INT108263

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Context Info
Confidence 0.52
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 12.89
Pain Relevance 2.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mpo) extracellular space (Mpo) oxidoreductase activity (Mpo)
lysosome (Mpo)
Anatomy Link Frequency
lung 7
kidney 4
neutrophil 4
paw 2
keratinocyte 2
Mpo (Mus musculus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 6 99.04 Very High Very High Very High
Inflammation 272 97.64 Very High Very High Very High
qutenza 6 92.56 High High
substance P 4 90.80 High High
Angina 5 89.36 High High
cytokine 165 89.08 High High
imagery 2 87.96 High High
antagonist 35 87.68 High High
metalloproteinase 9 79.60 Quite High
Neuropeptide 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 102 100.00 Very High Very High Very High
Targeted Disruption 93 99.96 Very High Very High Very High
Myocardial Infarction 86 99.96 Very High Very High Very High
Infection 98 98.76 Very High Very High Very High
INFLAMMATION 300 97.64 Very High Very High Very High
Death 43 97.64 Very High Very High Very High
Acute Coronary Syndrome 10 95.52 Very High Very High Very High
Burns 113 94.88 High High
Multiple Sclerosis 6 91.92 High High
Injury 132 91.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Correspondingly, there was a trend toward a decrease in MPO levels in the lung, liver, kidney of PAF-treated endotoxemic mice.
Negative_regulation (decrease) of Gene_expression (levels) of MPO in kidney associated with urological neuroanatomy
1) Confidence 0.52 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714981 Disease Relevance 0.76 Pain Relevance 0.06
CGRP(8-37) or combination of SR 140333 and SR 48968 diminished neutrophil accumulation, MPO levels and IL-1beta production, airway hyperresponsiveness was inhibited only by SR 48968.
Negative_regulation (diminished) of Gene_expression (production) of MPO in neutrophil associated with urological neuroanatomy and calcitonin gene-related peptide
2) Confidence 0.41 Published 2007 Journal Regul. Pept. Section Abstract Doc Link 17291600 Disease Relevance 0.61 Pain Relevance 1.05
Significant reduction in plasma tumor necrosis factor-alpha and keratinocyte-derived chemokine, as well as reductions in myeloperoxidase activity, intracellular adhesion molecule-1 protein expression, mRNA concentrations of proinflammatory markers, and apoptosis were observed in renal cortices from both local anesthetic groups.
Negative_regulation (reductions) of Gene_expression (expression) of myeloperoxidase in keratinocyte
3) Confidence 0.39 Published 2004 Journal Anesthesiology Section Body Doc Link 15448523 Disease Relevance 0.13 Pain Relevance 0
Measurement of myeloperoxidase activity
Negative_regulation (Measurement) of Gene_expression (activity) of myeloperoxidase
4) Confidence 0.38 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2844385 Disease Relevance 0.18 Pain Relevance 0.09
In accordance with the results on reduced percentages of affected lung, we found a trend towards reduced MPO levels in OPN KO lungs at 24 h (P?
Negative_regulation (reduced) of Gene_expression (levels) of MPO in lung associated with targeted disruption and urological neuroanatomy
5) Confidence 0.37 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2930856 Disease Relevance 2.83 Pain Relevance 0.24
One unit of MPO activity was defined as the quantity of MPO degrading 1 ?
Negative_regulation (defined) of Gene_expression (quantity) of MPO associated with urological neuroanatomy
6) Confidence 0.34 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819555 Disease Relevance 0.81 Pain Relevance 0.06
Determination of lung myeloperoxidase activity
Negative_regulation (Determination) of Gene_expression (activity) of lung myeloperoxidase in lung
7) Confidence 0.34 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 0.19 Pain Relevance 0
In addition, simvastatin lowered MPO mRNA and enzyme activity even after 1 day in human MPO overexpressing transgenic mice fed drug for 1- 21 days [95].
Negative_regulation (lowered) of Gene_expression (overexpressing) of MPO associated with targeted disruption and urological neuroanatomy
8) Confidence 0.29 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644496 Disease Relevance 0.99 Pain Relevance 0.17
0.10) and significantly diminished MPO levels in OPN KO lungs at 72 h after infection (figure 4I, P<0.05).


Negative_regulation (diminished) of Gene_expression (levels) of MPO in lungs associated with targeted disruption, urological neuroanatomy and infection
9) Confidence 0.27 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2930856 Disease Relevance 2.80 Pain Relevance 0.20
The SMWE (10 mg/kg) significantly also inhibited PAR2 agonist-induced myeloperoxidase (MPO) activity and tumor necrosis factor (TNF)-alpha expression in paw tissue.
Negative_regulation (inhibited) of Gene_expression (expression) of MPO in paw
10) Confidence 0.23 Published 2003 Journal Clin. Chim. Acta Section Body Doc Link 12559597 Disease Relevance 0 Pain Relevance 0
It also found that after an AMI, MPO levels peak early, then decrease over time and do not correlate with Troponin or the neutrophil count.
Neg (not) Negative_regulation (decrease) of Gene_expression (levels) of MPO in neutrophil associated with urological neuroanatomy and myocardial infarction
11) Confidence 0.23 Published 2010 Journal BMC Med Section Body Doc Link PMC2898678 Disease Relevance 2.07 Pain Relevance 0.22
Correspondingly, there was a trend toward a decrease in MPO levels in the lung, liver, kidney of PAF-treated endotoxemic mice.
Negative_regulation (decrease) of in liver Gene_expression (levels) of MPO in kidney associated with urological neuroanatomy
12) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714981 Disease Relevance 0.76 Pain Relevance 0.06
Correspondingly, there was a trend toward a decrease in MPO levels in the lung, liver, kidney of PAF-treated endotoxemic mice.
Negative_regulation (decrease) of in lung Gene_expression (levels) of MPO in kidney associated with urological neuroanatomy
13) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714981 Disease Relevance 0.76 Pain Relevance 0.06

General Comments

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