INT108335

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Context Info
Confidence 0.80
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 7.30
Pain Relevance 2.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (EGF) extracellular space (EGF) extracellular region (EGF)
plasma membrane (EGF)
Anatomy Link Frequency
colon 1
MCF-7 1
tongue 1
EGF (Homo sapiens)
Pain Link Frequency Relevance Heat
lidocaine 34 99.42 Very High Very High Very High
opioid receptor 5 99.38 Very High Very High Very High
cytokine 63 95.36 Very High Very High Very High
Inflammation 52 94.52 High High
cINOD 64 93.60 High High
Kinase C 1 78.16 Quite High
Opioid 4 75.00 Quite High
Immobilon 5 73.68 Quite High
local anesthetic 1 70.32 Quite High
Cancer pain 1 56.16 Quite High
Disease Link Frequency Relevance Heat
Adhesions 4 100.00 Very High Very High Very High
Repression 1 99.92 Very High Very High Very High
Cancer 298 98.08 Very High Very High Very High
Colon Cancer 63 97.76 Very High Very High Very High
Tongue Neoplasms 3 97.36 Very High Very High Very High
Pancreatic Cancer 125 97.04 Very High Very High Very High
Apoptosis 120 96.36 Very High Very High Very High
Death 27 94.72 High High
INFLAMMATION 65 94.52 High High
Breast Cancer 80 94.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The outcome of our studies let us suggest that EGF-like ligands released by opioid receptor stimulation utilize different EGF receptors to phosphorylate ERKs, while EGF utilizes type 1 receptors.
Phosphorylation (phosphorylate) of EGF associated with opioid receptor
1) Confidence 0.80 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464054 Disease Relevance 0 Pain Relevance 0.46
RESULTS: Lidocaine (> or =400 microM) significantly suppressed EGF-stimulated autophosphorylation of the purified EGFR.
Phosphorylation (autophosphorylation) of EGF-stimulated
2) Confidence 0.78 Published 2004 Journal Anesthesiology Section Body Doc Link 15114219 Disease Relevance 0 Pain Relevance 0
Lidocaine (> or = 400 microM) significantly suppressed both the proliferation of HCECs promoted by EGF and EGF-stimulated autophosphorylation of EGFR.
Phosphorylation (autophosphorylation) of EGF-stimulated
3) Confidence 0.78 Published 2004 Journal Anesthesiology Section Body Doc Link 15114219 Disease Relevance 0 Pain Relevance 0
METHODS: To investigate the effect of lidocaine (4 microM-40 mM) on epidermal growth factor (EGF)-stimulated autophosphorylation of EGFR, the authors studied purified EGFR in microtubes.
Phosphorylation (autophosphorylation) of EGF
4) Confidence 0.60 Published 2004 Journal Anesthesiology Section Body Doc Link 15114219 Disease Relevance 0 Pain Relevance 0
METHODS: To investigate the effect of lidocaine (4 microM-40 mM) on epidermal growth factor (EGF)-stimulated autophosphorylation of EGFR, the authors studied purified EGFR in microtubes.
Phosphorylation (autophosphorylation) of epidermal growth factor
5) Confidence 0.60 Published 2004 Journal Anesthesiology Section Body Doc Link 15114219 Disease Relevance 0 Pain Relevance 0
We investigated the effects of lidocaine (40-4000 microM) on proliferation of a human tongue cancer cell line, CAL27, which has a high level of EGFR expression, and also examined the effect of lidocaine on epidermal growth factor (EGF)-stimulated autophosphorylation of EGFR in CAL27 cells.
Phosphorylation (autophosphorylation) of EGF in tongue associated with tongue neoplasms and lidocaine
6) Confidence 0.58 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16551906 Disease Relevance 0.42 Pain Relevance 0.86
Sulindac sulfide inhibits epidermal growth factor-induced phosphorylation of extracellular-regulated kinase 1/2 and Bad in human colon cancer cells.
Phosphorylation (phosphorylation) of epidermal growth factor in colon associated with colon cancer
7) Confidence 0.47 Published 2003 Journal Cancer Res. Section Title Doc Link 12566304 Disease Relevance 1.40 Pain Relevance 0.16
In addition, we noted that in premalignant cells the basal ERK phosphorylation approached the level of OSM-treated cells or EGF-treated cells (Fig. 4B).
Phosphorylation (phosphorylation) of EGF
8) Confidence 0.45 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.22 Pain Relevance 0.07
Lidocaine (> or = 400 microM) significantly suppressed both the proliferation of HCECs promoted by EGF and EGF-stimulated autophosphorylation of EGFR.
Phosphorylation (autophosphorylation) of EGF
9) Confidence 0.34 Published 2004 Journal Anesthesiology Section Body Doc Link 15114219 Disease Relevance 0 Pain Relevance 0
Gefitinib completely abolished EGF-induced phosphorylation of EGFR/MAP kinase and inhibited EGF-induced cell growth and invasion in pancreatic cancer cell lines (Li et al 2004).
Phosphorylation (phosphorylation) of EGF associated with pancreatic cancer
10) Confidence 0.32 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 0.98 Pain Relevance 0.03
Primary antibodies raised against phosphorylated ERK1/2 (Thr202/Tyr204), total ERK1/2, and total EGFR were purchased from Santa Cruz Biotechnology (Santa Cruz, CA); primary antibody against phosphorylated EGFR(Tyr1068), horseradish peroxidase-conjugated anti-mouse and anti-rabbit secondary antibodies, and EGF were purchased from Biosource (Camarillo, CA).
Phosphorylation (phosphorylated) of EGF
11) Confidence 0.27 Published 2005 Journal J Carcinog Section Body Doc Link PMC1208922 Disease Relevance 0.06 Pain Relevance 0.12
Pretreatment with sulindac metabolites for 24 h blocked EGF-induced phosphorylation of both EGFR and ERK1/2 and decreased total EGFR protein expression.
Phosphorylation (phosphorylation) of EGF
12) Confidence 0.27 Published 2005 Journal J Carcinog Section Abstract Doc Link PMC1208922 Disease Relevance 0.70 Pain Relevance 0.23
In addition, there was also no difference of EGF and HB-EGF induced MAPK phosphorylation between control cells and positive clones (Figure 7 A).
Phosphorylation (phosphorylation) of EGF
13) Confidence 0.22 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 0.25 Pain Relevance 0
mol/l genistein in MCF-7 cells correlated with the repression of EGF receptor tyrosine phosphorylation in response to EGF stimulation [23].
Phosphorylation (phosphorylation) of EGF in MCF-7 associated with repression
14) Confidence 0.21 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400678 Disease Relevance 0.47 Pain Relevance 0
Cells treated with EGF for 15 mins were used to control for EGF-induced phosphorylation.


Phosphorylation (phosphorylation) of EGF-induced
15) Confidence 0.15 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2828989 Disease Relevance 0.30 Pain Relevance 0
By using EGF phosphorylation antibody array membranes, we examined the relative level of phosphorylation of specific sites for human EGFR receptors.
Phosphorylation (phosphorylation) of EGF
16) Confidence 0.14 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2777152 Disease Relevance 1.75 Pain Relevance 0.04
The SNIP protein is tyrosine phosphorylated upon integrin-dependent adhesion or EGF treatment, with a potential role as a downstream effector of cell matrix and growth factor signaling that suppresses tumorigenic properties of breast cancer cells [69].
Phosphorylation (phosphorylated) of EGF associated with breast cancer and adhesions
17) Confidence 0.12 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.75 Pain Relevance 0.13

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