INT10821

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Context Info
Confidence 0.67
First Reported 1980
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 32
Total Number 32
Disease Relevance 9.43
Pain Relevance 7.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Abo) Golgi apparatus (Abo) carbohydrate metabolic process (Abo)
Anatomy Link Frequency
liver 4
plasma 2
kidney 2
testes 1
Terminalia 1
Abo (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 7 100.00 Very High Very High Very High
Paracetamol 63 99.98 Very High Very High Very High
Pain 5 99.44 Very High Very High Very High
Morphine 15 97.72 Very High Very High Very High
alcohol 6 97.48 Very High Very High Very High
Hippocampus 6 94.24 High High
Angina 1 94.00 High High
Inflammation 52 93.36 High High
Analgesic 4 90.32 High High
Intracerebroventricular 1 89.24 High High
Disease Link Frequency Relevance Heat
Apoptosis 13 100.00 Very High Very High Very High
Exanthema 5 99.68 Very High Very High Very High
Stress 20 99.60 Very High Very High Very High
Ataxia 1 99.46 Very High Very High Very High
Pain 3 99.44 Very High Very High Very High
Fatigue 7 99.30 Very High Very High Very High
Depressive Disorder 2 99.12 Very High Very High Very High
Jaundice 1 98.84 Very High Very High Very High
Hepatotoxicity 22 98.82 Very High Very High Very High
Aberrant Crypt Foci 5 98.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This sex difference in the glucuronidation of the GT 1 substrates was abolished by detergent activation of the transferase enzyme in vitro.
Positive_regulation (activation) of transferase
1) Confidence 0.67 Published 1984 Journal Biochem. Pharmacol. Section Abstract Doc Link 6439213 Disease Relevance 0.25 Pain Relevance 0.09
Daily treatment of male rats with high doses of Paracetamol (500 mg/kg) during spermatogenesis provokes a significant decrease of testes weight (p is less than 0.001), a significant increase of testicular cytosol glutathione transferase activity ( p is less than 0.02) and of lipid peroxides in the whole homogenate (p is less than 0.01) but not in the microsomes.
Positive_regulation (increase) of transferase in testes associated with paracetamol
2) Confidence 0.61 Published 1984 Journal Arch. Toxicol. Suppl. Section Abstract Doc Link 6595979 Disease Relevance 0 Pain Relevance 0.17
During pregnancy the glucuronyl transferase activity increased significantly in the liver while no change was observed in the intestinal microsomal fraction.
Positive_regulation (increased) of transferase in liver
3) Confidence 0.51 Published 1981 Journal Dev Pharmacol Ther Section Abstract Doc Link 6802622 Disease Relevance 0 Pain Relevance 0.16
During development the hepatic glucuronyl transferase activity increased 16-fold from day 1 after birth until a maximum of 9.97 nmol/min/mg on day 20.
Positive_regulation (increased) of transferase
4) Confidence 0.51 Published 1981 Journal Dev Pharmacol Ther Section Abstract Doc Link 6802622 Disease Relevance 0 Pain Relevance 0.17
The use of tenoxicam has recently increased and it is reported in the literature that treatments lasting between a few weeks to three months caused increases in serum alanine transferase (ALT), aspartate transferase (AST), gamma glutamyl transferase (GGT) and bilirubin in humans.
Positive_regulation (increases) of transferase
5) Confidence 0.48 Published 1999 Journal Drug Metabol Drug Interact Section Abstract Doc Link 10707126 Disease Relevance 0.09 Pain Relevance 0.14
Plasma alanine transferase activity was elevated more and earlier after treatment with acetaminophen and allyl alcohol compared to administration of acetaminophen alone.
Positive_regulation (elevated) of alanine transferase in Plasma associated with paracetamol and alcohol
6) Confidence 0.45 Published 1985 Journal Biochem. Pharmacol. Section Abstract Doc Link 3977950 Disease Relevance 0.07 Pain Relevance 0.70
This diabetes-induced defect in the glucuronidation of GT 1 substrates was abolished by insulin treatment of the animals and was diminished or completely abolished by detergent activation of the transferase enzyme in vitro.
Positive_regulation (activation) of transferase associated with diabetes mellitus
7) Confidence 0.45 Published 1984 Journal Biochem. Pharmacol. Section Abstract Doc Link 6439213 Disease Relevance 0.24 Pain Relevance 0.09
Increased membrane constraint is proposed as the mechanism responsible for the transferase defect. 3-Methylcholanthrene induction abolished the streptozotocin-induced defect in 4-nitrophenol glucuronidation, whereas phenobarbitone did not.
Positive_regulation (induction) of transferase
8) Confidence 0.45 Published 1984 Journal Biochem. Pharmacol. Section Abstract Doc Link 6439213 Disease Relevance 0.23 Pain Relevance 0.09
The use of tenoxicam has recently increased and it is reported in the literature that treatments lasting between a few weeks to three months caused increases in serum alanine transferase (ALT), aspartate transferase (AST), gamma glutamyl transferase (GGT) and bilirubin in humans.
Positive_regulation (increases) of transferase
9) Confidence 0.35 Published 1999 Journal Drug Metabol Drug Interact Section Abstract Doc Link 10707126 Disease Relevance 0.09 Pain Relevance 0.14
The use of tenoxicam has recently increased and it is reported in the literature that treatments lasting between a few weeks to three months caused increases in serum alanine transferase (ALT), aspartate transferase (AST), gamma glutamyl transferase (GGT) and bilirubin in humans.
Positive_regulation (increases) of transferase
10) Confidence 0.35 Published 1999 Journal Drug Metabol Drug Interact Section Abstract Doc Link 10707126 Disease Relevance 0.09 Pain Relevance 0.14
Influence of oxypangam upon the induction of tyrosine aminotransferase, the NAD content and the ADPR transferase activity in several organs of the rat.
Positive_regulation (induction) of ADPR transferase
11) Confidence 0.29 Published 1987 Journal Gen. Pharmacol. Section Title Doc Link 2881834 Disease Relevance 0.19 Pain Relevance 0.09
Thus, the induction of these UDP-glucuronosyl transferase activities by BSO is preserved in senescent animals.
Positive_regulation (induction) of transferase
12) Confidence 0.23 Published 1992 Journal Exp. Gerontol. Section Abstract Doc Link 1521595 Disease Relevance 0.08 Pain Relevance 0.41
BSO treatment increased the partial clearance to acetaminophen glucuronide by 90% and 41% in young and old rats, respectively, and similarly, induced p-nitrophenol and 1-naphthol UDP-glucuronosyl transferase activities to a greater extent in young versus senescent animals.
Positive_regulation (induced) of transferase associated with paracetamol
13) Confidence 0.23 Published 1992 Journal Exp. Gerontol. Section Abstract Doc Link 1521595 Disease Relevance 0.07 Pain Relevance 0.42
The probe for in situ hybridization was labeled at its 3' end using terminal deoxynucleotidyl transferase and [35S]dATP.
Positive_regulation (using) of deoxynucleotidyl transferase
14) Confidence 0.22 Published 2000 Journal Brain Res. Bull. Section Abstract Doc Link 10822164 Disease Relevance 0.15 Pain Relevance 0.95
Significant increases in UDP-glucuronosyltransferase and glutathione S-transferase activities were also observed following 3 days of exposure to BSO in the drinking water at a concentration as low as 5 mM.
Positive_regulation (increases) of transferase
15) Confidence 0.20 Published 1990 Journal Toxicology Section Abstract Doc Link 2125759 Disease Relevance 0.08 Pain Relevance 0.15
Induction of rat UDP-glucuronosyltransferase and glutathione S-transferase activities by L-buthionine-S,R-sulfoximine without induction of cytochrome P-450.
Positive_regulation (Induction) of transferase
16) Confidence 0.20 Published 1990 Journal Toxicology Section Title Doc Link 2125759 Disease Relevance 0.06 Pain Relevance 0.14
Intraperitoneal, intragastric and all BSO-drinking water exposures also significantly induced (130-195%) cytosolic glutathione S-transferase activity toward 1-chloro-2,4-dinitrobenzene.
Positive_regulation (induced) of transferase
17) Confidence 0.20 Published 1990 Journal Toxicology Section Abstract Doc Link 2125759 Disease Relevance 0.09 Pain Relevance 0.15
The increase in the transferase activity was not recovered by the treatment with dithiothreitol.
Positive_regulation (increase) of transferase
18) Confidence 0.17 Published 1996 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 8912918 Disease Relevance 0.09 Pain Relevance 0.53
Acetaminophen-derived activation of liver microsomal glutathione S-transferase of rats.
Positive_regulation (activation) of transferase in liver associated with paracetamol
19) Confidence 0.15 Published 1996 Journal Jpn. J. Pharmacol. Section Title Doc Link 8912918 Disease Relevance 0.09 Pain Relevance 0.55
Exposure to sulindac significantly increased the apoptotic index (terminal deoxynucleotide transferase dUTP nick-end labeling (TUNEL)-positive cells) in BCAC.
Positive_regulation (increased) of deoxynucleotide transferase associated with apoptosis
20) Confidence 0.14 Published 2002 Journal Jpn. J. Cancer Res. Section Abstract Doc Link 11927004 Disease Relevance 0.98 Pain Relevance 0.08

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