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Context Info
Confidence 0.42
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 8.75
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (BAD) cytosol (BAD) mitochondrion (BAD)
cytoplasm (BAD)
BAD (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 52 98.02 Very High Very High Very High
cINOD 23 93.92 High High
agonist 14 86.04 High High
cytokine 15 83.44 Quite High
Clonidine 3 82.84 Quite High
Bile 1 77.16 Quite High
cerebral cortex 2 75.00 Quite High
antagonist 21 69.76 Quite High
Angina 1 62.80 Quite High
Inflammation 35 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 417 100.00 Very High Very High Very High
Hypoxia 15 99.90 Very High Very High Very High
Cancer 228 99.28 Very High Very High Very High
Pancreatic Cancer 49 99.04 Very High Very High Very High
INFLAMMATION 43 92.48 High High
Stomach Cancer 5 91.60 High High
Death 40 90.32 High High
Glioblastoma 2 90.16 High High
Rectal Cancer 1 88.40 High High
Colon Cancer 65 87.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phosphorylation of Ser112 by ERK1/2 inactivates Bad and protects the tumor cell from apoptosis.
Positive_regulation (inactivates) of Bad associated with cancer and apoptosis
1) Confidence 0.42 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12566304 Disease Relevance 1.46 Pain Relevance 0.17
by an increase in Bad (Figure 4(c)).
Positive_regulation (increase) of Bad
2) Confidence 0.31 Published 2007 Journal PPAR Research Section Body Doc Link PMC1852897 Disease Relevance 0.44 Pain Relevance 0.06
induction, Bcl-2 decrease, and Bad
Positive_regulation (induction) of Bad
3) Confidence 0.22 Published 2007 Journal PPAR Research Section Body Doc Link PMC1852897 Disease Relevance 1.28 Pain Relevance 0
Western blot analysis of sensitive and resistant LDC clonal lines confirmed increases in cyclin D1, STAT6, Bcl-xL, and BAD, with decreased expression of caspase 1.
Positive_regulation (increases) of BAD
4) Confidence 0.19 Published 2005 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 16005468 Disease Relevance 1.11 Pain Relevance 0.06
The COX-2 inhibitor, indeed, was able to increase the level of PTEN, leading to a decrease of Akt phosphorylation and activation of Bad [114].
Positive_regulation (activation) of Bad associated with cox-2 inhibitor
5) Confidence 0.14 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.29 Pain Relevance 0.27
In our study, corresponding with the alteration of Akt, pBad (pS136) was regulated by constitutive and induced FAK phosphorylation in pancreatic cancer cells.
Positive_regulation (induced) of pBad associated with pancreatic cancer
6) Confidence 0.12 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.90 Pain Relevance 0
Therefore, the pro-apoptotic Bad protein was active after 1 hour of STS treatment since the dephosphorylated form of Bad was primarily detected.
Positive_regulation (active) of Bad associated with apoptosis
7) Confidence 0.08 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.55 Pain Relevance 0
We propose that during hypoxia the increased ratio of (pro-apoptotic Bad and Bax/anti-apoptotic Bcl-xl and Bcl-2) in all the three compartments, will lead to altered mitochondrial and nuclear membrane permeability as well as caspase-9 activation in the cytosolic compartment.
Positive_regulation (increased) of Bad associated with hypoxia and apoptosis
8) Confidence 0.04 Published 2008 Journal Neurochem. Res. Section Abstract Doc Link 18293086 Disease Relevance 1.73 Pain Relevance 0.28

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