INT108252

Context Info Confidence 0.24 First Reported 2001 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 16 Total Number 16 Disease Relevance 11.66 Pain Relevance 1.68

isomerase activity (Renbp)

Anatomy Link Frequency hearts 2 neuronal 1 left-right 1 retinas 1 brain 1 Renbp (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 86 96.60 Enkephalin 10 96.04 Inflammation 286 95.72 imagery 55 95.72 anesthesia 22 92.88 Pain 23 89.56 Quantitative sensory testing 32 80.32 unmyelinated 5 74.04 c fibre 2 64.12 diabetic neuropathy 12 60.56

Disease Link Frequency Relevance Heat Diabetes Mellitus 500 100.00 Adhesions 53 99.90 Ocular Hypertension 171 99.66 Cancer 129 99.00 Stress 132 98.24 Aging 71 97.88 Disease Progression 6 96.60 Thrombosis 4 96.36 INFLAMMATION 307 95.72 Age-related Macular Degeneration 16 95.24

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Key:

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Event

Anatomy

Negation

Speculation

Pain term

Disease term

For example, Mitrushina et al. [42] found that, whereas the left-right difference in performance did not vary with the age of the participants in a finger tapping test, the superiority of the dominant hand increased with age in the Pin test, a highly demanding task in terms of visuomotor coordination, attention, and precision of movement.

Positive_regulation (increased) of age in left-right

1) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2726952 Disease Relevance 0 Pain Relevance 0.03

This could be an interesting issue since the brain undergoes considerable changes with advancing age, such as shrinkage of grey matter volume and white matter loss [15] as well as neural and functional reorganizations [16].

Positive_regulation (advancing) of age in brain

2) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2726952 Disease Relevance 0.57 Pain Relevance 0.14

In TSA levels, the age-associated increase was greater in males and much lower in females, with higher TSA levels in younger (2.5, 4.5 months) and decreased levels in older female mice (9 months) being observed.

Positive_regulation (increase) of age

3) Confidence 0.16 Published 2002 Journal Exp. Gerontol. Section Abstract Doc Link 12559410 Disease Relevance 0.09 Pain Relevance 0.81

Decreasing IOP correlates with increasing age in the human Japanese population [50,51].

Positive_regulation (increasing) of age associated with ocular hypertension

4) Confidence 0.08 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 1.69 Pain Relevance 0.09

However, AGEs that are present extracellularly disrupt cellular adhesion and activate the AGE receptor (RAGE).

Positive_regulation (activate) of AGE associated with adhesions

5) Confidence 0.05 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.84 Pain Relevance 0.05

Consistent with increased AGE ligand levels in the diabetic heart, a significant increase in RAGE antigen by Western blotting was observed in diabetic compared with nondiabetic hearts (P < 0.05; Fig. 4A).

Positive_regulation (increased) of AGE in hearts associated with diabetes mellitus

6) Confidence 0.05 Published 2008 Journal Diabetes Section Body Doc Link PMC2453611 Disease Relevance 1.28 Pain Relevance 0

AGEs have in fact been identified in cancerous tissue, which leads to the possibility of AGE activation of RAGE contributing to cancer growth [172].

Positive_regulation (activation) of AGE associated with cancer

7) Confidence 0.04 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.69 Pain Relevance 0

The accumulation of AGE products in diabetes impairs EC function in animal models.

Positive_regulation (accumulation) of AGE associated with diabetes mellitus

8) Confidence 0.04 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 1.20 Pain Relevance 0.21

Consistent with increased AGE ligand levels in the diabetic heart, a significant increase in RAGE antigen by Western blotting was observed in diabetic compared with nondiabetic hearts (P < 0.05; Fig. 4A).

Positive_regulation (increase) of AGE in hearts associated with diabetes mellitus

9) Confidence 0.03 Published 2008 Journal Diabetes Section Body Doc Link PMC2453611 Disease Relevance 1.30 Pain Relevance 0

Examination of both HMGB1 and SGC in the developing mouse brain reveals that the amount of RAGE expressed in the cerebellum increases with age.

Positive_regulation (increases) of age in cerebellum

10) Confidence 0.03 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.65 Pain Relevance 0.12

AGE accumulation itself is considered a source of oxidative stress.

Positive_regulation (accumulation) of AGE associated with stress

11) Confidence 0.03 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.44 Pain Relevance 0

AGE activation of RAGE is found in diabetes, neuodegeneration, and aging [168].

Positive_regulation (activation) of AGE associated with aging and diabetes mellitus

12) Confidence 0.03 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.66 Pain Relevance 0

for AGE (RAGE) and the scavenger receptor A (SR-A), which is responsible for

Positive_regulation (for) of AGE

13) Confidence 0.02 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 0.67 Pain Relevance 0.05

Yekta et al. showed an age dependency of quantitative sensory parameters in healthy probands, which demonstrated impairment of sensory function with increasing age [22].

Positive_regulation (increasing) of age

14) Confidence 0.01 Published 2010 Journal Head Face Med Section Body Doc Link PMC2984556 Disease Relevance 0.05 Pain Relevance 0.18

Furthermore, AGE accumulation was increased within the retinal extracellular matrix and attenuation of the RAGE axis with soluble RAGE ameliorated neuronal dysfunction and reduced the development of capillary lesions in these mice [7].

Positive_regulation (accumulation) of AGE in neuronal

15) Confidence 0.01 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647152 Disease Relevance 0.82 Pain Relevance 0

Thus, AGE accumulation may induce receptor-mediated activation of RPE/photoreceptor cells, contributing to disease progression in the aging human retinas.

Positive_regulation (accumulation) of AGE in retinas associated with aging and disease progression

16) Confidence 0.01 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647152 Disease Relevance 0.71 Pain Relevance 0

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