INT108358

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Context Info
Confidence 0.80
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 6.33
Pain Relevance 2.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (FOS) aging (FOS) nucleolus (FOS)
nucleus (FOS)
Anatomy Link Frequency
SH-SY5Y 3
macrophages 1
monocytes 1
spinal cord 1
brainstem 1
FOS (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 10 99.34 Very High Very High Very High
Visceral pain 18 98.02 Very High Very High Very High
Spinal cord 27 97.84 Very High Very High Very High
medulla 2 97.32 Very High Very High Very High
amygdala 68 90.00 High High
central sensitization 13 85.00 Quite High
cytokine 47 83.64 Quite High
Glutamate receptor 3 82.64 Quite High
Dynorphin 2 81.92 Quite High
depression 8 81.52 Quite High
Disease Link Frequency Relevance Heat
Neuroblastoma 8 99.12 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

18 98.02 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

48 97.20 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 283 97.00 Very High Very High Very High
Nociception 25 92.64 High High
Anxiety Disorder 16 88.04 High High
Cirrhosis 45 86.36 High High
Depression 8 81.52 Quite High
Pain 24 78.72 Quite High
Post-traumatic Stress Disorder 6 76.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
But no changes were observed in membrane PKA activity; (3) In morphine dependent-like cells decreased c-Fos phosphorylation level was observed.
Phosphorylation (phosphorylation) of c-Fos
1) Confidence 0.80 Published 1999 Journal Zhongguo Yi Xue Ke Xue Yuan Xue Bao Section Body Doc Link 12567447 Disease Relevance 0.07 Pain Relevance 0
CONCLUSIONS: The up-regulation of cAMP system in differentiated SH-SY5Y cells may be involved in the development of morphine dependent and in morphine dependent-like SH-SY5Y cells and PKA was suggested to regulate c-Fos dephosphorylation through activating phosphatase and then activate some genes transcription, which might be one of the important mechanism regardingas cellular adaptive responses underlying dependence to opioid drugs.


Phosphorylation (dephosphorylation) of c-Fos in SH-SY5Y
2) Confidence 0.80 Published 1999 Journal Zhongguo Yi Xue Ke Xue Yuan Xue Bao Section Body Doc Link 12567447 Disease Relevance 0 Pain Relevance 0
OBJECTIVE: To further understand the effects of long-term morphine exposure on the cAMP system and c-Fos phosphorylation in differentiated SH-SY5Y human neuroblastoma cells.
Phosphorylation (phosphorylation) of c-Fos in SH-SY5Y associated with neuroblastoma and morphine
3) Confidence 0.80 Published 1999 Journal Zhongguo Yi Xue Ke Xue Yuan Xue Bao Section Abstract Doc Link 12567447 Disease Relevance 0.10 Pain Relevance 0.17
PKA inhibitor could significantly inhibit this change; (4) Concomitant administration of naloxone could block the changes in PKA activity and c-Fos phosphorylation described above.
Phosphorylation (phosphorylation) of c-Fos
4) Confidence 0.80 Published 1999 Journal Zhongguo Yi Xue Ke Xue Yuan Xue Bao Section Body Doc Link 12567447 Disease Relevance 0.06 Pain Relevance 0
[Effects of long-term morphine exposure on the cAMP system and c-Fos phosphorylation in differentiated SH-SY5Y cells].
Phosphorylation (phosphorylation) of c-Fos in SH-SY5Y associated with morphine
5) Confidence 0.80 Published 1999 Journal Zhongguo Yi Xue Ke Xue Yuan Xue Bao Section Title Doc Link 12567447 Disease Relevance 0 Pain Relevance 0.20
Colorectal distension (CRD) is commonly used to model visceral pain in experimental animals and induces significant up-regulation of the immediate early gene product c-Fos, as well as the phosphorylated extracellular signal-regulated kinase (p-ERK) in the spinal cord, brainstem, limbic areas, and neocortex in conscious rats (10-13).
Phosphorylation (phosphorylated) of c-Fos in brainstem associated with medulla, visceral pain and spinal cord
6) Confidence 0.61 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2967003 Disease Relevance 1.35 Pain Relevance 0.78
Like other transcription factors, such as AP-1 proteins, c-fos, and c-Jun, phosphorylated CREB may participate in the downstream signal transduction cascade in the longer lasting changes in synaptic plasticity.
Phosphorylation (phosphorylated) of c-fos
7) Confidence 0.61 Published 2005 Journal Mol Pain Section Body Doc Link PMC1224868 Disease Relevance 0.43 Pain Relevance 0.71
Vpr activates the DNA binding activity of AP-1 by promoting the phosphorylation of cFos and cJun in monocytes and macrophages [267].
Phosphorylation (phosphorylation) of cFos in monocytes
8) Confidence 0.29 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.61 Pain Relevance 0
Colorectal distension (CRD) is commonly used to model visceral pain in experimental animals and induces significant up-regulation of the immediate early gene product c-Fos, as well as the phosphorylated extracellular signal-regulated kinase (p-ERK) in the spinal cord, brainstem, limbic areas, and neocortex in conscious rats (10-13).
Phosphorylation (phosphorylated) of c-Fos in spinal cord associated with medulla, visceral pain and spinal cord
9) Confidence 0.21 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2967003 Disease Relevance 1.35 Pain Relevance 0.78
We obtained similar results using antibodies specific for phosphorylated Fos (Figure 3D, E).
Phosphorylation (phosphorylated) of Fos
10) Confidence 0.16 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2944801 Disease Relevance 0 Pain Relevance 0.04
Vpr activates the DNA binding activity of AP-1 by promoting the phosphorylation of cFos and cJun in monocytes and macrophages [267].
Phosphorylation (phosphorylation) of cFos in macrophages
11) Confidence 0.10 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.61 Pain Relevance 0
In 2003, Bataller and coworkers [318] were the first to identify the presence of components of NOX in HSC/MFs, suggesting that the pro-fibrogenic action of Ang II, as already delineated in in vivo and in vitro studies [319,320], is dependent on the associated activation of NOX and the related ROS-dependent activation of MAPKs, phosphorylation of c-Akt and increased AP-1 DNA binding activity [318], events blocked by the specific NOX inhibitor DPI (diphenyl-phenyleneiodonium) or the inhibitor of Ang II type 1 receptor (AT1), losartan.
Phosphorylation (phosphorylation) of AP-1
12) Confidence 0.08 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.26 Pain Relevance 0.08
phosphorylates several transcription factors, including AP-1, CREB, HSF-1, NFAT, C/EBP, and NF-kB [34], Ngn2 [55], and Smad3/4 [56].
Phosphorylation (phosphorylates) of AP-1 in HSF
13) Confidence 0.01 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.26 Pain Relevance 0.04

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