INT108331

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Context Info
Confidence 0.49
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 5
Disease Relevance 6.72
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (BAD) cytoplasm (BAD) cytosol (BAD)
lipid binding (BAD) extracellular space (EGF) signal transduction (EGF)
Anatomy Link Frequency
colon 6
EGF (Homo sapiens)
BAD (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 10 96.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Colon Cancer 30 99.68 Very High Very High Very High
Cancer 25 96.84 Very High Very High Very High
Death 10 96.56 Very High Very High Very High
INFLAMMATION 10 95.76 Very High Very High Very High
Apoptosis 10 93.24 High High
Rectal Cancer 5 87.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study we show that epidermal growth factor (EGF) strongly induces phosphorylation of ERK1/2 and Bad in HT29 colon cancer cells.
EGF Positive_regulation (induces) of Phosphorylation (phosphorylation) of Bad in colon associated with colon cancer
1) Confidence 0.49 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12566304 Disease Relevance 1.38 Pain Relevance 0.17
In this study we show that epidermal growth factor (EGF) strongly induces phosphorylation of ERK1/2 and Bad in HT29 colon cancer cells.
epidermal growth factor Positive_regulation (induces) of Phosphorylation (phosphorylation) of Bad in colon associated with colon cancer
2) Confidence 0.49 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12566304 Disease Relevance 1.39 Pain Relevance 0.17
EGF-stimulated phosphorylation of ERK and Bad is blocked by pretreatment with U0126, a selective MAP kinase kinase (MKK)1/2 inhibitor.
EGF Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of Bad
3) Confidence 0.41 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12566304 Disease Relevance 1.33 Pain Relevance 0.16
Similarly, pretreatment with sulindac sulfide blocks the ability of EGF to induce ERK1/2 and Bad phosphorylation, but also down-regulates total Bad but not ERK1/2 protein levels.
EGF Positive_regulation (induce) of Phosphorylation (phosphorylation) of Bad
4) Confidence 0.41 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12566304 Disease Relevance 1.20 Pain Relevance 0.14
Sulindac sulfide inhibits epidermal growth factor-induced phosphorylation of extracellular-regulated kinase 1/2 and Bad in human colon cancer cells.
epidermal growth factor Positive_regulation (induced) of Phosphorylation (phosphorylation) of Bad in colon associated with colon cancer
5) Confidence 0.33 Published 2003 Journal Cancer Res. Section Title Doc Link 12566304 Disease Relevance 1.44 Pain Relevance 0.17

General Comments

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