INT108249

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Context Info
Confidence 0.32
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 1.85
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prdx2) mitochondrion (Prdx2) oxidoreductase activity (Prdx2)
cytoplasm (Prdx2)
Anatomy Link Frequency
eyes 2
macrophages 1
Prdx2 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 10 100.00 Very High Very High Very High
Inflammation 100 96.12 Very High Very High Very High
anesthesia 10 50.64 Quite High
alcohol 12 50.00 Quite Low
fibrosis 28 20.48 Low Low
cytokine 20 5.00 Very Low Very Low Very Low
ketamine 7 5.00 Very Low Very Low Very Low
tolerance 6 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 100 96.12 Very High Very High Very High
Keloid Scars 16 95.44 Very High Very High Very High
Burns 40 94.12 High High
Wound Healing 4 93.92 High High
Body Weight 2 81.04 Quite High
Alcoholic Cardiomyopathy 4 73.12 Quite High
Injury 9 58.48 Quite High
Coronary Heart Disease 4 50.00 Quite Low
Impaired Glucose Tolerance 10 35.68 Quite Low
Hyperinsulinism 1 33.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Contrary to the effect on LPO level, TSA level in MENK-treated mice was suppressed in both sexes but only in young 2.5-month-old mice.
Negative_regulation (suppressed) of TSA associated with enkephalin
1) Confidence 0.32 Published 2002 Journal Exp. Gerontol. Section Abstract Doc Link 12559410 Disease Relevance 0.08 Pain Relevance 0.81
To examine the effects of a histone deacetylase inhibitor, Trichostatin A (TSA), on the behavior of macrophages and subconjunctival fibroblasts in vitro and on ocular surface inflammation and scarring in vivo using an alkali burn wound healing model.


Spec (examine) Negative_regulation (inhibitor) of TSA in macrophages associated with inflammation, burns, wound healing and keloid scars
2) Confidence 0.28 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC3013068 Disease Relevance 0.65 Pain Relevance 0.18
However, therapeutic levels of TSA can be maintained in the eyes of patients via topical application of TSA.
Negative_regulation (application) of TSA in eyes
3) Confidence 0.24 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013068 Disease Relevance 0.44 Pain Relevance 0.15
1 expression by TSA is due to the reduction of collagen in TSA-culture.
Negative_regulation (reduction) of TSA
4) Confidence 0.24 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013068 Disease Relevance 0.15 Pain Relevance 0.08
However, therapeutic levels of TSA can be maintained in the eyes of patients via topical application of TSA.
Negative_regulation (maintained) of TSA in eyes
5) Confidence 0.24 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013068 Disease Relevance 0.44 Pain Relevance 0.15
Our data shown in Fig. 10 indicated that the short-term treatment of ethanol significantly decreased PS and ± dL/dt as well as prolonged TPS and TR90 without affecting resting cell length.
Negative_regulation (decreased) of TR90
6) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.07 Pain Relevance 0

General Comments

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