3T3/MDR1) exhibited an approx. three-fold higher level of ATP release which was sensitive to the MDR inhibitors cyclosporin and verapamil [70].
Gene_expression (overexpressing) of MDR1 in HTC
17) Confidence 0.10 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096548 Disease Relevance 0.26 Pain Relevance 0
The same group later reported that MDR1-overexpressing cells (HTC-R and NIH3T3/MDR1) exhibited an approx. three-fold higher level of ATP release which was sensitive to the MDR inhibitors cyclosporin and verapamil [70].
Gene_expression (overexpressing) of MDR1 in HTC
18) Confidence 0.09 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096548 Disease Relevance 0.26 Pain Relevance 0
Indeed, Abraham et al. [66] observed enhanced release of ATP from CHO cells overexpressing a P-glycoprotein, murine MDR1, in a manner dependent on the amount of the expressed protein.
Gene_expression (overexpressing) of MDR1
19) Confidence 0.09 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096548 Disease Relevance 0 Pain Relevance 0.04
The results showed higher expression of mdr1a and mdr1b genes (x3 and x35, respectively) in the brain than in the spinal ganglia in both control and treated animals.
Gene_expression (expression) of mdr1b in spinal
20) Confidence 0.03 Published 2005 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 16221289 Disease Relevance 0.33 Pain Relevance 0.54

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