INT108325

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Context Info
Confidence 0.39
First Reported 2003
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 26
Total Number 39
Disease Relevance 48.33
Pain Relevance 1.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Scrib) cell proliferation (Scrib) plasma membrane (Scrib)
cytoplasm (Scrib)
Anatomy Link Frequency
liver 6
blood 1
colon 1
bands 1
bowel 1
Scrib (Mus musculus)
Pain Link Frequency Relevance Heat
Crohn's disease 15 99.80 Very High Very High Very High
Inflammation 182 98.92 Very High Very High Very High
palliative 15 98.84 Very High Very High Very High
agonist 38 97.84 Very High Very High Very High
COX-2 inhibitor 55 92.00 High High
cINOD 41 90.76 High High
antagonist 7 74.60 Quite High
cytokine 33 74.24 Quite High
metalloproteinase 42 69.92 Quite High
Inflammatory response 2 64.40 Quite High
Disease Link Frequency Relevance Heat
Colorectal Cancer 1613 100.00 Very High Very High Very High
Colon Cancer 1206 100.00 Very High Very High Very High
Metastasis 792 100.00 Very High Very High Very High
Skin Cancer 7 99.84 Very High Very High Very High
Disease 240 99.80 Very High Very High Very High
Inflammatory Bowel Disease 96 99.52 Very High Very High Very High
Cancer 1953 99.46 Very High Very High Very High
Hypoxia 12 99.08 Very High Very High Very High
INFLAMMATION 179 98.92 Very High Very High Very High
Injury 23 98.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PATIENTS AND METHODS: DCC protein expression was assessed immunohistochemically on archival specimens of CRC metastases from 42 patients homogeneously treated by methotrexate-modulated bolus FU alternated to 6-S-leucovorin-modulated infused FU and was retrospectively correlated with patient characteristics and clinical outcome.
Gene_expression (expression) of CRC
1) Confidence 0.39 Published 2004 Journal J. Clin. Oncol. Section Body Doc Link 15365072 Disease Relevance 0.28 Pain Relevance 0
These studies in mice also provide important information that supports the benefit of COX-2 inhibition, not only in the prevention of CRC, but also potentially in the treatment of this common malignancy.
Neg (prevention) Gene_expression (prevention) of CRC associated with malignant neoplastic disease and colon cancer
2) Confidence 0.35 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12566300 Disease Relevance 0.63 Pain Relevance 0.08
PURPOSE: To determine whether deleted in colon cancer (DCC) protein expression in colorectal cancer (CRC) metastases could predict outcome to palliative fluorouracil (FU)-based chemotherapy and to assess whether it is similar to that observed in the corresponding primary tumors.
Gene_expression (expression) of CRC in colon associated with cancer, colon cancer, metastasis and palliative
3) Confidence 0.31 Published 2004 Journal J. Clin. Oncol. Section Abstract Doc Link 15365072 Disease Relevance 0.69 Pain Relevance 0.17
However, the ontogeny of RAS expression during CRC liver metastases progression has not been described, nor have the effects of captopril treatment on RAS expression in tumors been documented.
Gene_expression (progression) of CRC in liver associated with cancer, colon cancer and metastasis
4) Confidence 0.30 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.53 Pain Relevance 0
However, its expression during the development of CRC liver metastases has not been examined.
Gene_expression (expression) of CRC in liver associated with colon cancer and metastasis
5) Confidence 0.30 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.28 Pain Relevance 0.06
However, our immunohistochemical analysis suggests that at least some of the expression of ACE in CRC metastases is derived from infiltrating cells.
Gene_expression (expression) of CRC associated with colon cancer and metastasis
6) Confidence 0.30 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.64 Pain Relevance 0
ACE and ACE2 expression in CRC liver metastases
Gene_expression (liver) of CRC in liver associated with colon cancer and metastasis
7) Confidence 0.30 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 2.35 Pain Relevance 0
Angiotensinogen expression in CRC metastases was unchanged by captopril treatment, with no significant difference between control and captopril treated CRC metastases at either day 16 or day 21.
Gene_expression (expression) of CRC associated with colon cancer and metastasis
8) Confidence 0.30 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 2.05 Pain Relevance 0
Angiotensinogen expression is lower in CRC liver metastases and is reduced in the liver surrounding tumors following captopril treatment
Gene_expression (metastases) of CRC in liver associated with cancer, colon cancer and metastasis
9) Confidence 0.30 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 2.17 Pain Relevance 0
Early detection of CRC reduces CRC-related mortality; early detection and removal of its precursor lesions -adenomas- reduces both the incidence and mortality of CRC[4].
Gene_expression (detection) of CRC associated with adenoma and colorectal cancer
10) Confidence 0.29 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2889851 Disease Relevance 1.25 Pain Relevance 0
Early detection of CRC reduces CRC-related mortality; early detection and removal of its precursor lesions -adenomas- reduces both the incidence and mortality of CRC[4].
Gene_expression (reduces) of CRC associated with adenoma and colorectal cancer
11) Confidence 0.29 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2889851 Disease Relevance 1.25 Pain Relevance 0
Captopril treatment reduced CRC metastases ACE expression during the period of rapid growth, but ACE expression increased at late stages (day 21).
Gene_expression (expression) of CRC associated with colon cancer and metastasis
12) Confidence 0.27 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.41 Pain Relevance 0
Captopril inhibits CRC liver metastases
Gene_expression (metastases) of CRC in liver associated with colon cancer and metastasis
13) Confidence 0.26 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.13 Pain Relevance 0
Several components of the RAS are expressed in primary CRC and we have shown previously that blockade of the RAS decreased tumor growth in a mouse model of CRC liver metastases [8,19].
Gene_expression (expressed) of CRC in liver associated with cancer, colon cancer and metastasis
14) Confidence 0.26 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.34 Pain Relevance 0
Early detection and removal of CRC or its precursor lesions by population screening can reduce mortality.
Gene_expression (detection) of CRC associated with colorectal cancer
15) Confidence 0.25 Published 2010 Journal BMC Gastroenterol Section Abstract Doc Link PMC2889851 Disease Relevance 0.47 Pain Relevance 0
causes inhibition of tumor cell growth in cell lines derived from CRC,
Gene_expression (derived) of CRC associated with colorectal cancer and cancer
16) Confidence 0.09 Published 2008 Journal PPAR Research Section Body Doc Link PMC2422873 Disease Relevance 1.80 Pain Relevance 0.20
MUTYH associated polyposis is a frequent inherited CRC predisposition, which can be mostly in a recessive form of inheritance (bi-allelic or compound mutations) but also as a dominant component, and therefore DNA screening of the MUTYH gene should look for both heterozygous and homozygous mutations [46].
Gene_expression (predisposition) of CRC associated with colon cancer
17) Confidence 0.07 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2772987 Disease Relevance 1.22 Pain Relevance 0
modulatory activities that aid in CRC chemoprevention by suppressing
Gene_expression (chemoprevention) of CRC associated with colon cancer
18) Confidence 0.06 Published 2009 Journal PPAR Research Section Body Doc Link PMC2672162 Disease Relevance 1.59 Pain Relevance 0.19
The risk of developing CRC for CD and UC
Gene_expression (developing) of CRC associated with inflammatory bowel disease, crohn's disease and colon cancer
19) Confidence 0.06 Published 2009 Journal PPAR Research Section Body Doc Link PMC2672162 Disease Relevance 1.79 Pain Relevance 0.30
Several non-invasive tests for detecting CRC are available, of which the fecal occult blood test (FOBT) is the most commonly used [6,7].
Gene_expression (detecting) of CRC in blood associated with colorectal cancer
20) Confidence 0.06 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956090 Disease Relevance 0.86 Pain Relevance 0

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