INT108352

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Context Info
Confidence 0.59
First Reported 1999
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 0.68
Pain Relevance 1.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkaca) Golgi apparatus (Prkaca) plasma membrane (Prkaca)
nucleus (Prkaca) protein complex (Prkaca) kinase activity (Prkaca)
Anatomy Link Frequency
sensory neurons 2
neurons 2
Prkaca (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 14 100.00 Very High Very High Very High
IPN 3 99.86 Very High Very High Very High
qutenza 15 97.60 Very High Very High Very High
long-term potentiation 9 96.64 Very High Very High Very High
Pyramidal cell 21 89.84 High High
agonist 99 85.56 High High
Hippocampus 5 71.20 Quite High
nociceptor 6 70.72 Quite High
Inflammation 5 70.72 Quite High
Neuropeptide 3 67.92 Quite High
Disease Link Frequency Relevance Heat
Inflammatory Pain 3 99.86 Very High Very High Very High
Nociception 22 97.64 Very High Very High Very High
INFLAMMATION 6 70.72 Quite High
Neuroblastoma 1 59.72 Quite High
Increased Venous Pressure Under Development 11 53.52 Quite High
Ganglion Cysts 8 53.08 Quite High
Pain 5 29.60 Quite Low
Schizophrenia 14 5.00 Very Low Very Low Very Low
Targeted Disruption 10 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PKA inhibitor could significantly inhibit this change; (4) Concomitant administration of naloxone could block the changes in PKA activity and c-Fos phosphorylation described above.
Regulation (changes) of Phosphorylation (phosphorylation) of PKA
1) Confidence 0.59 Published 1999 Journal Zhongguo Yi Xue Ke Xue Yuan Xue Bao Section Body Doc Link 12567447 Disease Relevance 0.06 Pain Relevance 0
As for the effect of PKA phosphorylation on SK channels natively expressed in neurons, a recent study has shown that during LTP induction SK2 channels are internalized from the postsynaptic density into CA1 dendritic spines in a PKA-dependent manner [84].
Regulation (effect) of Phosphorylation (phosphorylation) of PKA in neurons associated with long-term potentiation
2) Confidence 0.12 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0 Pain Relevance 0.20
Most of these channels are modulated by PKA and PKC mediated phosphorylation.
Regulation (modulated) of Phosphorylation (phosphorylation) of PKA associated with kinase c
3) Confidence 0.11 Published 2006 Journal Mol Pain Section Body Doc Link PMC1563450 Disease Relevance 0.47 Pain Relevance 0.47
S5 shows the effect of the PKA-catalyzed phosphorylation of tomosyn on the oligomerization of the SNARE complex and binding of SNAP-25 to the WD-40 repeat domain of tomosyn.


Regulation (effect) of Phosphorylation (phosphorylation) of PKA
4) Confidence 0.10 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0.05 Pain Relevance 0
We conclude that Ca2+-dependent desensitization of TRPV1 might be in part regulated through channel dephosphorylation by calcineurin and channel phosphorylation by PKA possibly involving Thr370 as a key amino acid residue.
Regulation (regulated) of Phosphorylation (phosphorylation) of PKA
5) Confidence 0.07 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15691846 Disease Relevance 0 Pain Relevance 0.38
The capsaicin receptor TRPV1, a non-selective cation channel of sensory neurons involved in the sensation of inflammatory pain, is a target of PKA-mediated phosphorylation.
Regulation (target) of Phosphorylation (phosphorylation) of PKA in sensory neurons associated with qutenza and ipn
6) Confidence 0.04 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 14506258 Disease Relevance 0.10 Pain Relevance 0.37
is not a direct target for either PKA or PKG phosphorylation or inhibition, but its RhoA-mediated signaling would be sensitive to RhoA phosphorylation by either second messenger kinase.
Regulation (target) of Phosphorylation (phosphorylation) of PKA
7) Confidence 0.03 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
had been previously identified as a target for PKA phosphorylation and heterologous desensitization [33].
Regulation (target) of Phosphorylation (phosphorylation) of PKA
8) Confidence 0.02 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.11

General Comments

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