INT108329

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.48
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 3.96
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (EGF, EPHB2) signal transduction (EGF) extracellular space (EGF)
extracellular region (EGF)
Anatomy Link Frequency
colon 4
EGF (Homo sapiens)
EPHB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 6 96.00 Very High Very High Very High
addiction 5 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 18 99.20 Very High Very High Very High
INFLAMMATION 6 95.76 Very High Very High Very High
Apoptosis 6 93.24 High High
Cancer 27 92.44 High High
Death 8 81.24 Quite High
Rectal Cancer 3 79.32 Quite High
Prostate Cancer 27 50.00 Quite Low
Targeted Disruption 12 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Metastasis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study we show that epidermal growth factor (EGF) strongly induces phosphorylation of ERK1/2 and Bad in HT29 colon cancer cells.
epidermal growth factor Positive_regulation (induces) of Phosphorylation (phosphorylation) of ERK in colon associated with colon cancer
1) Confidence 0.48 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12566304 Disease Relevance 1.39 Pain Relevance 0.17
Similarly, pretreatment with sulindac sulfide blocks the ability of EGF to induce ERK1/2 and Bad phosphorylation, but also down-regulates total Bad but not ERK1/2 protein levels.
EGF Positive_regulation (induce) of Phosphorylation (phosphorylation) of ERK
2) Confidence 0.48 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12566304 Disease Relevance 1.20 Pain Relevance 0.14
In this study we show that epidermal growth factor (EGF) strongly induces phosphorylation of ERK1/2 and Bad in HT29 colon cancer cells.
EGF Positive_regulation (induces) of Phosphorylation (phosphorylation) of ERK in colon associated with colon cancer
3) Confidence 0.48 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12566304 Disease Relevance 1.38 Pain Relevance 0.17
Growth factor dependent MAPK activation was constrained by dynamic measurements of phosphorylated ERK (ERKpp) levels following stimulation of EGFR with 8nM EGF (Fig. 5D).
EGF Positive_regulation (stimulation) of Phosphorylation (phosphorylated) of ERK
4) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox