INT108339

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Context Info
Confidence 0.58
First Reported 2003
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.95
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (BAD) cytosol (BAD) mitochondrion (BAD)
cytoplasm (BAD)
Anatomy Link Frequency
colon 2
BAD (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 3 95.44 Very High Very High Very High
Pain 8 68.84 Quite High
ischemia 88 53.84 Quite High
Angina 32 5.00 Very Low Very Low Very Low
adenocard 24 5.00 Very Low Very Low Very Low
Kinase C 12 5.00 Very Low Very Low Very Low
bradykinin 12 5.00 Very Low Very Low Very Low
Inflammation 9 5.00 Very Low Very Low Very Low
Opioid 8 5.00 Very Low Very Low Very Low
antagonist 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 49 99.68 Very High Very High Very High
Colon Cancer 32 99.60 Very High Very High Very High
Apoptosis 270 99.32 Very High Very High Very High
Death 52 96.56 Very High Very High Very High
INFLAMMATION 15 94.72 High High
Carcinoma 9 92.88 High High
Rectal Cancer 2 87.00 High High
Pressure And Volume Under Development 8 74.08 Quite High
Pain 8 68.84 Quite High
Cv Unclassified Under Development 84 53.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sulindac sulfide inhibits epidermal growth factor-induced phosphorylation of extracellular-regulated kinase 1/2 and Bad in human colon cancer cells.
Positive_regulation (-) of Phosphorylation (phosphorylation) of Bad in colon associated with colon cancer
1) Confidence 0.58 Published 2003 Journal Cancer Res. Section Title Doc Link 12566304 Disease Relevance 1.44 Pain Relevance 0.17
The antiapoptotic protein Bcl-2 and inactive phosphorylated form of Bad (Figures 1 and 2) were increased in all cancer specimens, with no differences among Duke's stages, whereas the proapototic proteins Bad and Bak were decreased (Figure 2).


Neg (no) Positive_regulation (increased) of Phosphorylation (form) of Bad associated with cancer
2) Confidence 0.24 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2762309 Disease Relevance 0.58 Pain Relevance 0
Recent studies have shown that pharmacological activation of these kinases is associated with recruitment of anti-apoptotic signaling components such as the phosphorylation and inhibition of the proapoptotic proteins Bax and Bad, the inhibition of caspase 3 activation, the phosphorylation and activation of p70S6K (which acts to inhibit Bad) and the phosphorylation and activation of the antiapoptotic protein Bcl-2 (Harada et al 2001; Hausenloy and Yellon 2007).
Positive_regulation (activation) of Phosphorylation (phosphorylation) of Bad associated with apoptosis
3) Confidence 0.22 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291307 Disease Relevance 0.51 Pain Relevance 0.10
Recent studies have shown that pharmacological activation of these kinases is associated with recruitment of anti-apoptotic signaling components such as the phosphorylation and inhibition of the proapoptotic proteins Bax and Bad, the inhibition of caspase 3 activation, the phosphorylation and activation of p70S6K (which acts to inhibit Bad) and the phosphorylation and activation of the antiapoptotic protein Bcl-2 (Harada et al 2001; Hausenloy and Yellon 2007).
Positive_regulation (activation) of Phosphorylation (phosphorylation) of Bad associated with apoptosis
4) Confidence 0.22 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291307 Disease Relevance 0.49 Pain Relevance 0.10
Recent studies have shown that pharmacological activation of these kinases is associated with recruitment of anti-apoptotic signaling components such as the phosphorylation and inhibition of the proapoptotic proteins Bax and Bad, the inhibition of caspase 3 activation, the phosphorylation and activation of p70S6K (which acts to inhibit Bad) and the phosphorylation and activation of the antiapoptotic protein Bcl-2 (Harada et al 2001; Hausenloy and Yellon 2007).
Positive_regulation (activation) of Phosphorylation (phosphorylation) of Bad associated with apoptosis
5) Confidence 0.22 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291307 Disease Relevance 0.49 Pain Relevance 0.10
Recent studies have shown that pharmacological activation of these kinases is associated with recruitment of anti-apoptotic signaling components such as the phosphorylation and inhibition of the proapoptotic proteins Bax and Bad, the inhibition of caspase 3 activation, the phosphorylation and activation of p70S6K (which acts to inhibit Bad) and the phosphorylation and activation of the antiapoptotic protein Bcl-2 (Harada et al 2001; Hausenloy and Yellon 2007).
Positive_regulation (activation) of Phosphorylation (phosphorylation) of Bad associated with apoptosis
6) Confidence 0.22 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291307 Disease Relevance 0.44 Pain Relevance 0.09

General Comments

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