INT108354

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.41
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 6.24
Pain Relevance 4.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkaca) Golgi apparatus (Prkaca) plasma membrane (Prkaca)
nucleus (Prkaca) protein complex (Prkaca) kinase activity (Prkaca)
Anatomy Link Frequency
HT-29 6
platelets 2
molar 2
Prkaca (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 54 98.40 Very High Very High Very High
nMDA receptor 35 98.30 Very High Very High Very High
fluoxetine 10 97.28 Very High Very High Very High
long-term potentiation 136 95.44 Very High Very High Very High
Kinase C 24 94.80 High High
Inflammation 71 94.16 High High
depression 83 93.28 High High
Inflammatory response 19 91.52 High High
5HT 141 91.36 High High
bradykinin 7 91.12 High High
Disease Link Frequency Relevance Heat
Stress 28 99.78 Very High Very High Very High
Targeted Disruption 218 99.48 Very High Very High Very High
Congenital Anomalies 9 97.88 Very High Very High Very High
Anxiety Disorder 147 97.72 Very High Very High Very High
Hypersensitivity 4 95.56 Very High Very High Very High
Injury 7 94.96 High High
INFLAMMATION 109 94.16 High High
Depression 84 93.28 High High
Neurodegenerative Disease 25 89.44 High High
Pain 136 88.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The opposite effects of isoproterenol on the kainate- and veratridine-evoked releases may reflect prevention of the cyclic AMP-protein kinase A (PKA) phosphorylation cascade in striatal glutamatergic signal transduction.
Negative_regulation (prevention) of Phosphorylation (phosphorylation) of PKA
1) Confidence 0.41 Published 2003 Journal Neurochem. Int. Section Abstract Doc Link 12742088 Disease Relevance 0 Pain Relevance 0.40
PKA inhibitor could significantly inhibit this change; (4) Concomitant administration of naloxone could block the changes in PKA activity and c-Fos phosphorylation described above.
Negative_regulation (block) of Phosphorylation (phosphorylation) of PKA
2) Confidence 0.41 Published 1999 Journal Zhongguo Yi Xue Ke Xue Yuan Xue Bao Section Body Doc Link 12567447 Disease Relevance 0.06 Pain Relevance 0
Surprisingly, we found that phosphorylation of PKA site was decreased in neurabin KO mice to 36.0±9.0 % of the levels in wild-type mice (n?
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of PKA associated with targeted disruption
3) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 0.63 Pain Relevance 0.14
The CMS procedure inhibited hippocampal protein kinase A (PKA) activity, extracellular signal-regulated kinases (ERK1/2), and calcium/calmodulin-dependent protein kinase IV (CaMKIV) phosphorylation in AQP4(+/+) and AQP4(-/-) mice.
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of PKA associated with stress
4) Confidence 0.29 Published 2009 Journal Neuropsychopharmacology Section Abstract Doc Link 18923397 Disease Relevance 1.43 Pain Relevance 0.68
The disinhibition of PKA when phosphoThr75 is dephosphorylated has been suggested to be an important part of the potentiating effect of DARPP-32 on PKA activity [65]: PKA enhances PP2A activity via phosphorylation; then PP2Ap dephosphorylates phosphoThr75 at an accelerated rate and the decrease in phosphoThr75 leads to more active PKA.
Negative_regulation (disinhibition) of Phosphorylation (dephosphorylated) of PKA
5) Confidence 0.23 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.14
Moreover, increased AMPA receptor but not NMDA receptor-mediated synaptic transmission was found in neurabin KO mice, and is accompanied by decreased phosphorylation of GluR1 at the PKA site (Ser845) but no change at the CaMKII/PKC site (Ser831).
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of PKA associated with targeted disruption and nmda receptor
6) Confidence 0.22 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2169299 Disease Relevance 1.04 Pain Relevance 0.37
TRPV1 can be sensitized by phosphorylation through PKC, PKA and Ca2+/CaM-dependent kinsase II [17-20].
Negative_regulation (sensitized) of Phosphorylation (phosphorylation) of PKA
7) Confidence 0.14 Published 2006 Journal Mol Pain Section Body Doc Link PMC1660571 Disease Relevance 1.37 Pain Relevance 1.14
Interestingly, this effect of PKA phosphorylation is dependent on the ER retention motif RRR (whose sequence is shared with a phosphorylation site), but is independent of the masking effect of the ?
Negative_regulation (effect) of Phosphorylation (phosphorylation) of PKA
8) Confidence 0.12 Published 2010 Journal Neuroscience Letters Section Body Doc Link PMC2977848 Disease Relevance 0.25 Pain Relevance 0.20
Thus, in HT-29, Lovo and SW480 cells low nano molar concentrations of PGE2 reduced PKA substrate phosphorylation, in the absence of any ostensible reduction of cAMP levels.
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of PKA in HT-29
9) Confidence 0.08 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.06 Pain Relevance 0
For example, in HT-29 cells 1 nM, 10 nM and 100 nM PGE2 all lead to a reduced phosphorylation of PKA substrates, indicative of a reduction in cAMP levels, while only 10 nM PGE2 induces a detectable drop in cAMP levels as measured by the radioimmunoassay.
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of PKA in HT-29
10) Confidence 0.08 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.13 Pain Relevance 0.04
Low nano molar doses of PGE2 caused either no change or a reduction in PKA substrate phosphorylation, while ?
Negative_regulation (reduction) of Phosphorylation (phosphorylation) of PKA in molar
11) Confidence 0.08 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0 Pain Relevance 0
Rolipram, a PDE4 inhibitor increasing cAMP levels, reversed the inhibition of PKA activity and CREB phosphorylation most probably by favoring the dissociation of regulatory and catalytic subunits of PKA and the restoration of PKA activity (Vitolo et al 2002).
Negative_regulation (inhibition) of Phosphorylation (phosphorylation) of PKA
12) Confidence 0.06 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2518390 Disease Relevance 0.17 Pain Relevance 0.09
Effective use of these compounds was confirmed by documenting the inhibition of PKA dependent protein phosphorylation in our same model system.
Negative_regulation (inhibition) of Phosphorylation (phosphorylation) of PKA
13) Confidence 0.06 Published 2005 Journal Cell Commun Signal Section Body Doc Link PMC1198236 Disease Relevance 0.39 Pain Relevance 0.24
We suspect that a drop in cAMP levels, as reflected by a marked reduction in PKA substrate phosphorylation e.g. by 1 or 100 nM PGE2 in HT-29 cells (Fig. 3C) did largely pass undetected in the cAMP measurements.
Negative_regulation (reduction) of Phosphorylation (phosphorylation) of PKA in HT-29
14) Confidence 0.06 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0 Pain Relevance 0
Importantly, a second experimental readout for cAMP levels, the phosphorylation of substrates of the cAMP target PKA, yielded qualitatively the same results, but in several cases it evidenced a more dramatic reduction of cAMP/PKA signalling in response to mitogenic PGE2 doses than those disclosed by the RIA assay.
Negative_regulation (reduction) of Phosphorylation (phosphorylation) of PKA
15) Confidence 0.05 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.21 Pain Relevance 0.04
Disruption of phosphorylation at potential PKA phosphorylationsite S116D (replacing serine (S) residue with alanine (A)) [16, 137] prevented desensitization.
Negative_regulation (Disruption) of Phosphorylation (phosphorylationsite) of PKA
16) Confidence 0.04 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 0.06 Pain Relevance 0.49
is not a direct target for either PKA or PKG phosphorylation or inhibition, but its RhoA-mediated signaling would be sensitive to RhoA phosphorylation by either second messenger kinase.
Negative_regulation (inhibition) of Phosphorylation (phosphorylation) of PKA
17) Confidence 0.03 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
Abnormalities in the PKA have also been reported with decreased c-AMP-stimulated PKA activity (Perez et al 2000) and a reduced phosphorylation state of the PKA substrate Rap1 (Tardito et al 2001) in the platelets of OCD patients.
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of PKA in platelets associated with congenital anomalies and anxiety disorder
18) Confidence 0.02 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2416754 Disease Relevance 0.44 Pain Relevance 0.41

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox