INT108326

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Context Info
Confidence 0.26
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 9.02
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Scrib) cell proliferation (Scrib) plasma membrane (Scrib)
cytoplasm (Scrib)
Anatomy Link Frequency
liver 2
Scrib (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 22 97.84 Very High Very High Very High
COX-2 inhibitor 1 89.92 High High
antagonist 2 74.60 Quite High
Inflammation 10 67.80 Quite High
cytokine 3 53.16 Quite High
metalloproteinase 11 51.60 Quite High
cINOD 10 25.00 Low Low
cOX1 1 25.00 Low Low
COX2 1 25.00 Low Low
cryotherapy 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colorectal Cancer 310 100.00 Very High Very High Very High
Colon Cancer 141 100.00 Very High Very High Very High
Metastasis 113 100.00 Very High Very High Very High
Skin Cancer 2 99.84 Very High Very High Very High
Cancer 340 99.64 Very High Very High Very High
Disease 41 98.40 Very High Very High Very High
Brain Tumor 1 98.24 Very High Very High Very High
Malignant Neoplastic Disease 15 97.80 Very High Very High Very High
Death 9 83.36 Quite High
Recurrence 4 72.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These studies in mice also provide important information that supports the benefit of COX-2 inhibition, not only in the prevention of CRC, but also potentially in the treatment of this common malignancy.
Positive_regulation (supports) of Neg (prevention) Gene_expression (prevention) of CRC associated with malignant neoplastic disease and colon cancer
1) Confidence 0.26 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12566300 Disease Relevance 0.64 Pain Relevance 0.10
ACE and ACE2 expression in CRC liver metastases
Positive_regulation (liver) of Gene_expression (liver) of CRC in liver associated with colon cancer and metastasis
2) Confidence 0.22 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 2.35 Pain Relevance 0
causes inhibition of tumor cell growth in cell lines derived from CRC,
Positive_regulation (derived) of Gene_expression (derived) of CRC associated with colorectal cancer and cancer
3) Confidence 0.07 Published 2008 Journal PPAR Research Section Body Doc Link PMC2422873 Disease Relevance 1.80 Pain Relevance 0.20
One of the key requirements of biomarkers for detecting CRC is that it must allow detection of the disease at earlier stages.
Positive_regulation (requirements) of Gene_expression (detecting) of CRC associated with colorectal cancer and disease
4) Confidence 0.04 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956090 Disease Relevance 1.59 Pain Relevance 0
By analyzing the secretomes of 21 cancer cell lines derived from 12 cancer types, collapsin response mediator protein-2 (CRMP-2) was identified to be a potential CRC biomarker in the serums of 201 CRC patients and 210 healthy controls [42].
Positive_regulation (response) of Gene_expression (biomarker) of CRC associated with colorectal cancer and cancer
5) Confidence 0.04 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956090 Disease Relevance 1.07 Pain Relevance 0.03
By analyzing the secretomes of 21 cancer cell lines derived from 12 cancer types, collapsin response mediator protein-2 (CRMP-2) was identified to be a potential CRC biomarker in the serums of 201 CRC patients and 210 healthy controls [42].
Positive_regulation (potential) of Gene_expression (biomarker) of CRC associated with colorectal cancer and cancer
6) Confidence 0.04 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956090 Disease Relevance 1.04 Pain Relevance 0.03
99mTc-MAA uptake by CRC hepatic metastases
Positive_regulation (uptake) of Gene_expression (metastases) of CRC associated with colon cancer and metastasis
7) Confidence 0.03 Published 2005 Journal BMC Nucl Med Section Body Doc Link PMC1360059 Disease Relevance 0.53 Pain Relevance 0

General Comments

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