INT108202

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Context Info
Confidence 0.67
First Reported 2003
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 47
Total Number 49
Disease Relevance 25.83
Pain Relevance 8.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PIK3CG) plasma membrane (PIK3CG) cytoplasm (PIK3CG)
Anatomy Link Frequency
cleavage 2
macrophages 1
skeletal muscle cells 1
nucleus 1
monocyte 1
PIK3CG (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 28 100.00 Very High Very High Very High
COX2 6 99.66 Very High Very High Very High
Kappa opioid receptor 3 99.28 Very High Very High Very High
Morphine 20 99.04 Very High Very High Very High
qutenza 11 98.88 Very High Very High Very High
agonist 51 98.86 Very High Very High Very High
opioid receptor 16 98.68 Very High Very High Very High
cytokine 150 98.48 Very High Very High Very High
metalloproteinase 189 98.36 Very High Very High Very High
cINOD 44 98.06 Very High Very High Very High
Disease Link Frequency Relevance Heat
Multiple Myeloma 184 100.00 Very High Very High Very High
Cancer 795 99.88 Very High Very High Very High
Apoptosis 793 99.82 Very High Very High Very High
Breast Cancer 158 99.82 Very High Very High Very High
Adhesions 52 99.80 Very High Very High Very High
Lung Cancer 69 99.76 Very High Very High Very High
Drug Induced Neurotoxicity 20 99.70 Very High Very High Very High
Pancreatic Cancer 77 99.64 Very High Very High Very High
Left Ventricular Hypertrophy 48 99.18 Very High Very High Very High
Stress 164 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Capsaicin induces heme oxygenase-1 expression in HepG2 cells via activation of PI3K-Nrf2 signaling: NAD(P)H:quinone oxidoreductase as a potential target.
Positive_regulation (activation) of PI3K associated with qutenza
1) Confidence 0.67 Published 2007 Journal Antioxid. Redox Signal. Section Title Doc Link 17979524 Disease Relevance 0 Pain Relevance 0.90
We also examined the levels of intracellular reactive oxygen species (ROS) and activation of PI3K/Akt signaling pathway.
Spec (examined) Positive_regulation (activation) of PI3K
2) Confidence 0.67 Published 2010 Journal Neurotoxicology Section Body Doc Link 19879292 Disease Relevance 0.17 Pain Relevance 0
BV increased the number of melanocytes dose and time dependently through PKA, ERK, and PI3K/Akt activation.
Positive_regulation (activation) of PI3K in melanocytes
3) Confidence 0.67 Published 2007 Journal Exp. Mol. Med. Section Abstract Doc Link 18059136 Disease Relevance 0.24 Pain Relevance 0.20
We found that DPDPE-triggered monocyte adhesion requires PI3Kgamma activation and involves Src kinases, the guanine nucleotide exchange factor Vav-1, and the small GTPase Rac1.
Positive_regulation (activation) of PI3Kgamma in monocyte associated with adhesions
4) Confidence 0.67 Published 2006 Journal J. Immunol. Section Abstract Doc Link 16424197 Disease Relevance 0.61 Pain Relevance 0.49
In addition, morphine-induced apoptosis seems to be dependent on the activation of phosphatidylinositol 3-kinase (PI3K), as PI3K inhibition by the PI3K inhibitor LY294002 significantly enhanced morphine-induced apoptosis.
Positive_regulation (activation) of PI3K associated with apoptosis and morphine
5) Confidence 0.64 Published 2006 Journal J. Neuroimmunol. Section Abstract Doc Link 16529824 Disease Relevance 1.10 Pain Relevance 0.93
In addition, morphine-induced apoptosis seems to be dependent on the activation of phosphatidylinositol 3-kinase (PI3K), as PI3K inhibition by the PI3K inhibitor LY294002 significantly enhanced morphine-induced apoptosis.
Positive_regulation (activation) of phosphatidylinositol 3-kinase associated with apoptosis and morphine
6) Confidence 0.64 Published 2006 Journal J. Neuroimmunol. Section Abstract Doc Link 16529824 Disease Relevance 1.10 Pain Relevance 0.93
The mechanisms involve activation of the PI3K/Akt signaling pathway.


Positive_regulation (activation) of PI3K
7) Confidence 0.49 Published 2010 Journal Neurotoxicology Section Body Doc Link 19879292 Disease Relevance 0.05 Pain Relevance 0
Our results suggest that Brenner tumors and TCCs follow different tumorigenic pathways, whereas borderline and malignant Brenner tumors are low-grade neoplasms with activation of the PI3K/AKT pathway through EGFR, TCCs are high-grade tumors that have p53 mutations and p16 and p53 protein overexpression.
Positive_regulation (activation) of PI3K associated with malignant neoplastic disease, cancer and transitional cell carcinoma
8) Confidence 0.45 Published 2009 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 19033864 Disease Relevance 2.02 Pain Relevance 0.03
In fact, we have shown that NSAIDs, in some instances, increase Akt phosphorylation in human pancreatic carcinoma cells suggesting activation of the phosphatidylinositol 3'-kinase (PI3K)-Akt survival (antiapoptotic) pathway.
Positive_regulation (activation) of PI3K associated with pancreatic cancer and cinod
9) Confidence 0.44 Published 2003 Journal J. Gastrointest. Surg. Section Abstract Doc Link 12654560 Disease Relevance 0.54 Pain Relevance 0.44
Taken together, this would suggest that half of breast cancers have an upregulated PI3K/Akt pathway due to a constitutively active signal downstream of membrane receptors.
Positive_regulation (upregulated) of PI3K associated with breast cancer
10) Confidence 0.31 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2242654 Disease Relevance 0.58 Pain Relevance 0
In MM cells with increased PI3K activity, Rosiglitazone acted cooperatively with Onconase to inhibit cell proliferation [11].
Positive_regulation (increased) of PI3K associated with lung cancer
11) Confidence 0.29 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2829496 Disease Relevance 1.18 Pain Relevance 0
Calcitriol induces a number of non-genomic responses including rapid intestinal absorption of calcium, release of calcium from intracellular stores, opening of voltage-gated calcium and chloride channels, and the activation of protein kinase C, protein kinase A, phosphatidylinositol-3 kinase (PI3K) and phospholipase C 4.


Positive_regulation (activation) of PI3K associated with kinase c
12) Confidence 0.26 Published 2010 Journal Journal of Cancer Section Body Doc Link PMC2938072 Disease Relevance 0.65 Pain Relevance 0.05
These PI 3-K/Akt inhibition studies demonstrate that PI 3-K and Akt are required for NF-?
Positive_regulation (required) of PI 3-K
13) Confidence 0.20 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 0.16 Pain Relevance 0
Various PI 3-kinase inhibitors such as Wortmannin, LY294002 and dominant-negative Akt expression vector were used to fully prove the involvement of PI 3-K/Akt pathway in the regulation of NF-?
Positive_regulation (pathway) of PI 3-K
14) Confidence 0.20 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 0.21 Pain Relevance 0
Recently, interactions between the PI3K/AKT and p53 signaling pathways have been described in which activation of the PI3K/AKT pathway through PTEN or PIK3CA mutations, together with p53 inactivation, results in malignant transformation [15].
Positive_regulation (activation) of PI3K associated with malignant neoplastic disease
15) Confidence 0.18 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 0.60 Pain Relevance 0
In contrast to p53 and other tumor-suppressor pathways, the PI3K pathway is activated in cancer, making this an optimal target for therapy.
Positive_regulation (activated) of PI3K associated with cancer
16) Confidence 0.16 Published 2010 Journal Breast Cancer Res Section Body Doc Link PMC2972555 Disease Relevance 1.11 Pain Relevance 0.03
Our results indicate that PI3-K is required for IL-1?
Positive_regulation (required) of PI3-K
17) Confidence 0.14 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0.23 Pain Relevance 0.52
This implicates the activation of PI3K, map kinase (ERK1/2) and p70S6 kinase in the collagen-mediated effect on PC3 cells.


Positive_regulation (activation) of PI3K
18) Confidence 0.13 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC320496 Disease Relevance 0.67 Pain Relevance 0.06
Upregulated PI3K then drove Akt dependent activation of TOR which led to enhanced liberation of eIF4E from 4E-BP1.
Positive_regulation (Upregulated) of PI3K
19) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.10 Pain Relevance 0
In addition, it accelerates cholesteryl ester accumulation in human monocyte-derived macrophages by increasing ACAT-1 expression via JAK2 and PI3K, thereby suppressing cholesterol efflux [29].
Positive_regulation (increasing) of PI3K in macrophages
20) Confidence 0.10 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2846344 Disease Relevance 0.14 Pain Relevance 0.14

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