INT108253

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Context Info
Confidence 0.47
First Reported 2001
Last Reported 2002
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 1.19
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Lpo) cellular_component (Lpo) biological_process (Lpo)
Lpo (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 10 99.98 Very High Very High Very High
Nicotine 4 43.12 Quite Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Body Weight 1 98.92 Very High Very High Very High
Stress 56 84.60 Quite High
Nicotine Addiction 20 78.80 Quite High
Genetic Predisposition To Disease 4 55.52 Quite High
Disease 20 53.52 Quite High
Cancer 8 50.28 Quite High
Increased Venous Pressure Under Development 4 9.16 Low Low
Pulmonary Disease 4 8.36 Low Low
Exsanguination 4 5.00 Very Low Very Low Very Low
Burns 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our studies, a significant decrease in the GSH levels was observed in both the smoked as well as AT + smoked groups and concomitantly there was an increase in the LPO levels.
Positive_regulation (increase) of Gene_expression (levels) of LPO
1) Confidence 0.47 Published 2001 Journal BMC Biochem Section Body Doc Link PMC60661 Disease Relevance 0.22 Pain Relevance 0
It was also observed that as the exposure to CS was extended from 4 to 6 and then to 8 weeks, there was a corresponding increase in the pulmonary LPO levels in both, the smoked as well as the AT + smoked group.
Positive_regulation (increase) of Gene_expression (levels) of LPO
2) Confidence 0.47 Published 2001 Journal BMC Biochem Section Body Doc Link PMC60661 Disease Relevance 0.28 Pain Relevance 0
At the higher dose, MENK stimulated LPO production in younger males and females but suppressed only in older male mice.
Positive_regulation (stimulated) of Gene_expression (production) of LPO associated with enkephalin
3) Confidence 0.43 Published 2002 Journal Exp. Gerontol. Section Abstract Doc Link 12559410 Disease Relevance 0.10 Pain Relevance 0.75
In this phase of study it was observed that CS inhalation triggered LPO both in smoked and AT + smoked group.
Positive_regulation (triggered) of Gene_expression (triggered) of LPO
4) Confidence 0.41 Published 2001 Journal BMC Biochem Section Body Doc Link PMC60661 Disease Relevance 0.21 Pain Relevance 0
However, the extent of the increase in the pulmonary LPO levels in the AT + smoked group was comparatively low as compared to the animals not fed with AT and only exposed to CS.
Positive_regulation (increase) of Gene_expression (levels) of LPO
5) Confidence 0.38 Published 2001 Journal BMC Biochem Section Body Doc Link PMC60661 Disease Relevance 0.38 Pain Relevance 0

General Comments

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