INT108242

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Context Info
Confidence 0.32
First Reported 2003
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.81
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2ry4) plasma membrane (P2ry4) signal transducer activity (P2ry4)
Anatomy Link Frequency
neurons 1
central nervous system 1
P2ry4 (Mus musculus)
Pain Link Frequency Relevance Heat
tetrodotoxin 3 100.00 Very High Very High Very High
antagonist 15 99.88 Very High Very High Very High
Inflammation 40 97.80 Very High Very High Very High
cytokine 16 95.04 Very High Very High Very High
Central nervous system 1 94.84 High High
agonist 4 84.12 Quite High
adenocard 5 80.48 Quite High
Neurotransmitter 12 75.00 Quite High
GABAergic 3 52.80 Quite High
Neuropeptide 1 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 35 97.80 Very High Very High Very High
Pressure And Volume Under Development 6 94.52 High High
Pneumonia 13 75.84 Quite High
Lung Injury 29 70.24 Quite High
Injury 2 47.24 Quite Low
Adult Respiratory Distress Syndrome 10 5.00 Very Low Very Low Very Low
Pulmonary Edema 5 5.00 Very Low Very Low Very Low
Depression 3 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PPADS is a purinergic receptor antagonist that acts on P2Y2 and P2Y4 [15], while extracellular ATP has been observed to induce chemotaxis of microglia, which acts as an innate immune system in the central nervous system, mediated by the P2X4 and P2Y12 receptors [30].
Regulation (acts) of P2Y4 in central nervous system associated with antagonist and central nervous system
1) Confidence 0.32 Published 2008 Journal Respir Res Section Body Doc Link PMC2627837 Disease Relevance 0.81 Pain Relevance 0.39
PACAP-(1-27) caused membrane hyperpolarization antagonised by PACAP-(6-38), apamin and P2Y receptor desensitisation, reduced by tetrodotoxin, but not affected by L-NAME and by P2X receptor desensitisation.
Neg (not) Regulation (affected) of P2Y receptor associated with tetrodotoxin
2) Confidence 0.17 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12559380 Disease Relevance 0 Pain Relevance 0.47
The lack of P2Y2 and P2Y4 immunoreactivity in neurons was confirmed by quantification of fluorescence images using the criterion that the average intensity of a positively stained cell should be greater than average intensity +3 SD of cells that were incubated with secondary antibody alone, as described in the Materials and methods.
Regulation (immunoreactivity) of P2Y4 in neurons
3) Confidence 0.11 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2518726 Disease Relevance 0 Pain Relevance 0.03

General Comments

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