INT10827

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Context Info
Confidence 0.78
First Reported 1992
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 16
Total Number 18
Disease Relevance 13.08
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apob) extracellular space (Apob) endoplasmic reticulum (Apob)
enzyme binding (Apob) lipid metabolic process (Apob)
Anatomy Link Frequency
plasma 3
liver 2
adipocytes 2
Blood 1
Caco-2 1
Apob (Mus musculus)
Pain Link Frequency Relevance Heat
Catecholamine 24 97.16 Very High Very High Very High
Potency 55 95.04 Very High Very High Very High
alcohol 10 93.04 High High
Restless leg syndrome 1 90.52 High High
noradrenaline 28 88.88 High High
Angina 6 88.08 High High
Inflammation 70 83.76 Quite High
fibrosis 35 81.44 Quite High
agonist 4 60.56 Quite High
psoriasis 189 56.08 Quite High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 242 100.00 Very High Very High Very High
Targeted Disruption 65 99.98 Very High Very High Very High
Psoriasis 318 99.64 Very High Very High Very High
Cardiovascular Disease 133 99.32 Very High Very High Very High
Obesity 205 99.04 Very High Very High Very High
Hyperlipidemia 141 98.88 Very High Very High Very High
Hyperlipoproteinemia Type Ii 292 96.28 Very High Very High Very High
Hepatotoxicity 48 95.80 Very High Very High Very High
Diabetes Mellitus 37 95.28 Very High Very High Very High
Nicotine Addiction 16 93.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A line of mice expressing a human apolipoprotein B (APOB) gene fail to deliver their young if the transgene is present in homozygous (Tg/Tg), but not in heterozygous (Tg/Wt), form.
Gene_expression (expressing) of apolipoprotein B associated with disorder of lipid metabolism
1) Confidence 0.78 Published 2005 Journal Biol. Reprod. Section Abstract Doc Link 16034000 Disease Relevance 0.10 Pain Relevance 0
A line of mice expressing a human apolipoprotein B (APOB) gene fail to deliver their young if the transgene is present in homozygous (Tg/Tg), but not in heterozygous (Tg/Wt), form.
Gene_expression (expressing) of APOB associated with disorder of lipid metabolism
2) Confidence 0.78 Published 2005 Journal Biol. Reprod. Section Abstract Doc Link 16034000 Disease Relevance 0.10 Pain Relevance 0
Types of apoB and lipolysis in mouse adipocytes
Gene_expression (Types) of apoB in adipocytes associated with obesity
3) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582480 Disease Relevance 0.46 Pain Relevance 0.15
In subcutaneous fat cells, the rate of lipolysis was inversely related to plasma apoB levels.
Gene_expression (levels) of apoB in fat cells associated with obesity
4) Confidence 0.58 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2582480 Disease Relevance 0.86 Pain Relevance 0.04
For the ApoB target, ASOs were dosed at 2.5 and either 0.5 or 0.4 ?
Gene_expression (target) of ApoB
5) Confidence 0.29 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1802611 Disease Relevance 0.43 Pain Relevance 0.18
Many authors did not show any differences in apoA1, apoA2, and apoB levels between psoriatic patients and the control group [10, 76, 80].
Gene_expression (levels) of apoB associated with psoriasis
6) Confidence 0.24 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2914266 Disease Relevance 1.16 Pain Relevance 0.03
The transgenic apoB mice that express human apoB have similar plasma concentrations to those of normolipidemic humans when fed on normal diet [26].
Gene_expression (express) of apoB in plasma associated with targeted disruption
7) Confidence 0.23 Published 2010 Journal The Open Neurology Journal Section Body Doc Link PMC2928914 Disease Relevance 0.85 Pain Relevance 0
The transgenic apoB mice that express human apoB have similar plasma concentrations to those of normolipidemic humans when fed on normal diet [26].
Gene_expression (express) of apoB in plasma associated with targeted disruption
8) Confidence 0.23 Published 2010 Journal The Open Neurology Journal Section Body Doc Link PMC2928914 Disease Relevance 0.85 Pain Relevance 0
T+294C SNP is associated with elevated plasma LDL cholesterol and apoB levels in men and we show in this work that similar associations are operating in women, we also looked for a potential gene-to-gene interaction between PPAR?
Gene_expression (levels) of apoB in plasma
9) Confidence 0.23 Published 2006 Journal International Journal of Medical Sciences Section Body Doc Link PMC1525216 Disease Relevance 0.62 Pain Relevance 0.03
Table 2 shows the results for a pooled analysis of all ezetimibe plus statin doses for changes from baseline in TC, apolipoprotein B-100 (apoB), TG, and high-density lipoprotein cholesterol (HDL-C) levels.1
Gene_expression (apolipoprotein B-100) of apoB associated with disorder of lipid metabolism
10) Confidence 0.19 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988620 Disease Relevance 0.63 Pain Relevance 0
Although this trial showed no benefit in reducing CIMT by the combination of simvastatin and ezetimibe, it did show the expected lowering of LDL-C and apoB levels.
Gene_expression (levels) of apoB
11) Confidence 0.19 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988620 Disease Relevance 0.21 Pain Relevance 0
In most studies, elevated levels of apoA1, apoB [16, 43], apoC3, and apoE [41, 76–78] were detected in the serum of psoriatic patients compared to the healthy control group.
Gene_expression (detected) of apoB associated with psoriasis
12) Confidence 0.19 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2914266 Disease Relevance 1.05 Pain Relevance 0.03
In most studies, elevated levels of apoA1, apoB [16, 43], apoC3, and apoE [41, 76–78] were detected in the serum of psoriatic patients compared to the healthy control group.
Gene_expression (levels) of apoB associated with psoriasis
13) Confidence 0.19 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2914266 Disease Relevance 1.08 Pain Relevance 0.03
In contrast, the ApoB-editing enzyme is not expressed in the liver of rabbits [80], but murine models do have ApoB-editing activity in the liver [81].
Neg (not) Gene_expression (expressed) of ApoB in liver
14) Confidence 0.16 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.91 Pain Relevance 0
In contrast, the ApoB-editing enzyme is not expressed in the liver of rabbits [80], but murine models do have ApoB-editing activity in the liver [81].
Neg (not) Gene_expression (expressed) of ApoB in liver
15) Confidence 0.14 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.93 Pain Relevance 0
While the majority of studies were focused on treating FH by inhibition of hypercholesterolaemia through up-regulation of LDLR or other surrogate lipoprotein receptors (as will be discussed later), an alternative approach was to down-regulate apoB-100 LDLR-ligand or PCSK9 [63] expression.
Gene_expression (expression) of apoB associated with hyperlipoproteinemia type ii and hyperlipidemia
16) Confidence 0.14 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.36 Pain Relevance 0
As demonstrated previously, CFTR depletion in Caco-2/15 cells has led to the enhancement of apolipoprotein B biosynthesis and the assembly of CM.
Gene_expression (biosynthesis) of apolipoprotein B in Caco-2 associated with disorder of lipid metabolism
17) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0.98 Pain Relevance 0.19
Blood pressure, low density lipoprotein (LDL)-cholesterol and the apolipoproteins A1 and B rose while high density lipoprotein (HDL)-cholesterol, the HDL-cholesterol/apolipoprotein A1 and the LDL-cholesterol/apolipoprotein B ratios decreased significantly with increasing exposure.
Gene_expression (decreased) of apolipoprotein B in Blood associated with disorder of lipid metabolism
18) Confidence 0.01 Published 1992 Journal Int J Epidemiol Section Abstract Doc Link 1521980 Disease Relevance 1.39 Pain Relevance 0.23

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