INT10824

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Context Info
Confidence 0.57
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 38
Total Number 38
Disease Relevance 25.18
Pain Relevance 3.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cyp19a1) endoplasmic reticulum (Cyp19a1) cytoplasm (Cyp19a1)
Anatomy Link Frequency
thymus 3
plasma 1
spinal cord 1
uterine 1
granulosa cells 1
Cyp19a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Eae 7 99.16 Very High Very High Very High
corticosteroid 7 97.38 Very High Very High Very High
Spinal cord 10 97.08 Very High Very High Very High
Pain 71 96.96 Very High Very High Very High
Dismenorea 24 96.28 Very High Very High Very High
agonist 30 95.24 Very High Very High Very High
cINOD 13 94.88 High High
antagonist 44 94.40 High High
depression 16 93.88 High High
Morphine 5 92.08 High High
Disease Link Frequency Relevance Heat
Coronary Artery Disease 48 99.88 Very High Very High Very High
Cognitive Disorder 36 99.84 Very High Very High Very High
Prostate Cancer 7 99.84 Very High Very High Very High
Cardiovascular Disease 151 99.80 Very High Very High Very High
Bone Cancer 24 99.80 Very High Very High Very High
Aging 27 99.76 Very High Very High Very High
Apoptosis 59 99.68 Very High Very High Very High
Urinary Tract Infection 36 99.64 Very High Very High Very High
Injury 8 99.16 Very High Very High Very High
Breast Cancer 137 99.02 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some pesticides, such as fenarimol, prochloraz, and other imidazole fungicides possess the ability to inhibit estrogen biosynthesis through CYP19 aromatase inhibition in vitro [26-28], preventing the conversion of androgens to estrogens.
Negative_regulation (inhibition) of CYP19
1) Confidence 0.57 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1524969 Disease Relevance 0 Pain Relevance 0.05
Pharmacological inhibition of aromatase caused apoptosis of CCI rat DRG neurons.
Negative_regulation (inhibition) of aromatase in DRG associated with eae and apoptosis
2) Confidence 0.53 Published 2010 Journal Glia Section Abstract Doc Link 19565659 Disease Relevance 1.29 Pain Relevance 0.69
Exemestane has no detectable effect on adrenal biosynthesis of corticosteroids, aldosterone, or on other enzymes involved in the steroidogenic pathway up to a concentration at least 600 times higher than that inhibiting the aromatase enzyme (Dixon 2004).
Negative_regulation (inhibiting) of aromatase enzyme associated with corticosteroid
3) Confidence 0.49 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643110 Disease Relevance 0.08 Pain Relevance 0.05
The agent is metabolized by CYP3A4 to compounds that are inactive or show minimal inhibition of aromatase (Wong and Pritchard 2005).
Negative_regulation (inhibition) of aromatase
4) Confidence 0.49 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643110 Disease Relevance 0.27 Pain Relevance 0.04
The role of inhibition of aromatase in prostate cancer therapy, which was postulated for aminoglutethimide, could not be confirmed by the use of more selective aromatase inhibitors, such as formestane.
Negative_regulation (inhibition) of aromatase associated with prostate cancer
5) Confidence 0.45 Published 1996 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 8603034 Disease Relevance 0.91 Pain Relevance 0
An attempt has been made to regenerate the thymus in intact aging rats using inhibitors of the aromatase system, in the hope that this maneuver could lead to the use of such chemical intervention in the treatment of immunodeficiency syndromes.
Negative_regulation (inhibitors) of aromatase in thymus associated with aging, syndrome and immunodeficiency
6) Confidence 0.43 Published 1992 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 1521922 Disease Relevance 0.54 Pain Relevance 0.08
In aging rats, both aromatase inhibitors restored the thymus, which appeared normal histologically.
Negative_regulation (inhibitors) of aromatase in thymus associated with aging
7) Confidence 0.43 Published 1992 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 1521922 Disease Relevance 0.58 Pain Relevance 0.07
Aromatase inhibitors regenerate the thymus in aging male rats.
Negative_regulation (inhibitors) of Aromatase in thymus associated with aging
8) Confidence 0.43 Published 1992 Journal Int. J. Immunopharmacol. Section Title Doc Link 1521922 Disease Relevance 0.52 Pain Relevance 0.08
To evaluate the presence of testosterone and its metabolism in rat C6 glioma cells, we cultured them in media with or without the addition of testosterone propionate and anastrozole, a blocker of aromatase, the enzyme needed to transform testosterone into estradiol.
Negative_regulation (blocker) of aromatase associated with glioma
9) Confidence 0.43 Published 2009 Journal J. Cell. Physiol. Section Abstract Doc Link 19492405 Disease Relevance 0.26 Pain Relevance 0.17
Aromatase inhibitors versus placebo
Negative_regulation (inhibitors) of Aromatase
10) Confidence 0.43 Published 2007 Journal Breast Cancer Res Treat Section Body Doc Link PMC2001222 Disease Relevance 0.64 Pain Relevance 0
Comparative studies of aromatase inhibitors
Negative_regulation (inhibitors) of aromatase
11) Confidence 0.43 Published 2007 Journal Breast Cancer Res Treat Section Body Doc Link PMC2001222 Disease Relevance 0.70 Pain Relevance 0
Aromatase inhibitors and cardiovascular disease
Negative_regulation (inhibitors) of Aromatase associated with cardiovascular disease
12) Confidence 0.43 Published 2007 Journal Breast Cancer Res Treat Section Body Doc Link PMC2001222 Disease Relevance 1.33 Pain Relevance 0
A prospective open label randomized multicenter substudy was performed in the German TEAM Trial Group to test the hypothesis that the irreversible inactivation of aromatase by exemestane (EXE; N = 78) would result in less endometrial proliferation than tamoxifen (TAM; N = 65) (Kieback et al 2006).
Negative_regulation (inactivation) of aromatase associated with endometriosis (extended)
13) Confidence 0.36 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643110 Disease Relevance 0.67 Pain Relevance 0
The effects of a profound long-term estrogen deprivation achievable with the third-generation aromatase inhibitors in respect to the bone health has been a major concern.
Negative_regulation (deprivation) of aromatase
14) Confidence 0.36 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643110 Disease Relevance 0.45 Pain Relevance 0
When accrual to the B-33 trial was initiated, no other information existed on benefit from aromatase inhibitors in this setting.
Negative_regulation (inhibitors) of aromatase
15) Confidence 0.36 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643110 Disease Relevance 0.35 Pain Relevance 0
Exemestane appears to be different from other aromatase inhibitors with its less detrimental effect on bone after 12 months of treatment.
Negative_regulation (inhibitors) of aromatase
16) Confidence 0.36 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643110 Disease Relevance 0.40 Pain Relevance 0
These compounds work by blocking the aromatase enzyme in the final step of estrogen synthesis, thus lowering circulating estrogen levels.
Negative_regulation (blocking) of aromatase enzyme
17) Confidence 0.36 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643110 Disease Relevance 0.59 Pain Relevance 0.06
Both in vitro data [11,12] and in vivo data [13] show that COX-2 inhibition is associated with prostaglandin E2 reduction and suppression of aromatase activity.
Negative_regulation (suppression) of aromatase
18) Confidence 0.35 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2374974 Disease Relevance 1.15 Pain Relevance 0.23
Another study conducted in healthy, estrogen-treated postmenopausal women treated with testosterone did not reveal any effects of aromatase inhibition on cognition [126].
Negative_regulation (inhibition) of aromatase associated with cognitive disorder
19) Confidence 0.31 Published 2007 Journal Breast Cancer Res Treat Section Body Doc Link PMC2001222 Disease Relevance 0.96 Pain Relevance 0
Safety of aromatase inhibitors in the adjuvant setting

The third-generation aromatase inhibitors (AIs) letrozole, anastrozole, and exemestane are replacing tamoxifen as adjuvant therapy in most postmenopausal women with early breast cancer.

Negative_regulation (inhibitors) of aromatase associated with reprotox - general 1
20) Confidence 0.31 Published 2007 Journal Breast Cancer Res Treat Section Title Doc Link PMC2001222 Disease Relevance 0.48 Pain Relevance 0.07

General Comments

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