INT108250

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Context Info
Confidence 0.25
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 2.02
Pain Relevance 2.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prdx2) mitochondrion (Prdx2) oxidoreductase activity (Prdx2)
cytoplasm (Prdx2)
Anatomy Link Frequency
fat 1
Prdx2 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 10 99.60 Very High Very High Very High
endometriosis 2 99.60 Very High Very High Very High
fibrosis 14 99.08 Very High Very High Very High
Hyperalgesia 18 98.96 Very High Very High Very High
Inflammation 58 98.44 Very High Very High Very High
Thermal hyperalgesia 14 97.56 Very High Very High Very High
Spinal cord 39 90.40 High High
Pain 14 87.32 High High
ketamine 2 66.80 Quite High
anesthesia 6 51.68 Quite High
Disease Link Frequency Relevance Heat
Burns 22 99.68 Very High Very High Very High
Endometriosis (extended) 2 99.60 Very High Very High Very High
Fibrosis 16 99.08 Very High Very High Very High
Hyperalgesia 32 98.96 Very High Very High Very High
Cancer 4 98.68 Very High Very High Very High
INFLAMMATION 59 98.44 Very High Very High Very High
Necrosis 2 98.40 Very High Very High Very High
Pain 27 87.32 High High
Body Weight 4 81.88 Quite High
Nociception 18 77.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We finally examined the therapeutic effects of systemic administration of TSA on the ocular surface fibrosis induced in mice by the topical application of 0.5N NaOH.
Spec (examined) Regulation (effects) of TSA associated with fibrosis
1) Confidence 0.25 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013068 Disease Relevance 0.39 Pain Relevance 0.23
Effects of TSA on TGF?
Regulation (Effects) of TSA
2) Confidence 0.25 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013068 Disease Relevance 0 Pain Relevance 0
Contrary to the effect on LPO level, TSA level in MENK-treated mice was suppressed in both sexes but only in young 2.5-month-old mice.
Regulation (effect) of TSA associated with enkephalin
3) Confidence 0.20 Published 2002 Journal Exp. Gerontol. Section Abstract Doc Link 12559410 Disease Relevance 0.08 Pain Relevance 0.81
mice attempt to store rather than burn fat.

(4) An up-regulation of genes encoding key enzymatic and nonenzymatic low–molecular mass scavengers and antioxidant defense enzymes (e.g., Sod1, Prdx2 and 3, Txnip, Ephx1, Hmox1 and five components of the glutathione system) (Table 1), suggesting that Csbm/m/Xpa?

Regulation (regulation) of Prdx2 in fat associated with burns
4) Confidence 0.17 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1698505 Disease Relevance 0.16 Pain Relevance 0
BACKGROUND: The aim of this study was to evaluate the effect of trichostatin A (TSA) in a mouse model of endometriosis on serum tumour necrosis factor alpha (TNFalpha) levels, hotplate latency, lesion size and immunoreactivity to Trpv1, Pkcepsilon and Pgp9.5.
Regulation (effect) of TSA associated with endometriosis, necrosis and cancer
5) Confidence 0.10 Published 2010 Journal Hum. Reprod. Section Abstract Doc Link 20118114 Disease Relevance 0.45 Pain Relevance 0.16
Pre-injected inhibitors targeting class I as well as II (SAHA, TSA, LAQ824) or IIa (VPA, 4-PB) HDACs significantly delayed the thermal hyperalgesia induced by unilateral CFA injection in the hindpaw.
Regulation (targeting) of TSA associated with thermal hyperalgesia
6) Confidence 0.03 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2942827 Disease Relevance 0.94 Pain Relevance 0.88

General Comments

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