INT108203

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Context Info
Confidence 0.54
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 28
Total Number 30
Disease Relevance 16.38
Pain Relevance 3.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (AKT1) nucleoplasm (AKT1) transport (AKT1)
small molecule metabolic process (AKT1) enzyme binding (AKT1) carbohydrate metabolic process (AKT1)
Anatomy Link Frequency
HeLa 4
muscle 2
lens capsule 2
RL95-2 2
HT-1080 2
AKT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
local anesthetic 10 99.88 Very High Very High Very High
Opioid 3 99.80 Very High Very High Very High
aspirin 11 99.78 Very High Very High Very High
cva 2 99.76 Very High Very High Very High
Morphine 10 98.80 Very High Very High Very High
agonist 21 98.10 Very High Very High Very High
Inflammation 9 91.84 High High
dexamethasone 8 89.60 High High
opioid receptor 4 89.56 High High
sodium channel 2 89.44 High High
Disease Link Frequency Relevance Heat
Apoptosis 807 100.00 Very High Very High Very High
Targeted Disruption 18 100.00 Very High Very High Very High
Cervical Cancer 49 99.80 Very High Very High Very High
Hemorrhage 2 99.76 Very High Very High Very High
Thrombosis 2 99.16 Very High Very High Very High
Capsule Opacification 135 98.76 Very High Very High Very High
Adhesions 24 98.60 Very High Very High Very High
Cancer 584 98.16 Very High Very High Very High
Death 271 97.80 Very High Very High Very High
Fibrosarcoma 16 95.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our study demonstrated that HDAC inhibitors, such as valproic acid and butyrate, induce apoptosis in HeLa cervical cancer cells by inhibition of gene expression of Akt1 and Akt2.
Negative_regulation (inhibition) of Gene_expression (expression) of Akt1 in HeLa associated with cervical cancer and apoptosis
1) Confidence 0.54 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 1.15 Pain Relevance 0
Valproic acid treatment also reduced the levels of the Akt1 and Akt2 mRNA, but to a lesser degree (Fig. 1B).
Negative_regulation (reduced) of Gene_expression (levels) of Akt1
2) Confidence 0.54 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.33 Pain Relevance 0
Treatment of HeLa cells with HDAC inhibitors such as valproic acid and butyrate leads to inhibition of Akt1 and Akt2 expression, consequently to deactivation of cellular Akt (Fig. 1 and 2).
Negative_regulation (inhibition) of Gene_expression (expression) of Akt1 in HeLa
3) Confidence 0.54 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.86 Pain Relevance 0
Expression of dominant negative mutants of Rac and Cdc42 blocked the opioid-induced JNK activation, and a partial inhibition was observed in the presence of the dominant negative mutant of Ras.
Negative_regulation (blocked) of Gene_expression (Expression) of Rac associated with opioid
4) Confidence 0.41 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12558970 Disease Relevance 0.24 Pain Relevance 0.51
Here we report that the induction of cancer cell apoptosis by HDAC inhibitors, such as valproic acid and butyrate, is achieved through inhibition of gene expression of Akt1 and Akt2, pro-survival factors involved in many cell signalling pathways.
Negative_regulation (inhibition) of Gene_expression (expression) of Akt1 associated with cancer and apoptosis
5) Confidence 0.40 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 1.11 Pain Relevance 0
The negative effect of valproic acid or butyrate on Akt expression could be mediated through a direct or indirect mechanism, i.e. through inhibiting deacetylation of nonhistone proteins, such as transcription regulators, or gene activation of some negative regulators of Akt gene transcription.
Negative_regulation (effect) of Gene_expression (expression) of Akt
6) Confidence 0.39 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.51 Pain Relevance 0
In addition, introduction of constitutively active Akt blocks caspase-3 activation and rescues cells from apoptotic death upon butyrate treatment (Fig. 4).
Negative_regulation (blocks) of Gene_expression (introduction) of Akt associated with apoptosis and death
7) Confidence 0.39 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.97 Pain Relevance 0
We, for the first time, show that the down-regulation of Akt activity is a consequence of inhibition of Akt1 and Akt2 expression by valproic acid and butyrate.
Negative_regulation (inhibition) of Gene_expression (expression) of Akt1
8) Confidence 0.39 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.66 Pain Relevance 0
As shown in Fig. 5C, both valproic acid and butyrate decreased the levels of Akt1 and Akt2 mRNA to a certain degree, but not significantly.
Negative_regulation (decreased) of Gene_expression (levels) of Akt1
9) Confidence 0.39 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.25 Pain Relevance 0
Decreasing AKT1 levels with pshAkt1 likewise reduced NF?
Negative_regulation (reduced) of Gene_expression (levels) of AKT1
10) Confidence 0.35 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.26 Pain Relevance 0
Decreasing AKT1 levels with pshAkt1 likewise reduced NF?
Negative_regulation (Decreasing) of Gene_expression (levels) of AKT1
11) Confidence 0.35 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.26 Pain Relevance 0
Western blotting analysis demonstrated that the levels of Akt protein and phosphorylated Akt were diminished by the treatment in the control cells, but not in the cells expressing the constitutively active Akt (Fig. 4B).
Negative_regulation (diminished) of Gene_expression (levels) of Akt
12) Confidence 0.34 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.85 Pain Relevance 0
Moreover, inhibition of Akt or nuclear factor-kappaB (NF-kappaB) expression by RNA interference technology also dramatically increased morphine-induced apoptosis.
Negative_regulation (inhibition) of Gene_expression (expression) of Akt associated with apoptosis and morphine
13) Confidence 0.33 Published 2006 Journal J. Neuroimmunol. Section Abstract Doc Link 16529824 Disease Relevance 1.07 Pain Relevance 0.92
As demonstrated previously, transfection of RL95-2 cells with the DN-Akt decreased Akt phosphorylation and caused a reduction of COX-2 expression [42].
Negative_regulation (decreased) of Gene_expression (transfection) of DN-Akt in RL95-2
14) Confidence 0.32 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 0.34 Pain Relevance 0
Decreasing AKT1 levels with pshAkt1 likewise reduced NF?
Negative_regulation (Decreasing) of Gene_expression (levels) of pshAkt1
15) Confidence 0.30 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.26 Pain Relevance 0
Decreasing AKT1 levels with pshAkt1 likewise reduced NF?
Negative_regulation (reduced) of Gene_expression (levels) of pshAkt1
16) Confidence 0.30 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.26 Pain Relevance 0
These studies identified that aspirin induces a decrease in expression of AKT1, which is regulated by the ?
Negative_regulation (decrease) of Gene_expression (expression) of AKT1 associated with aspirin
17) Confidence 0.27 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0.47 Pain Relevance 0.38
Local anesthetics also inhibited the activities of anti-apoptotic kinases protein kinase B (Akt) and extracellular signal regulated mitrogen-activated protein kinase.
Negative_regulation (inhibited) of Gene_expression (activities) of Akt associated with apoptosis and local anesthetic
18) Confidence 0.26 Published 2003 Journal Am. J. Nephrol. Section Abstract Doc Link 12586958 Disease Relevance 1.22 Pain Relevance 1.07
Treatment with AR-12 for both 8 and 24 h following UV irradiation significantly (p<0.01) decreased pAkt expression.
Negative_regulation (decreased) of Gene_expression (expression) of pAkt
19) Confidence 0.25 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2994344 Disease Relevance 0.54 Pain Relevance 0
In the presence of AR-12, all doses tested were capable of significantly (p<0.01) decreasing pAkt expression in irradiated LEC compared to LEC that received UV irradiation in the absence of AR-12 (Figure 2A,B).
Negative_regulation (decreasing) of Gene_expression (expression) of pAkt
20) Confidence 0.25 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0.23 Pain Relevance 0

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