INT108273

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Context Info
Confidence 0.65
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.29
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Phgdh)
Anatomy Link Frequency
chorion 1
uterus 1
dopaminergic neurons 1
Phgdh (Mus musculus)
Pain Link Frequency Relevance Heat
Cannabinoid 7 99.74 Very High Very High Very High
Arthritis 40 98.48 Very High Very High Very High
cytokine 105 96.48 Very High Very High Very High
metalloproteinase 51 87.72 High High
substance P 22 85.44 High High
addiction 1 80.40 Quite High
agonist 33 74.04 Quite High
parabrachial 1 67.84 Quite High
antagonist 10 59.32 Quite High
chemokine 9 52.32 Quite High
Disease Link Frequency Relevance Heat
Arthritis 42 98.48 Very High Very High Very High
Disease 35 98.24 Very High Very High Very High
Cognitive Disorder 1 97.16 Very High Very High Very High
Pre-term Labor 120 96.16 Very High Very High Very High
Dengue 13 95.72 Very High Very High Very High
Stress 4 95.04 Very High Very High Very High
Autoimmune Disease 8 84.24 Quite High
Cerebral Palsy 6 82.28 Quite High
Idiopathic Thrombocytopenic Purpura 1 81.40 Quite High
Periventricular Leukomalacia 3 80.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The two positive controls (CHIKV IgM human sera with a titre of 1?
Gene_expression (human) of sera
1) Confidence 0.65 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2907414 Disease Relevance 0.25 Pain Relevance 0
The same was found for the anti-GPI sera transfer model.
Gene_expression (transfer) of sera
2) Confidence 0.58 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 0.74 Pain Relevance 0.17
Cannabinoid-induced Fos expression within A10 dopaminergic neurons.
Gene_expression (expression) of A10 in dopaminergic neurons associated with cannabinoid
3) Confidence 0.19 Published 2003 Journal Brain Res. Section Title Doc Link 12560108 Disease Relevance 0.19 Pain Relevance 0.46
-induced decreases in chorion PGDH expression [56].
Gene_expression (expression) of PGDH in chorion
4) Confidence 0.11 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305338 Disease Relevance 0.97 Pain Relevance 0.07
Although the amnion produces significant quantities of PGE2 during pregnancy, there is little effect of this hormone on the uterus or cervix because the chorion and trophoblast produce an enzyme, 15-hydroxyprostaglandin dehydrogenase (PGDH), which converts PGE2 and PGF2?
Gene_expression (produce) of PGDH in uterus
5) Confidence 0.09 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305338 Disease Relevance 0.08 Pain Relevance 0.38
have been shown to inhibit the production of PGDH [54-56], which may contribute to increased prostaglandin production during labor.


Gene_expression (production) of PGDH
6) Confidence 0.08 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305338 Disease Relevance 0.07 Pain Relevance 0.32
With the exception of A10 (L21027) and EGF (J00380) that were associated with both matrixes, a unique set of genes is correlated with Nkx-2.5 matrix _01 and Nkx-2.5 matrix _02.


Neg (exception) Gene_expression (exception) of A10
7) Confidence 0.07 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0 Pain Relevance 0.08

General Comments

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