INT108260

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Context Info
Confidence 0.54
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 10.77
Pain Relevance 5.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
urinary bladder 2
microglial cells 2
nerves 2
paw 1
neurons 1
Par2 (Mus musculus)
Pain Link Frequency Relevance Heat
bradykinin 15 100.00 Very High Very High Very High
Pain 28 99.92 Very High Very High Very High
Inflammation 237 99.20 Very High Very High Very High
qutenza 88 99.14 Very High Very High Very High
adenocard 2 99.00 Very High Very High Very High
Nerve growth factor 45 98.72 Very High Very High Very High
substance P 37 98.24 Very High Very High Very High
opiate 2 98.16 Very High Very High Very High
agonist 59 98.08 Very High Very High Very High
cytokine 12 96.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 31 99.92 Very High Very High Very High
Nociception 69 99.48 Very High Very High Very High
INFLAMMATION 260 99.20 Very High Very High Very High
Targeted Disruption 34 98.64 Very High Very High Very High
Pneumonia 11 98.32 Very High Very High Very High
Pressure And Volume Under Development 7 98.04 Very High Very High Very High
Skin Allergy 2 97.64 Very High Very High Very High
Coagulation Disorder 13 97.04 Very High Very High Very High
Heart Rate Under Development 2 96.88 Very High Very High Very High
Pruritus 18 95.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These represent a novel mechanism through which trypsin or tryptase released in response to tissue inflammation might trigger the sensation of pain by PAR2 activation.
Positive_regulation (activation) of PAR2 associated with pain and inflammation
1) Confidence 0.54 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15128843 Disease Relevance 0.40 Pain Relevance 0.53
The SMWE (10 mg/kg) significantly also inhibited PAR2 agonist-induced myeloperoxidase (MPO) activity and tumor necrosis factor (TNF)-alpha expression in paw tissue.
Positive_regulation (agonist-induced) of PAR2 in paw
2) Confidence 0.45 Published 2003 Journal Clin. Chim. Acta Section Body Doc Link 12559597 Disease Relevance 0 Pain Relevance 0
Thus, PAR2 activation in the lung induces airway constriction, lung inflammation, and protein-rich pulmonary edema.
Positive_regulation (activation) of PAR2 in lung associated with heart rate under development, inflammation and pneumonia
3) Confidence 0.44 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16081834 Disease Relevance 0.55 Pain Relevance 0.40
In bronchoalveolar lavage, PAR2 activation caused 8- and 5-fold increase in MIP-2 and substance P levels, respectively, and a 12-fold increase in the number of neutrophils.
Positive_regulation (activation) of PAR2 in neutrophils associated with substance p
4) Confidence 0.44 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16081834 Disease Relevance 0.46 Pain Relevance 0.34
The requirement of TF as a co-receptor for PAR1 and PAR2 activation is likely to be a key determinant [37].
Positive_regulation (activation) of PAR2
5) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2211395 Disease Relevance 0.70 Pain Relevance 0.20
Although thrombin is a recognized physiological activator of PAR1 and PAR4, the endogenous enzymes responsible for activating PAR2 in urinary bladder are not known.
Positive_regulation (activating) of PAR2 in urinary bladder
6) Confidence 0.34 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.32 Pain Relevance 0.08
Out of 345 TFs present in this array, only TFEB was shared by PAR1-, PAR2-, and PAR4 activation.
Positive_regulation (activation) of PAR2
7) Confidence 0.32 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.35 Pain Relevance 0.17
Serine proteases such as tryptase and their respective proteinase-activating receptor 2 (PAR2), recently found in both skin and nerves of patients with atopic eczema, suggest that these molecules may have a role in itch in dry skin.
Positive_regulation (respective) of PAR2 in nerves associated with skin allergy and pruritus
8) Confidence 0.32 Published 2004 Journal Int J Cosmet Sci Section Abstract Doc Link 18494919 Disease Relevance 1.14 Pain Relevance 0.26
Although thrombin is a recognized physiological activator of PAR1 and PAR4, the endogenous enzymes responsible for activating PAR2 in urinary bladder are not known.
Positive_regulation (activating) of PAR2 in urinary bladder
9) Confidence 0.27 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 0.47 Pain Relevance 0.25
from the cytoplasm to the surface membrane [21], and a similar translocation has been reported in response to activation of PAR2 [22].
Positive_regulation (activation) of PAR2
10) Confidence 0.25 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0.55 Pain Relevance 0.20
Activation of PAR2 receptors is well known to cause inflammation [19] but a role for PAR1 and 4 is less clear.
Positive_regulation (Activation) of PAR2 associated with inflammation
11) Confidence 0.23 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0.45 Pain Relevance 0.47
Activation of the heat and capsaicin gated ion channel TRPV1 is potentiated by PAR2 activation [22].
Positive_regulation (activation) of PAR2 associated with qutenza
12) Confidence 0.23 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0.06 Pain Relevance 0.17
Activation of PAR1, PAR2 and PAR4 either by proteinases or by selective agonists causes inflammation inducing most of the cardinal signs of inflammation: swelling, redness, and pain.
Positive_regulation (Activation) of PAR2 associated with pain, pressure and volume under development, inflammation and agonist
13) Confidence 0.16 Published 2005 Journal Mem. Inst. Oswaldo Cruz Section Abstract Doc Link 15962118 Disease Relevance 1.30 Pain Relevance 0.91
Four PAR'S have been identified (PAR 1–4); PAR'S 1,3 and 4 are activated by thrombin while PAR2 is activated by trypsin [30].
Positive_regulation (activated) of PAR2
14) Confidence 0.15 Published 2002 Journal BMC Dev Biol Section Body Doc Link PMC65692 Disease Relevance 0.08 Pain Relevance 0
Serine proteases such as tryptase and their respective proteinase-activating receptor 2 (PAR2), recently found in both skin and nerves of patients with atopic eczema, suggest that these molecules may have a role in itch in dry skin.
Positive_regulation (respective) of PAR2 in skin associated with skin allergy and pruritus
15) Confidence 0.11 Published 2004 Journal Int J Cosmet Sci Section Abstract Doc Link 18494919 Disease Relevance 1.14 Pain Relevance 0.26
Supernatants from the biopsies produced neurological symptoms when introduced into gastrointestinal tracts of mice by hypersensitizing neurons through the protease-activated (PAR2) pathway.
Positive_regulation (activated) of PAR2 in neurons
16) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2987810 Disease Relevance 0.93 Pain Relevance 0.68
Mast cell-derived tryptase activated PAR2 that resulted in promoting the expression of P2X4R in microglial cells.
Positive_regulation (derived) of PAR2 in microglial cells
17) Confidence 0.08 Published 2010 Journal J. Neurosci. Res. Section Abstract Doc Link 20025063 Disease Relevance 0.47 Pain Relevance 0.29
Mast cell-derived tryptase activated PAR2 that resulted in promoting the expression of P2X4R in microglial cells.
Positive_regulation (activated) of PAR2 in microglial cells
18) Confidence 0.08 Published 2010 Journal J. Neurosci. Res. Section Abstract Doc Link 20025063 Disease Relevance 0.47 Pain Relevance 0.28
Protease-activated receptor-1 (PAR1), PAR2 and PAR4 activation can alter the gastrointestinal motility.
Positive_regulation (activation) of PAR2
19) Confidence 0.07 Published 2007 Journal Regul. Pept. Section Abstract Doc Link 17335921 Disease Relevance 0 Pain Relevance 0.04
Stimulation of a PKC phosphorylation pathway could link TRPV1 mediated pulmonary responses with the upstream activation of cell surface receptors such as the purinergic receptor P2Y1, bradykinin BK2 receptor, PAR2, histamine H1 receptor, or the nerve growth factor (NGF) receptor TrkA [6-8,30].
Positive_regulation (activation) of PAR2 in nerve associated with nerve growth factor and bradykinin
20) Confidence 0.06 Published 2006 Journal Cough Section Body Doc Link PMC1764418 Disease Relevance 0.31 Pain Relevance 0.43

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