INT10833

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Context Info
Confidence 0.62
First Reported 1992
Last Reported 2010
Negated 16
Speculated 9
Reported most in Body
Documents 68
Total Number 77
Disease Relevance 38.74
Pain Relevance 18.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL8) extracellular space (IL8) extracellular region (IL8)
intracellular (IL8)
Anatomy Link Frequency
neutrophil 10
cartilage 10
monocyte 6
mast cells 6
T lymphocytes 6
IL8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1243 100.00 Very High Very High Very High
cytokine 747 100.00 Very High Very High Very High
Osteoarthritis 498 100.00 Very High Very High Very High
antagonist 107 100.00 Very High Very High Very High
cINOD 51 100.00 Very High Very High Very High
Paracetamol 18 100.00 Very High Very High Very High
lidocaine 16 100.00 Very High Very High Very High
calcitonin gene related peptide 16 100.00 Very High Very High Very High
diclofenac 10 100.00 Very High Very High Very High
Inflammatory mediators 78 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1405 100.00 Very High Very High Very High
Osteoarthritis 512 100.00 Very High Very High Very High
Infection 209 100.00 Very High Very High Very High
Stress 175 100.00 Very High Very High Very High
Adhesions 154 100.00 Very High Very High Very High
Mucositis 60 100.00 Very High Very High Very High
Pulmonary Disease 905 99.84 Very High Very High Very High
Herpes Simplex Virus 240 99.84 Very High Very High Very High
Skin Cancer 19 99.84 Very High Very High Very High
Chronic Sinusitis 28 99.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, several other photochemical products, besides O3, could have significant effects on IL-8 production in human lung cells.
Regulation (effects) of Gene_expression (production) of IL-8 in lung
1) Confidence 0.62 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
Effect of tocolytics on interleukin-8 production by human amniotic and decidual cells.
Regulation (Effect) of Gene_expression (production) of interleukin-8
2) Confidence 0.62 Published 2006 Journal J. Reprod. Immunol. Section Title Doc Link 16384605 Disease Relevance 0.28 Pain Relevance 0.14
However, nifedipine and terbutaline did not significantly affect IL-8 production in either cell type.
Neg (not) Regulation (affect) of Gene_expression (production) of IL-8
3) Confidence 0.62 Published 2006 Journal J. Reprod. Immunol. Section Abstract Doc Link 16384605 Disease Relevance 0.19 Pain Relevance 0.10
Interestingly, IL-8 production can be controlled by the -251 A/T in the promoter region of this chemokine [23].
Regulation (controlled) of Gene_expression (production) of IL-8 associated with chemokine
4) Confidence 0.62 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 0.54 Pain Relevance 0.25
Amnion cell biosynthesis of interleukin-8: regulation by inflammatory cytokines.
Regulation (regulation) of Gene_expression (biosynthesis) of interleukin-8 in Amnion associated with inflammation and cytokine
5) Confidence 0.61 Published 1992 Journal J. Cell. Physiol. Section Title Doc Link 1522134 Disease Relevance 0.75 Pain Relevance 0.40
Effects of nimesulide and sodium diclofenac on interleukin-6, interleukin-8, proteoglycans and prostaglandin E2 production by human articular chondrocytes in vitro.
Regulation (Effects) of Gene_expression (production) of interleukin-8 in chondrocytes associated with diclofenac
6) Confidence 0.60 Published 1999 Journal Clin. Exp. Rheumatol. Section Title Doc Link 10342040 Disease Relevance 0.10 Pain Relevance 0.33
To demonstrate the effect of intracellular Ca(2+) on IL-8 production and related signaling, we stimulated human mast cell line HMC-1 with either calcium ionophore A23187 or thapsigargin.
Regulation (effect) of Gene_expression (production) of IL-8 in mast cell
7) Confidence 0.59 Published 2005 Journal Cytokine Section Abstract Doc Link 16343928 Disease Relevance 0.10 Pain Relevance 0.10
Furthermore, both nimesulide and diclofenac at therapeutic concentrations significantly decreased spontaneous and IL-1 beta-stimulated IL-6 production by human chondrocytes, but did not modify IL-8 production.
Neg (not) Regulation (modify) of Gene_expression (production) of IL-8 in chondrocytes
8) Confidence 0.54 Published 1999 Journal Clin. Exp. Rheumatol. Section Body Doc Link 10342040 Disease Relevance 0 Pain Relevance 0
No NSAID showed significant effects on basal and IL-1beta stimulated IL-8 production, except CELE and IBUP, which slightly increased basal IL-8 production.
Neg (except) Regulation (effects) of Gene_expression (production) of IL-8
9) Confidence 0.50 Published 2002 Journal J. Rheumatol. Section Body Doc Link 11950021 Disease Relevance 0 Pain Relevance 0
Since these effects have poorly been characterized in CRS, we examined the effects of ciprofloxacin on the IL-8 synthesis of HNECs stimulated with supernatants of S. aureus Newman.
Spec (examined) Regulation (effects) of Gene_expression (synthesis) of IL-8 associated with chronic sinusitis
10) Confidence 0.48 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2507710 Disease Relevance 0.78 Pain Relevance 0.13
Directly comparing the effects of photochemical products using A549 cells from either ISO or BD on IL-8 expression suggests that the products generated from ISO have a greater effect on IL-8 expression than do BD photochemical products (Figure 5C), although these data were not statistically significant (p = 0.06).
Regulation (effects) of Gene_expression (expression) of IL-8 in A549
11) Confidence 0.45 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
These results demonstrate that constitutive and induced NF-kappaB activation regulates IL-8 expression in melanoma cells.
Regulation (regulates) of Gene_expression (expression) of IL-8 associated with skin cancer
12) Confidence 0.42 Published 2002 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 12034025 Disease Relevance 0.68 Pain Relevance 0.39
Our data from the BALF show that all of the CXCL8 variants are rapidly transported from the alveolar spaces into the lung tissue, and CXCL8 levels are down to ?
Regulation (all) of Gene_expression (variants) of CXCL8 in lung
13) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909905 Disease Relevance 0.08 Pain Relevance 0.04
Effect of stress doses of hydrocortisone on S-100B vs. interleukin-8 and polymorphonuclear elastase levels in human septic shock.
Regulation (Effect) of Gene_expression (levels) of interleukin-8 associated with stress and sepsis
14) Confidence 0.40 Published 2005 Journal Clin. Chem. Lab. Med. Section Title Doc Link 15843228 Disease Relevance 1.05 Pain Relevance 0.13
The suppressive effect of amiloride on endotoxin-induced IL-8 production was associated with a decreased accumulation of IL-8 mRNA.
Regulation (effect) of Gene_expression (production) of IL-8
15) Confidence 0.40 Published 2002 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 12107048 Disease Relevance 0.46 Pain Relevance 0.35
OBJECTIVES: The aim of this study was to investigate the effects of two nonsteroidal anti-inflammatory drugs (NSAIDs), nimesulide and sodium diclofenac, on the production of proteoglycans (PG), prostaglandin E2 (PGE2) and cytokines (IL-6 and IL-8) by human articular chondrocytes in vitro.
Spec (investigate) Regulation (effects) of in PGE2 Gene_expression (production) of IL-8 in chondrocytes associated with inflammation, cinod, diclofenac and cytokine
16) Confidence 0.40 Published 1999 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 10342040 Disease Relevance 0.10 Pain Relevance 0.34
In macrophages, acetaminophen decreased the secretion of TNF-alpha (at 4 and 24 h, concentration-related) and IL-6 (at 24 h, at 0.1 mM), and did not affect significantly IL-8 production.
Neg (not) Regulation (affect) of Gene_expression (production) of IL-8 in macrophages associated with paracetamol
17) Confidence 0.36 Published 2005 Journal Int. J. Biochem. Cell Biol. Section Abstract Doc Link 15878691 Disease Relevance 0.22 Pain Relevance 0.73
In addition to IL-1b, other key inflammatory mediators, e.g., CXCL8 (IL-8), CCL2 (MCP-1) [42,49], and the synthesis of prostaglandins, by induction of COX-2 [49,50] are all up-regulated in response to withdrawal of P.
Regulation (regulated) of Gene_expression (synthesis) of CXCL8 associated with inflammatory mediators and withdrawal
18) Confidence 0.35 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775064 Disease Relevance 0.51 Pain Relevance 0.31
by human lung macrophages, without affecting the expression of IL-8 (de Boer 2005).
Neg (without) Regulation (affecting) of Gene_expression (expression) of IL-8 in macrophages
19) Confidence 0.35 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707155 Disease Relevance 0.60 Pain Relevance 0.13
We investigated the effects of lidocaine on activated human umbilical vein endothelial cell (HUVEC) interleukin (IL)-1beta, IL-6, and IL-8 concentrations and intercellular adhesion molecule-1 (ICAM-1) expression.
Spec (investigated) Regulation (effects) of Gene_expression (expression) of IL-8 in endothelial cell associated with lidocaine and adhesions
20) Confidence 0.33 Published 2005 Journal Anesth. Analg. Section Abstract Doc Link 15673867 Disease Relevance 0.46 Pain Relevance 0.42

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