INT108241

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Context Info
Confidence 0.27
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.78
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2ry4) plasma membrane (P2ry4) signal transducer activity (P2ry4)
Anatomy Link Frequency
blood 2
neuron 1
P2ry4 (Mus musculus)
Pain Link Frequency Relevance Heat
tetrodotoxin 2 99.84 Very High Very High Very High
Pain 16 91.08 High High
antagonist 39 88.24 High High
agonist 24 84.12 Quite High
Migraine 17 83.88 Quite High
IPN 1 82.92 Quite High
adenocard 29 81.68 Quite High
Neurotransmitter 2 75.00 Quite High
Lasting pain 1 56.24 Quite High
cytokine 10 55.28 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 30 100.00 Very High Very High Very High
Stress 32 98.24 Very High Very High Very High
Pain 17 91.08 High High
Headache 15 83.88 Quite High
Cv Unclassified Under Development 18 83.20 Quite High
Inflammatory Pain 1 82.92 Quite High
Neuropathic Pain 1 82.04 Quite High
Neointima 10 65.40 Quite High
Increased Venous Pressure Under Development 122 62.08 Quite High
Hypoxia 12 50.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PACAP-(1-27) caused membrane hyperpolarization antagonised by PACAP-(6-38), apamin and P2Y receptor desensitisation, reduced by tetrodotoxin, but not affected by L-NAME and by P2X receptor desensitisation.
Neg (not) Negative_regulation (reduced) of P2Y receptor associated with tetrodotoxin
1) Confidence 0.27 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12559380 Disease Relevance 0 Pain Relevance 0.47
We also provide new original data showing a time-dependent downregulation of P2Y2 and P2Y4 receptor expression and function in purified SGCs cultures from TG, in comparison with primary mixed neuron-SGCs cultures.
Negative_regulation (downregulation) of P2Y4 receptor in neuron
2) Confidence 0.11 Published 2010 Journal Neuron Glia Biol. Section Abstract Doc Link 20604978 Disease Relevance 0.56 Pain Relevance 0.56
Vessel dilation induced by acute increases in blood flow is markedly suppressed in P2X4 receptor knockout mice [57].
Negative_regulation (suppressed) of P2X4 receptor in blood associated with targeted disruption
3) Confidence 0.05 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 0.68 Pain Relevance 0.04
P2X4 receptor knockout mice are incapable of adaptive vascular remodelling, that is, a decrease in vessel size in response to a chronic decrease in blood flow [57].


Negative_regulation (decrease) of P2X4 receptor in blood associated with targeted disruption
4) Confidence 0.04 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 0.55 Pain Relevance 0.03

General Comments

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