INT10830

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Context Info
Confidence 0.44
First Reported 1992
Last Reported 2011
Negated 4
Speculated 2
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 15.10
Pain Relevance 3.04

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lipid binding (Apoa1) transport (Apoa1) extracellular space (Apoa1)
extracellular region (Apoa1) nucleus (Apoa1) enzyme binding (Apoa1)
Anatomy Link Frequency
body 2
Apoa1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 42 100.00 Very High Very High Very High
Inflammatory response 6 100.00 Very High Very High Very High
Multiple sclerosis 288 99.56 Very High Very High Very High
rheumatoid arthritis 102 98.60 Very High Very High Very High
headache 1 97.52 Very High Very High Very High
cytokine 49 97.08 Very High Very High Very High
alcohol 8 97.02 Very High Very High Very High
Inflammation 66 96.68 Very High Very High Very High
Demyelination 12 93.32 High High
Sciatic nerve 6 83.20 Quite High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 85 100.00 Very High Very High Very High
INFLAMMATION 72 100.00 Very High Very High Very High
Demyelinating Disease 354 99.56 Very High Very High Very High
Autoimmune Disease 48 99.40 Very High Very High Very High
Systemic Lupus Erythematosus 114 98.92 Very High Very High Very High
Rheumatoid Arthritis 102 98.60 Very High Very High Very High
Disease 61 98.52 Very High Very High Very High
Cv Unclassified Under Development 3 98.16 Very High Very High Very High
Headache 1 97.52 Very High Very High Very High
Stress 4 97.42 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we found age at onset have a significantly effect on serum apoA-I levels in MS patients relative to other lipid indicators (TG, HDL-C, LDL-C, apoB100), which show that apoA-I is not only associated with serum lipid metabolism, but with the pathogenesis of MS.
Regulation (effect) of apoA-I associated with multiple sclerosis and disorder of lipid metabolism
1) Confidence 0.44 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2860353 Disease Relevance 1.85 Pain Relevance 0.47
In order to clarify the effect of CNS inflammatory response on serum apoA-I levels, we compare neuroinflammation patients with MS patients, This study further confirmed that, compared to other CNS inflammatory diseases, the imbalance between demyelination and regeneration in MS patients may be related to elevated serum apoA-I concentrations.
Regulation (effect) of apoA-I associated with demyelination, multiple sclerosis, inflammatory response, inflammation, central nervous system and disease
2) Confidence 0.44 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2860353 Disease Relevance 1.63 Pain Relevance 0.72
Table 1 shown age at onset had little effect on serum apoA-I levels, however, different kinds of diseases (P < 0.001) and gender (P < 0.05) have different levels of serum, therefore, we first compared apoA-I levels in different disease groups not taking into account gender and age factors.
Neg (little) Regulation (effect) of apoA-I associated with disease
3) Confidence 0.27 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2860353 Disease Relevance 1.11 Pain Relevance 0.19
To analyze the effect of age, gender and different entity on serum apoA-I levels in different groups, comparison of serum apoA-I levels among all male or female patients, comparison of serum apoA-I levels between male and female patients in each group using the Multivarite ANOVA.
Spec (analyze) Regulation (effect) of apoA-I
4) Confidence 0.27 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2860353 Disease Relevance 1.02 Pain Relevance 0.18
However, the change of serum apoA-I levels in multiple sclerosis (MS) patients is unknown.


Regulation (change) of apoA-I associated with multiple sclerosis
5) Confidence 0.27 Published 2010 Journal Lipids Health Dis Section Abstract Doc Link PMC2860353 Disease Relevance 1.60 Pain Relevance 0.35
For all patients, age had no effect on serum apoA-I levels (P > 0.05).
Neg (no) Regulation (effect) of apoA-I
6) Confidence 0.27 Published 2010 Journal Lipids Health Dis Section Abstract Doc Link PMC2860353 Disease Relevance 1.88 Pain Relevance 0.39
In Group B fluvastatin significantly reduced the level of TC (from 7.22 +/- 0.88 to 5.99 +/- 0.98 mM/L), of LDL-C (from 5.13 +/- 0.71 to 3.95 +/- 0.88 mM/L), and the level of ApoB (from 0.97 +/- 0.26 to 0.85 +/- 0.15 mM/L), but did not influence significantly the level of HDL-C, ApoA1 and TG.
Neg (not) Regulation (influence) of ApoA1 associated with disorder of lipid metabolism
7) Confidence 0.07 Published 1996 Journal Orv Hetil Section Abstract Doc Link 8927338 Disease Relevance 0.88 Pain Relevance 0.08
Other human studies of vitreous have identified additional targets for investigation including Complement proteins [18], acute phase proteins [19], Apolipoprotein A1 [20], and interphotoreceptor retinoid-binding protein [21].
Spec (investigation) Regulation (targets) of Apolipoprotein A1 associated with disorder of lipid metabolism
8) Confidence 0.04 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 1.01 Pain Relevance 0.08
In the T-treated group apolipoprotein-A1 (Apo-A1) (treated 99.2 +/- 12 vs controls 116.2 +/- 27.7 g/l, P < 0.01) and high density lipoprotein cholesterol (HDL-C) (treated 1.3 +/- 0.3 vs controls 1.5 +/- 0.4 nmol/l, P < 0.01) were significantly decreased.
Regulation (controls) of apolipoprotein-A1
9) Confidence 0.03 Published 1998 Journal Clin. Endocrinol. (Oxf) Section Body Doc Link 9828903 Disease Relevance 0 Pain Relevance 0
Adjustment for age, body mass index, smoking, alcohol consumption, stress and tension at work, shift work, noise exposure and educational level in multiple linear regression analysis showed significant effects of the CS2 index on systolic BP, diastolic BP, cholesterol, HDL-cholesterol, LDL-cholesterol, apolipoprotein A1, apolipoprotein B, the LDL cholesterol/apolipoprotein B and HDL cholesterol/apolipoprotein A1 ratios; there were no significant effects on the triglycerides.
Regulation (effects) of apolipoprotein A1 in body associated with stress, nicotine addiction, obesity, disorder of lipid metabolism and alcohol
10) Confidence 0.02 Published 1992 Journal Int J Epidemiol Section Abstract Doc Link 1521980 Disease Relevance 1.55 Pain Relevance 0.21
Adjustment for age, body mass index, smoking, alcohol consumption, stress and tension at work, shift work, noise exposure and educational level in multiple linear regression analysis showed significant effects of the CS2 index on systolic BP, diastolic BP, cholesterol, HDL-cholesterol, LDL-cholesterol, apolipoprotein A1, apolipoprotein B, the LDL cholesterol/apolipoprotein B and HDL cholesterol/apolipoprotein A1 ratios; there were no significant effects on the triglycerides.
Regulation (effects) of apolipoprotein A1 in body associated with stress, nicotine addiction, obesity, disorder of lipid metabolism and alcohol
11) Confidence 0.01 Published 1992 Journal Int J Epidemiol Section Abstract Doc Link 1521980 Disease Relevance 1.56 Pain Relevance 0.21
Total cholesterol, triglycerides, high-density lipoprotein, apolipoprotein A1, apolipoprotein B, albumin, prealbumin, fibrinogen, troponin-T, and high-sensitivity C-reactive protein levels were not changed.
Neg (not) Regulation (changed) of apolipoprotein A1 associated with disorder of lipid metabolism
12) Confidence 0.01 Published 2009 Journal Perit Dial Int Section Abstract Doc Link 19293355 Disease Relevance 1.02 Pain Relevance 0.18

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