INT108325

Context Info Confidence 0.39 First Reported 2003 Last Reported 2010 Negated 1 Speculated 1 Reported most in Body Documents 26 Total Number 39 Disease Relevance 48.33 Pain Relevance 1.39

cell differentiation (Scrib) cell proliferation (Scrib) plasma membrane (Scrib) cytoplasm (Scrib)

Anatomy Link Frequency liver 6 blood 1 colon 1 bands 1 bowel 1 Scrib (Mus musculus)

Pain Link Frequency Relevance Heat Crohn's disease 15 99.80 Inflammation 182 98.92 palliative 15 98.84 agonist 38 97.84 COX-2 inhibitor 55 92.00 cINOD 41 90.76 antagonist 7 74.60 cytokine 33 74.24 metalloproteinase 42 69.92 Inflammatory response 2 64.40

Disease Link Frequency Relevance Heat Colorectal Cancer 1613 100.00 Colon Cancer 1206 100.00 Metastasis 792 100.00 Skin Cancer 7 99.84 Disease 240 99.80 Inflammatory Bowel Disease 96 99.52 Cancer 1953 99.46 Hypoxia 12 99.08 INFLAMMATION 179 98.92 Injury 23 98.60

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

PATIENTS AND METHODS: DCC protein expression was assessed immunohistochemically on archival specimens of CRC metastases from 42 patients homogeneously treated by methotrexate-modulated bolus FU alternated to 6-S-leucovorin-modulated infused FU and was retrospectively correlated with patient characteristics and clinical outcome.

Gene_expression (expression) of CRC

1) Confidence 0.39 Published 2004 Journal J. Clin. Oncol. Section Body Doc Link 15365072 Disease Relevance 0.28 Pain Relevance 0

These studies in mice also provide important information that supports the benefit of COX-2 inhibition, not only in the prevention of CRC, but also potentially in the treatment of this common malignancy.

Neg (prevention) Gene_expression (prevention) of CRC associated with malignant neoplastic disease and colon cancer

2) Confidence 0.35 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12566300 Disease Relevance 0.63 Pain Relevance 0.08

PURPOSE: To determine whether deleted in colon cancer (DCC) protein expression in colorectal cancer (CRC) metastases could predict outcome to palliative fluorouracil (FU)-based chemotherapy and to assess whether it is similar to that observed in the corresponding primary tumors.

Gene_expression (expression) of CRC in colon associated with cancer, colon cancer, metastasis and palliative

3) Confidence 0.31 Published 2004 Journal J. Clin. Oncol. Section Abstract Doc Link 15365072 Disease Relevance 0.69 Pain Relevance 0.17

However, the ontogeny of RAS expression during CRC liver metastases progression has not been described, nor have the effects of captopril treatment on RAS expression in tumors been documented.

Gene_expression (progression) of CRC in liver associated with cancer, colon cancer and metastasis

4) Confidence 0.30 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.53 Pain Relevance 0

However, its expression during the development of CRC liver metastases has not been examined.

Gene_expression (expression) of CRC in liver associated with colon cancer and metastasis

5) Confidence 0.30 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.28 Pain Relevance 0.06

However, our immunohistochemical analysis suggests that at least some of the expression of ACE in CRC metastases is derived from infiltrating cells.

Gene_expression (expression) of CRC associated with colon cancer and metastasis

6) Confidence 0.30 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.64 Pain Relevance 0

ACE and ACE2 expression in CRC liver metastases

Gene_expression (liver) of CRC in liver associated with colon cancer and metastasis

7) Confidence 0.30 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 2.35 Pain Relevance 0

Angiotensinogen expression in CRC metastases was unchanged by captopril treatment, with no significant difference between control and captopril treated CRC metastases at either day 16 or day 21.

Gene_expression (expression) of CRC associated with colon cancer and metastasis

8) Confidence 0.30 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 2.05 Pain Relevance 0

Angiotensinogen expression is lower in CRC liver metastases and is reduced in the liver surrounding tumors following captopril treatment

Gene_expression (metastases) of CRC in liver associated with cancer, colon cancer and metastasis

9) Confidence 0.30 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 2.17 Pain Relevance 0

Early detection of CRC reduces CRC-related mortality; early detection and removal of its precursor lesions -adenomas- reduces both the incidence and mortality of CRC[4].

Gene_expression (detection) of CRC associated with adenoma and colorectal cancer

10) Confidence 0.29 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2889851 Disease Relevance 1.25 Pain Relevance 0

Early detection of CRC reduces CRC-related mortality; early detection and removal of its precursor lesions -adenomas- reduces both the incidence and mortality of CRC[4].

Gene_expression (reduces) of CRC associated with adenoma and colorectal cancer

11) Confidence 0.29 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2889851 Disease Relevance 1.25 Pain Relevance 0

Captopril treatment reduced CRC metastases ACE expression during the period of rapid growth, but ACE expression increased at late stages (day 21).

Gene_expression (expression) of CRC associated with colon cancer and metastasis

12) Confidence 0.27 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.41 Pain Relevance 0

Captopril inhibits CRC liver metastases

Gene_expression (metastases) of CRC in liver associated with colon cancer and metastasis

13) Confidence 0.26 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.13 Pain Relevance 0

Several components of the RAS are expressed in primary CRC and we have shown previously that blockade of the RAS decreased tumor growth in a mouse model of CRC liver metastases [8,19].

Gene_expression (expressed) of CRC in liver associated with cancer, colon cancer and metastasis

14) Confidence 0.26 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.34 Pain Relevance 0

Early detection and removal of CRC or its precursor lesions by population screening can reduce mortality.

Gene_expression (detection) of CRC associated with colorectal cancer

15) Confidence 0.25 Published 2010 Journal BMC Gastroenterol Section Abstract Doc Link PMC2889851 Disease Relevance 0.47 Pain Relevance 0

causes inhibition of tumor cell growth in cell lines derived from CRC,

Gene_expression (derived) of CRC associated with colorectal cancer and cancer

16) Confidence 0.09 Published 2008 Journal PPAR Research Section Body Doc Link PMC2422873 Disease Relevance 1.80 Pain Relevance 0.20

MUTYH associated polyposis is a frequent inherited CRC predisposition, which can be mostly in a recessive form of inheritance (bi-allelic or compound mutations) but also as a dominant component, and therefore DNA screening of the MUTYH gene should look for both heterozygous and homozygous mutations [46].

Gene_expression (predisposition) of CRC associated with colon cancer

17) Confidence 0.07 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2772987 Disease Relevance 1.22 Pain Relevance 0

modulatory activities that aid in CRC chemoprevention by suppressing

Gene_expression (chemoprevention) of CRC associated with colon cancer

18) Confidence 0.06 Published 2009 Journal PPAR Research Section Body Doc Link PMC2672162 Disease Relevance 1.59 Pain Relevance 0.19

The risk of developing CRC for CD and UC

Gene_expression (developing) of CRC associated with inflammatory bowel disease, crohn's disease and colon cancer

19) Confidence 0.06 Published 2009 Journal PPAR Research Section Body Doc Link PMC2672162 Disease Relevance 1.79 Pain Relevance 0.30

Several non-invasive tests for detecting CRC are available, of which the fecal occult blood test (FOBT) is the most commonly used [6,7].

Gene_expression (detecting) of CRC in blood associated with colorectal cancer

20) Confidence 0.06 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956090 Disease Relevance 0.86 Pain Relevance 0

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