INT108252
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
For example, Mitrushina et al. [42] found that, whereas the left-right difference in performance did not vary with the age of the participants in a finger tapping test, the superiority of the dominant hand increased with age in the Pin test, a highly demanding task in terms of visuomotor coordination, attention, and precision of movement. | |||||||||||||||
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This could be an interesting issue since the brain undergoes considerable changes with advancing age, such as shrinkage of grey matter volume and white matter loss [15] as well as neural and functional reorganizations [16]. | |||||||||||||||
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In TSA levels, the age-associated increase was greater in males and much lower in females, with higher TSA levels in younger (2.5, 4.5 months) and decreased levels in older female mice (9 months) being observed. | |||||||||||||||
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Decreasing IOP correlates with increasing age in the human Japanese population [50,51]. | |||||||||||||||
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However, AGEs that are present extracellularly disrupt cellular adhesion and activate the AGE receptor (RAGE). | |||||||||||||||
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Consistent with increased AGE ligand levels in the diabetic heart, a significant increase in RAGE antigen by Western blotting was observed in diabetic compared with nondiabetic hearts (P < 0.05; Fig. 4A). | |||||||||||||||
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AGEs have in fact been identified in cancerous tissue, which leads to the possibility of AGE activation of RAGE contributing to cancer growth [172]. | |||||||||||||||
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The accumulation of AGE products in diabetes impairs EC function in animal models. | |||||||||||||||
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Consistent with increased AGE ligand levels in the diabetic heart, a significant increase in RAGE antigen by Western blotting was observed in diabetic compared with nondiabetic hearts (P < 0.05; Fig. 4A). | |||||||||||||||
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Examination of both HMGB1 and SGC in the developing mouse brain reveals that the amount of RAGE expressed in the cerebellum increases with age. | |||||||||||||||
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AGE accumulation itself is considered a source of oxidative stress. | |||||||||||||||
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AGE activation of RAGE is found in diabetes, neuodegeneration, and aging [168]. | |||||||||||||||
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for AGE (RAGE) and the scavenger receptor A (SR-A), which is responsible for | |||||||||||||||
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Yekta et al. showed an age dependency of quantitative sensory parameters in healthy probands, which demonstrated impairment of sensory function with increasing age [22]. | |||||||||||||||
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Furthermore, AGE accumulation was increased within the retinal extracellular matrix and attenuation of the RAGE axis with soluble RAGE ameliorated neuronal dysfunction and reduced the development of capillary lesions in these mice [7]. | |||||||||||||||
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Thus, AGE accumulation may induce receptor-mediated activation of RPE/photoreceptor cells, contributing to disease progression in the aging human retinas. | |||||||||||||||
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