INT108328

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Context Info
Confidence 0.57
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.56
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CEL) extracellular space (CEL) small molecule metabolic process (CEL)
extracellular region (CEL) lipid metabolic process (CEL) cytoplasm (CEL)
Anatomy Link Frequency
endothelial cell 2
B-cell 2
CEL (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 1 100.00 Very High Very High Very High
cytokine 34 99.98 Very High Very High Very High
Inflammation 48 90.60 High High
cINOD 3 62.84 Quite High
Arthritis 28 58.60 Quite High
Bioavailability 13 52.52 Quite High
Bile 19 27.32 Quite Low
cOX1 1 25.00 Low Low
COX2 1 25.00 Low Low
COX-2 inhibitor 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Cancer 15 100.00 Very High Very High Very High
Bronchiectasis 70 96.28 Very High Very High Very High
INFLAMMATION 56 90.60 High High
Metastasis 2 88.92 High High
Hyperlipidemia 4 85.32 High High
Death 8 78.96 Quite High
Infection 13 76.88 Quite High
Colon Cancer 9 75.00 Quite High
Hypersensitivity 3 72.32 Quite High
Familial Adenomatous Polyposis 1 66.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Biochemical analyses of the primary splenic tumor in rofecoxib-treated mice showed no alteration in COX-1 expression, but significant decreases in the expression of the tumor-promoting proteins COX-2, cyclin D1, cytosolic beta-catenin, matrix metalloproteinases-2 and -9, and vascular endothelial cell- derived growth factor.
Neg (no) Negative_regulation (decreases) of Gene_expression (expression) of cell in endothelial cell associated with cancer and metalloproteinase
1) Confidence 0.57 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12566300 Disease Relevance 1.44 Pain Relevance 0.31
Compound 1 is a potent inhibitor of CEase (Kd = 25 nanomolar) and is highly selective for CEase compared to other serine hydrolases such as chymotrypsin [10].
Negative_regulation (inhibitor) of Gene_expression (selective) of CEase
2) Confidence 0.43 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC406500 Disease Relevance 0.09 Pain Relevance 0.03
Compound 1 is a potent inhibitor of CEase (Kd = 25 nanomolar) and is highly selective for CEase compared to other serine hydrolases such as chymotrypsin [10].
Negative_regulation (inhibitor) of Gene_expression (selective) of CEase
3) Confidence 0.43 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC406500 Disease Relevance 0.09 Pain Relevance 0.03
Comparison of HRCT scores and cytokine levels in BAL fluid
Negative_regulation (levels) of Gene_expression (fluid) of BAL associated with cytokine
4) Confidence 0.03 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1781448 Disease Relevance 0.52 Pain Relevance 0.23
A variety of polysaccharide polymers can be sulfated to produce potent inhibitors of human pancreatic cholesterol esterase.
Negative_regulation (inhibitors) of Gene_expression (produce) of pancreatic cholesterol esterase
5) Confidence 0.03 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2953395 Disease Relevance 0 Pain Relevance 0
The relative expression of macrophage markers and B-cell markers were decreased by exposure to the enzyme cocktail or to the rotation process, respectively.
Negative_regulation (decreased) of Gene_expression (expression) of cell in B-cell
6) Confidence 0.02 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875643 Disease Relevance 0.42 Pain Relevance 0.03

General Comments

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