INT10832

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Context Info
Confidence 0.78
First Reported 1992
Last Reported 2011
Negated 13
Speculated 21
Reported most in Body
Documents 1050
Total Number 1079
Disease Relevance 698.72
Pain Relevance 270.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL8) extracellular space (IL8) extracellular region (IL8)
intracellular (IL8)
Anatomy Link Frequency
neutrophils 47
monocyte 44
fibroblasts 32
macrophage 29
epithelial cells 24
IL8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 18690 100.00 Very High Very High Very High
cytokine 14231 100.00 Very High Very High Very High
chemokine 7181 100.00 Very High Very High Very High
metalloproteinase 2305 100.00 Very High Very High Very High
Inflammatory response 1584 100.00 Very High Very High Very High
antagonist 1513 100.00 Very High Very High Very High
Inflammatory mediators 1332 100.00 Very High Very High Very High
psoriasis 650 100.00 Very High Very High Very High
substance P 368 100.00 Very High Very High Very High
Chronic pancreatitis 375 99.90 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 21169 100.00 Very High Very High Very High
Cancer 9586 100.00 Very High Very High Very High
Rheumatoid Arthritis 5565 100.00 Very High Very High Very High
Pulmonary Disease 4846 100.00 Very High Very High Very High
Eye Disease 2291 100.00 Very High Very High Very High
Adhesions 1877 100.00 Very High Very High Very High
Necrosis 1072 100.00 Very High Very High Very High
Dengue 996 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 984 100.00 Very High Very High Very High
Sepsis 879 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We investigated the effect of anesthetics on isolated human polymorphonuclear leukocyte production of IL-8.
Gene_expression (production) of IL-8 in polymorphonuclear leukocyte
1) Confidence 0.78 Published 1998 Journal Anesth. Analg. Section Abstract Doc Link 9620522 Disease Relevance 0.09 Pain Relevance 0.10
Detectable levels of IL-8 and nitrite/nitrate were found in 24 and 19 of 27 PE-samples, respectively.
Gene_expression (levels) of IL-8
2) Confidence 0.78 Published 2001 Journal J Endod Section Abstract Doc Link 11771582 Disease Relevance 0.38 Pain Relevance 0.23
Production of interleukin-8 and nitric oxide in human periapical lesions.
Gene_expression (Production) of interleukin-8
3) Confidence 0.78 Published 2001 Journal J Endod Section Title Doc Link 11771582 Disease Relevance 0.44 Pain Relevance 0.23
RESULTS: No IL-8 was detected in the samples from normal pulp, but significant amount of IL-8 appeared in inflamed pulp tissues, and the level of IL-8 in exudates of acute stage of pulpitis was higher than that of chronic stage (P < 0.01).
Gene_expression (detected) of IL-8
4) Confidence 0.78 Published 2000 Journal Chin J Dent Res Section Body Doc Link 11314344 Disease Relevance 0.09 Pain Relevance 0
Detection of interleukin-8 in exudates from normal and inflamed human dental pulp tissues.
Gene_expression (Detection) of interleukin-8 in dental pulp
5) Confidence 0.78 Published 2000 Journal Chin J Dent Res Section Title Doc Link 11314344 Disease Relevance 0 Pain Relevance 0.09
CONCLUSIONS: This study demonstrates that IL-8 is produced and accumulated in pulp inflammation and may play a role in the occurrence and development of human pulpitis.


Gene_expression (produced) of IL-8
6) Confidence 0.78 Published 2000 Journal Chin J Dent Res Section Body Doc Link 11314344 Disease Relevance 0.08 Pain Relevance 0
Thus, several other photochemical products, besides O3, could have significant effects on IL-8 production in human lung cells.
Gene_expression (production) of IL-8 in lung
7) Confidence 0.78 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
Figure 5A shows that ISO photochemical products induced a greater change in IL-8 expression (IL-8 protein induced) compared with clean air control.
Gene_expression (expression) of IL-8
8) Confidence 0.78 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
Directly comparing the effects of photochemical products using A549 cells from either ISO or BD on IL-8 expression suggests that the products generated from ISO have a greater effect on IL-8 expression than do BD photochemical products (Figure 5C), although these data were not statistically significant (p = 0.06).
Gene_expression (expression) of IL-8 in A549
9) Confidence 0.78 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
Although exposure to ISO and BD photochemical products generated significant levels of cytotoxicity and IL-8 expression in A549 cells, no significant effects were observed in differentiated human bronchial epithelial cells.
Gene_expression (expression) of IL-8 in epithelial cells
10) Confidence 0.78 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
The IL-8 mRNA and protein data indicate that both biogenic ISO and anthropogenic BD, as they react within the atmosphere, generate products that are more potent inducers of IL-8 gene expression than the unreacted volatile organic compounds.
Gene_expression (expression) of IL-8
11) Confidence 0.78 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
In contrast, ISO plus NO alone had no significant effect on IL-8 expression.
Gene_expression (expression) of IL-8
12) Confidence 0.78 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
In this study, we examined cytotoxicity and IL-8 gene expression induced by these photochemical gaseous mixtures using A549 cells, a human alveolar type II-like cell line, and differentiated human bronchial cells.
Gene_expression (expression) of IL-8 in A549
13) Confidence 0.78 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
Figure 5A shows that ISO photochemical products induced a greater change in IL-8 expression (IL-8 protein induced) compared with clean air control.
Gene_expression (expression) of IL-8
14) Confidence 0.78 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
The data presented here demonstrate that ISO and BD photochemical products increased LDH release as well as IL-8 expression compared with their clean air controls.
Gene_expression (expression) of IL-8
15) Confidence 0.78 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
Hence, if IL-8 production was solely based on O3 concentrations, the photochemical products of BD would produce a greater IL-8 response than would those of ISO.
Gene_expression (production) of IL-8
16) Confidence 0.78 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
Directly comparing the effects of photochemical products using A549 cells from either ISO or BD on IL-8 expression suggests that the products generated from ISO have a greater effect on IL-8 expression than do BD photochemical products (Figure 5C), although these data were not statistically significant (p = 0.06).
Gene_expression (expression) of IL-8 in A549
17) Confidence 0.78 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
Because this is not the case, these data indicate that O3 is not the sole inducer of IL-8 protein secretion, but that other photochemical products generated during the reactions of ISO or BD with sunlight are causing the increase in IL-8 production.
Gene_expression (production) of IL-8
18) Confidence 0.78 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
Figure 5B demonstrates that BD photochemical products induced a significantly greater IL-8 expression compared with BD plus NO alone, which also enhanced IL-8 expression compared with the clean air control.
Gene_expression (expression) of IL-8
19) Confidence 0.78 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
Data derived from these experiments could suggest potential agents in both the ISO and BD experiments that enhanced IL-8 production.
Gene_expression (production) of IL-8
20) Confidence 0.78 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0

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