INT10828

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Context Info
Confidence 0.39
First Reported 1992
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 7.55
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apob) extracellular space (Apob) endoplasmic reticulum (Apob)
enzyme binding (Apob) lipid metabolic process (Apob)
Anatomy Link Frequency
body 2
plasma 1
liver 1
Apob (Mus musculus)
Pain Link Frequency Relevance Heat
Catecholamine 12 97.20 Very High Very High Very High
alcohol 5 97.02 Very High Very High Very High
Potency 106 95.04 Very High Very High Very High
Restless leg syndrome 2 79.48 Quite High
noradrenaline 14 77.84 Quite High
Angina 2 77.04 Quite High
psoriasis 63 55.52 Quite High
Inflammation 26 8.32 Low Low
Bile 14 5.00 Very Low Very Low Very Low
cva 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 97 100.00 Very High Very High Very High
Psoriasis 106 99.36 Very High Very High Very High
Obesity 92 98.72 Very High Very High Very High
Hyperlipidemia 51 98.44 Very High Very High Very High
Stress 18 97.42 Very High Very High Very High
Nicotine Addiction 6 96.84 Very High Very High Very High
Hyperlipoproteinemia Type Ii 132 96.46 Very High Very High Very High
Hepatotoxicity 84 95.80 Very High Very High Very High
Cardiovascular Disease 25 95.16 Very High Very High Very High
Targeted Disruption 38 88.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We hypothesized that apoB-containing lipoproteins affect adipocyte lipolysis, serving as a signal from the liver to peripheral fat deposits.
Spec (hypothesized) Regulation (affect) of apoB-containing in liver
1) Confidence 0.39 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582480 Disease Relevance 0.75 Pain Relevance 0.09
Three active ASO sequences (6, 8 and 9, Table 1) targeting either mouse ApoB or mouse PTEN were identified in cell culture assays using methods previously described for these targets.
Regulation (targeting) of ApoB
2) Confidence 0.12 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1802611 Disease Relevance 0.49 Pain Relevance 0.13
For the ApoB target, ASOs were dosed at 2.5 and either 0.5 or 0.4 ?
Regulation (target) of ApoB
3) Confidence 0.12 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1802611 Disease Relevance 0.43 Pain Relevance 0.18
ApoB is the major protein directing the metabolic fate of both VLDL and LDL, and its increased plasma concentrations are associated with the development of cardiovascular diseases.
Regulation (directing) of ApoB in plasma associated with cardiovascular disease
4) Confidence 0.11 Published 2010 Journal The Open Neurology Journal Section Body Doc Link PMC2928914 Disease Relevance 0.84 Pain Relevance 0
While the majority of studies were focused on treating FH by inhibition of hypercholesterolaemia through up-regulation of LDLR or other surrogate lipoprotein receptors (as will be discussed later), an alternative approach was to down-regulate apoB-100 LDLR-ligand or PCSK9 [63] expression.
Regulation (regulate) of apoB associated with hyperlipoproteinemia type ii and hyperlipidemia
5) Confidence 0.09 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.35 Pain Relevance 0
Down-regulation of apoB-100 by continues intravenous/subcutaneous administration of Mipomersen antisense apolipoprotein B-100 oligonucleotide had been attempted in several clinical trials achieving average LDL-C reduction of 36-37%.
Regulation (regulation) of apoB associated with disorder of lipid metabolism
6) Confidence 0.09 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.36 Pain Relevance 0
Many authors did not show any differences in apoA1, apoA2, and apoB levels between psoriatic patients and the control group [10, 76, 80].
Neg (not) Regulation (differences) of apoB associated with psoriasis
7) Confidence 0.07 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2914266 Disease Relevance 1.22 Pain Relevance 0.03
Adjustment for age, body mass index, smoking, alcohol consumption, stress and tension at work, shift work, noise exposure and educational level in multiple linear regression analysis showed significant effects of the CS2 index on systolic BP, diastolic BP, cholesterol, HDL-cholesterol, LDL-cholesterol, apolipoprotein A1, apolipoprotein B, the LDL cholesterol/apolipoprotein B and HDL cholesterol/apolipoprotein A1 ratios; there were no significant effects on the triglycerides.
Regulation (effects) of apolipoprotein B in body associated with stress, nicotine addiction, obesity, disorder of lipid metabolism and alcohol
8) Confidence 0.01 Published 1992 Journal Int J Epidemiol Section Abstract Doc Link 1521980 Disease Relevance 1.55 Pain Relevance 0.21
Adjustment for age, body mass index, smoking, alcohol consumption, stress and tension at work, shift work, noise exposure and educational level in multiple linear regression analysis showed significant effects of the CS2 index on systolic BP, diastolic BP, cholesterol, HDL-cholesterol, LDL-cholesterol, apolipoprotein A1, apolipoprotein B, the LDL cholesterol/apolipoprotein B and HDL cholesterol/apolipoprotein A1 ratios; there were no significant effects on the triglycerides.
Regulation (effects) of apolipoprotein B in body associated with stress, nicotine addiction, obesity, disorder of lipid metabolism and alcohol
9) Confidence 0.01 Published 1992 Journal Int J Epidemiol Section Abstract Doc Link 1521980 Disease Relevance 1.56 Pain Relevance 0.21

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