INT108327

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Context Info
Confidence 0.38
First Reported 2001
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 14.36
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ccnd1) intracellular (Ccnd1) enzyme binding (Ccnd1)
cell cycle (Ccnd1) cell division (Ccnd1) kinase activity (Ccnd1)
Anatomy Link Frequency
hepatocyte 2
endothelial cell 2
colon 2
M cell 2
Ccnd1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 13 100.00 Very High Very High Very High
metalloproteinase 3 98.68 Very High Very High Very High
cytokine 22 95.28 Very High Very High Very High
Inflammation 12 90.60 High High
fibrosis 4 86.32 High High
Dismenorea 3 84.88 Quite High
cINOD 29 62.84 Quite High
Chronic pancreatitis 1 56.48 Quite High
aspirin 15 50.00 Quite Low
Bile 14 50.00 Quite Low
Disease Link Frequency Relevance Heat
Cancer 563 100.00 Very High Very High Very High
Hepatotoxicity 5 100.00 Very High Very High Very High
Colon Cancer 131 99.84 Very High Very High Very High
Hepatocellular Cancer 89 99.22 Very High Very High Very High
Apoptosis 182 99.14 Very High Very High Very High
Reprotox - General 1 13 98.96 Very High Very High Very High
Disease 50 97.28 Very High Very High Very High
Hyperplasia 8 97.12 Very High Very High Very High
Klatskin's Tumor 28 95.96 Very High Very High Very High
Biliary Cancer 20 94.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also noted the re-expression of cyclin D1, which was down-regulated in the stable 199bSC1 clone.
Negative_regulation (down) of Gene_expression (expression) of cyclin D1
1) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2656623 Disease Relevance 0.25 Pain Relevance 0
Furthermore, these mice had a 24-hr lag in the hepatic expression of the G1/S checkpoint regulator genes cyclin D1 (Ccnd1) and c-myc and increased expression of the interleukin-1?
Negative_regulation (hepatic) of Gene_expression (expression) of cyclin D1
2) Confidence 0.38 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1570084 Disease Relevance 0.86 Pain Relevance 0.14
Furthermore, these mice had a 24-hr lag in the hepatic expression of the G1/S checkpoint regulator genes cyclin D1 (Ccnd1) and c-myc and increased expression of the interleukin-1?
Negative_regulation (hepatic) of Gene_expression (expression) of Ccnd1
3) Confidence 0.38 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1570084 Disease Relevance 0.86 Pain Relevance 0.14
We assessed the expression of p53, cyclin D1 and survivin, to compare the differences in molecular changes associated with the prognosis between BDC and GB cancer.
Negative_regulation (assessed) of Gene_expression (expression) of cyclin D1 associated with klatskin's tumor and cancer
4) Confidence 0.32 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2974735 Disease Relevance 2.17 Pain Relevance 0
In contrast, in TNFR1-/- mice, which exhibit exaggerated acetaminophen hepatotoxicity, hepatocyte proliferation, and expression of cyclin D1 and cyclin A, as well as the cyclin dependent kinases, Cdk4 and Cdk2, were reduced.
Negative_regulation (exhibit) of Gene_expression (expression) of cyclin D1 in hepatocyte associated with paracetamol and hepatotoxicity
5) Confidence 0.25 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14644624 Disease Relevance 0.58 Pain Relevance 0.56
Lumican significantly suppressed subcutaneous tumor formation in syngenic mice, with a concomitant decrease in cyclin D1 expression level, and induced and/or enhanced the apoptosis of these cells.
Negative_regulation (decrease) of Gene_expression (expression) of cyclin D1 associated with cancer and apoptosis
6) Confidence 0.25 Published 2005 Journal J Nippon Med Sch Section Abstract Doc Link 16046829 Disease Relevance 1.24 Pain Relevance 0.08
Biochemical analyses of the primary splenic tumor in rofecoxib-treated mice showed no alteration in COX-1 expression, but significant decreases in the expression of the tumor-promoting proteins COX-2, cyclin D1, cytosolic beta-catenin, matrix metalloproteinases-2 and -9, and vascular endothelial cell- derived growth factor.
Neg (no) Negative_regulation (decreases) of Gene_expression (expression) of cyclin D1 in endothelial cell associated with cancer and metalloproteinase
7) Confidence 0.24 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12566300 Disease Relevance 1.42 Pain Relevance 0.31
Furthermore, the expression of common markers of checkpoint/arrest involved in G1/S and S phase transition, such as Ccne, Ccnd, Gas1, and Dbf4, was also decreased.
Negative_regulation (decreased) of Gene_expression (expression) of Ccnd
8) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0 Pain Relevance 0
Therefore, we examined cyclin D1, E and A cdk2 activities in TM10 and TM2H cell cultures after 24 h treatment with SAHA because they reflect kinase activities before, during and after the G1 ?
Spec (examined) Negative_regulation (examined) of Gene_expression (activities) of cyclin D1
9) Confidence 0.16 Published 2001 Journal Breast Cancer Res Section Body Doc Link PMC13923 Disease Relevance 0.08 Pain Relevance 0
Anti-estrogen treatment is reported to be able to cause an acute decrease in c-Myc expression, a subsequent decline in cyclin D1 expression, and, ultimately, inhibition of DNA synthesis and arrest of cells in a quiescent state [29].
Negative_regulation (decline) of Gene_expression (expression) of cyclin D1
10) Confidence 0.12 Published 2009 Journal J Transl Med Section Body Doc Link PMC2742515 Disease Relevance 1.18 Pain Relevance 0.08
is activated by gossypol in prostate cancer cells, and gossypol upregulates p21 expression and downregulates cyclin D1 and Rb expression in colon cancer cells [8,9].
Negative_regulation (downregulates) of Gene_expression (expression) of cyclin D1 in colon associated with colon cancer and reprotox - general 1
11) Confidence 0.12 Published 2009 Journal J Transl Med Section Body Doc Link PMC2742515 Disease Relevance 1.18 Pain Relevance 0
Moreover, expression of p21 protein was upregulated as early as 24 h and gradually returned to low level at 72 h since most of the CNE-2 cells were dead at this time (Fig. 3B); unlike p21, expression of both cyclin D1 and cyclin E were downregulated following the degradation of c-Myc.
Negative_regulation (downregulated) of Gene_expression (expression) of cyclin D1
12) Confidence 0.12 Published 2009 Journal J Transl Med Section Body Doc Link PMC2742515 Disease Relevance 0.29 Pain Relevance 0
inhibition by TZDs was caused by the decrease of the expression of cyclin D1,
Negative_regulation (decrease) of Gene_expression (expression) of cyclin D1
13) Confidence 0.10 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 0.70 Pain Relevance 0
expression levels of c-myc, cyclin D1
Negative_regulation (levels) of Gene_expression (expression) of cyclin D1
14) Confidence 0.10 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 0.38 Pain Relevance 0
The blockage of EGFR and STAT3-signaling cascades seemingly increased the levels of p53, Bax and decreased levels of Bcl-xL, survivin, and cyclin D1 proteins.
Negative_regulation (decreased) of Gene_expression (levels) of cyclin D1
15) Confidence 0.07 Published 2008 Journal J Transl Med Section Body Doc Link PMC2267444 Disease Relevance 1.12 Pain Relevance 0
Moreover, depletion of PLD1 or 2 blocked expression of Wnt3a-induced target genes, including c-Myc, Cyclin D1, NOS2, and vimentin (Figure 5B).
Negative_regulation (depletion) of Gene_expression (expression) of Cyclin D1
16) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.06 Pain Relevance 0
Moreover, depletion of PLD1 or 2 blocked expression of Wnt3a-induced target genes, including c-Myc, Cyclin D1, NOS2, and vimentin (Figure 5B).
Negative_regulation (blocked) of Gene_expression (expression) of Cyclin D1
17) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.06 Pain Relevance 0
Depsipeptide has been shown to induce differentiation, cause G1 and G2/M cell cycle arrest and apoptosis, increase expression of p21 and cyclin E, decrease expression of cyclin D1 and c-myc, and cause hypophosphorylation of Rb (Sandor et al 2000; Picardo et al 2004; Piekarz et al 2004; Piekarz and Bates 2004).
Negative_regulation (decrease) of Gene_expression (expression) of cyclin D1 in M cell associated with apoptosis
18) Confidence 0.04 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721288 Disease Relevance 0.58 Pain Relevance 0
Therefore, we may infer that G1 to S arrest induced by knocking down CIAPIN1 in HCC cells was at least partly mediated by downregulation of cyclinD1 and upregulation p27 expression.


Negative_regulation (downregulation) of Gene_expression (expression) of cyclinD1 associated with hepatocellular cancer
19) Confidence 0.01 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.32 Pain Relevance 0

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