INT108308

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Context Info
Confidence 0.77
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 1.65
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ENOX1) extracellular space (ENOX1) oxidoreductase activity (ENOX1)
extracellular region (ENOX1) plasma membrane (ENOX1)
Anatomy Link Frequency
plasma 1
vesicle 1
ENOX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 12 99.32 Very High Very High Very High
Inflammation 14 92.40 High High
rheumatoid arthritis 2 50.00 Quite Low
dexamethasone 1 49.12 Quite Low
Pain 33 36.24 Quite Low
Arthritis 6 5.00 Very Low Very Low Very Low
spinal inflammation 2 5.00 Very Low Very Low Very Low
Crohn's disease 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Sciatica 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 75 99.56 Very High Very High Very High
Cancer 12 96.08 Very High Very High Very High
Alzheimer's Dementia 13 95.36 Very High Very High Very High
Carcinoma 1 62.08 Quite High
Pain 33 36.24 Quite Low
INFLAMMATION 14 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low
Seronegative Spondarthritis 4 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we report the cloning, expression, and characterization of a human candidate constitutive ENOX (CNOX or ENOX1) protein.
Gene_expression (expression) of ENOX1
1) Confidence 0.77 Published 2008 Journal Biochemistry Section Abstract Doc Link 19055324 Disease Relevance 0.09 Pain Relevance 0.06
Here we report the cloning, expression, and characterization of a human candidate constitutive ENOX (CNOX or ENOX1) protein.
Gene_expression (expression) of ENOX
2) Confidence 0.67 Published 2008 Journal Biochemistry Section Abstract Doc Link 19055324 Disease Relevance 0.08 Pain Relevance 0.06
Here we report the cloning, expression, and characterization of a human candidate constitutive ENOX (CNOX or ENOX1) protein.
Gene_expression (expression) of CNOX
3) Confidence 0.67 Published 2008 Journal Biochemistry Section Abstract Doc Link 19055324 Disease Relevance 0.09 Pain Relevance 0.06
CNOX proteins are widely distributed and exhibit oscillations in enzymatic activity with a period length of 24 min. tNOX proteins are cancer specific and exhibit oscillations with a period length of about 22 min.
Gene_expression (distributed) of CNOX associated with cancer
4) Confidence 0.65 Published 2003 Journal Cancer Lett. Section Abstract Doc Link 12565167 Disease Relevance 0.49 Pain Relevance 0
We found that Ecto-NOX1 expression is modulated by capsaicin: Indeed, it is positively regulated through a mechanism requiring binding of capsaicin to its receptor, namely the transient receptor potential vanilloid subtype 1 (TRPV1).
Gene_expression (expression) of Ecto-NOX1 associated with qutenza
5) Confidence 0.55 Published 2010 Journal Mol. Membr. Biol. Section Abstract Doc Link 20462348 Disease Relevance 0 Pain Relevance 0.23
Ligand-receptor interaction triggers a signalling cascade leading to ROS production, which in turn enhances expression and activity of Ecto-NOX1.
Gene_expression (expression) of Ecto-NOX1
6) Confidence 0.55 Published 2010 Journal Mol. Membr. Biol. Section Abstract Doc Link 20462348 Disease Relevance 0 Pain Relevance 0.23
Kinematic and EMG data were time normalized to 100 points for each stride and data were averaged across the ten minutes for each condition (i.e. ten strides per ten minutes of data = average of 100 strides per condition).


Gene_expression (normalized) of time
7) Confidence 0.07 Published 2010 Journal J Foot Ankle Res Section Body Doc Link PMC2851667 Disease Relevance 0 Pain Relevance 0
A recombinant ECTO-NOX (tNOX) and a recombinant plasma membrane associated AAA-ATPase (ATPase Associated with Different Cellular Activities) were combined in stoichiometric proportions into liposomes together with albumin as a source of protein thiols.
Gene_expression (source) of recombinant ECTO-NOX in plasma
8) Confidence 0.04 Published 2006 Journal Biofactors Section Abstract Doc Link 17379941 Disease Relevance 0 Pain Relevance 0
With the lipid vesicle systems, the recombinant ECTO-NOX, the recombinant AAA-ATPase, a source of protein thiols and ATP all were required.
Gene_expression (source) of recombinant ECTO-NOX in vesicle
9) Confidence 0.04 Published 2006 Journal Biofactors Section Abstract Doc Link 17379941 Disease Relevance 0 Pain Relevance 0.10
Expression

levels of the house-keeping gene (GAPDH) were similar in all patients.


Gene_expression (Expression) of house-keeping gene
10) Confidence 0.01 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17807 Disease Relevance 0.91 Pain Relevance 0

General Comments

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