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Context Info
Confidence 0.12
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 4.16
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PIK3CG) plasma membrane (PIK3CG) cytoplasm (PIK3CG)
PIK3CG (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 4 97.32 Very High Very High Very High
Opioid 3 95.00 High High
opioid receptor 4 90.56 High High
Potency 2 75.00 Quite High
agonist 5 67.24 Quite High
Delta opioid receptors 1 66.64 Quite High
Pain 1 61.04 Quite High
Inflammation 48 27.00 Quite Low
cytokine 26 23.72 Low Low
Inflammatory mediators 7 20.40 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 136 99.52 Very High Very High Very High
Obesity 53 98.24 Very High Very High Very High
Malignant Neoplastic Disease 40 98.04 Very High Very High Very High
Cancer 227 96.56 Very High Very High Very High
Carcinoma 122 94.88 High High
Pituitary Cancer 39 92.84 High High
Endometrial Stromal Sarcoma 78 92.12 High High
Endometrial Cancer 346 87.20 High High
Adenocarcinoma 12 85.76 High High
Endometroid Carcinoma 42 82.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The anti-EGFR agents result in down regulation of the MAPK and PI3K/AKT signaling pathways.
Regulation (regulation) of PI3K
1) Confidence 0.12 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 0.76 Pain Relevance 0.05
Previous study has shown that miR-126 is located in the chromosome region of 9q34.3 and regulates phosphatidylinositol 3-kinase (PI3K) signaling by targeting the PI3K regulatory subunit beta (p85b).
Regulation (targeting) of PI3K
2) Confidence 0.11 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3017030 Disease Relevance 0.62 Pain Relevance 0
However, PI 3-K inhibitors had no effect in non mutated PTEN HEC 1-A cells suggesting that PI 3-K activity is important in the control and inhibition of apoptosis.

Regulation (important) of PI 3-K associated with apoptosis
3) Confidence 0.11 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 0.72 Pain Relevance 0
Insulin acted at the insulin receptor via pathways dependent on tyrosine kinase and phosphatidylinositol 3 kinase because the insulin effect was eliminated by the insulin receptor antagonist, hydroxy-2-naphthalenylmethylphosphonic acid trisacetoxymethyl ester, the tyrosine kinase inhibitor lavendustin A, and the phosphatidylinositol 3 kinase antagonist wortmannin.
Regulation (dependent) of phosphatidylinositol 3 kinase associated with antagonist
4) Confidence 0.10 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17308032 Disease Relevance 0.06 Pain Relevance 0.23
These results demonstrate that the ability of PTEN to negatively regulate the PI 3-K/Akt/NF-?
Regulation (regulate) of PI 3-K
5) Confidence 0.08 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 0.23 Pain Relevance 0
Moreover, patients with dysregulation of PI3K/AKT signaling pathway and p53 alterations had shorter survival than patients with only p53 alterations [15].
Regulation (dysregulation) of PI3K
6) Confidence 0.03 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 0.70 Pain Relevance 0
This molecule acts as a dual protein and lipid phosphatase that can modulate cell survival, proliferation and apoptosis through its downstream effects on phosphatidylinositol 3-kinase (PI3K) and the AKT1 gene [72],[82],[83].
Regulation (effects) of PI3K associated with apoptosis
7) Confidence 0.02 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2771360 Disease Relevance 0.54 Pain Relevance 0
In addition, the receptor-mediated JNK activation was dependent on Src family tyrosine kinases, but independent of phosphatidylinositol-3 kinase and EGF receptor tyrosine kinases.
Neg (independent) Regulation (independent) of phosphatidylinositol-3 kinase
8) Confidence 0.00 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12558970 Disease Relevance 0.20 Pain Relevance 0.48
target genes (UCP-2, LPL, p85aPI3K, and PPAR?
Regulation (target) of p85aPI3K
9) Confidence 0.00 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0.32 Pain Relevance 0

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