INT10836

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Context Info
Confidence 0.59
First Reported 1992
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 95
Total Number 95
Disease Relevance 52.59
Pain Relevance 24.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL8) extracellular space (IL8) extracellular region (IL8)
intracellular (IL8)
Anatomy Link Frequency
monocytes 5
neutrophils 5
HCEC 4
blood 3
plasma 2
IL8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1782 100.00 Very High Very High Very High
cytokine 1094 100.00 Very High Very High Very High
rheumatoid arthritis 482 100.00 Very High Very High Very High
chemokine 346 100.00 Very High Very High Very High
ischemia 17 100.00 Very High Very High Very High
fibrosis 39 99.96 Very High Very High Very High
substance P 36 99.92 Very High Very High Very High
dexamethasone 53 99.84 Very High Very High Very High
Chronic pancreatitis 78 99.64 Very High Very High Very High
tolerance 28 99.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1954 100.00 Very High Very High Very High
Cancer 535 100.00 Very High Very High Very High
Rheumatoid Arthritis 501 100.00 Very High Very High Very High
Necrosis 77 100.00 Very High Very High Very High
Cv Unclassified Under Development 16 100.00 Very High Very High Very High
Impaired Glucose Tolerance 14 100.00 Very High Very High Very High
Fibrosis 43 99.96 Very High Very High Very High
Infection 325 99.82 Very High Very High Very High
Chronic Sinusitis 100 99.64 Very High Very High Very High
Pancreatitis 80 99.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Suppression of IL-8 by anesthetics and sedatives may predispose postoperative and intensive care patients to infection.
Negative_regulation (Suppression) of IL-8 associated with infection
1) Confidence 0.59 Published 1998 Journal Anesth. Analg. Section Abstract Doc Link 9620522 Disease Relevance 0.15 Pain Relevance 0.37
The differential effect may be explained in part by the reduction of IL-8 receptors of newborn neutrophils after morphine exposure.


Negative_regulation (reduction) of IL-8 in neutrophils
2) Confidence 0.59 Published 2008 Journal Clin J Pain Section Body Doc Link 18180640 Disease Relevance 0 Pain Relevance 0
Treatment of amnion cells stimulated by IL-1 beta with cycloheximide resulted in increased IL-8 production, while incubation of IL-1 beta treated amnion cells with actinomycin D resulted in a concentration-dependent decrease in detectable amounts of IL-8.
Negative_regulation (decrease) of IL-8 in amnion
3) Confidence 0.58 Published 1992 Journal J. Cell. Physiol. Section Abstract Doc Link 1522134 Disease Relevance 0.77 Pain Relevance 0.41
Inhibition of IL-8 chemotaxis was not restricted to ketoprofen isomer as it could be observed also with drugs belonging to different classes of NSAIDs and it was obtained at drug concentration superimposable to plasma levels after therapeutic administration in patients.
Negative_regulation (Inhibition) of IL-8 in plasma associated with cinod
4) Confidence 0.57 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11331079 Disease Relevance 0.20 Pain Relevance 0.50
Our results show that R- and S-ketoprofen, independently of their potency as PG inhibitors, proved very efficacious in selective inhibition of interleukin-8 (IL-8) chemotaxis.
Negative_regulation (inhibition) of IL-8 associated with potency
5) Confidence 0.57 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11331079 Disease Relevance 0.21 Pain Relevance 0.50
The inhibitory effect of NHE inhibition on IL-8 was associated with a decrease in IL-8 mRNA accumulation.
Negative_regulation (inhibition) of IL-8
6) Confidence 0.53 Published 2002 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12065299 Disease Relevance 0.89 Pain Relevance 0.33
Finally, a reduction in IL-8 has caused recent speculation about its importance as a pathogenic factor in chronic inflammatory diseases such as helicobacter-associated duodenal ulcer [44] and Crohn’s disease [45].
Negative_regulation (reduction) of IL-8 associated with inflammation, duodenal ulcer and disease
7) Confidence 0.47 Published 2010 Journal The Open Dentistry Journal Section Body Doc Link PMC2874215 Disease Relevance 0.88 Pain Relevance 0.09
A dose-response relationship for prednisolone was tested in previous studies and similar to Wallwork et al. we found optimal inhibition of IL-8 levels at a concentration of 10-5 M prednisolone [6,10].
Negative_regulation (inhibition) of IL-8
8) Confidence 0.45 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2507710 Disease Relevance 0.21 Pain Relevance 0.03
Wallwork et al. who used cultures of whole sections of sinus mucosa from CRS patients found a reduction of IL-8 levels after 24 hours of incubation with 10-5 M clarithromycin [6].
Negative_regulation (reduction) of IL-8 in sinus associated with chronic sinusitis
9) Confidence 0.45 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2507710 Disease Relevance 0.28 Pain Relevance 0.12
Specific inhibition of CXCL8 by therapy with monoclonal antibody has been shown to be effective in an acute model of arthritis [60].
Negative_regulation (inhibition) of CXCL8 associated with arthritis
10) Confidence 0.43 Published 2001 Journal Arthritis Res Section Body Doc Link PMC17826 Disease Relevance 0.92 Pain Relevance 0.54
Antibodies directed at CXCR1 and CXCR2 are capable of inhibiting IL-8 induced migration of HMEC, which indicates that these two receptors are critical for the IL-8 angiogenic response.
Negative_regulation (inhibiting) of IL-8 in HMEC
11) Confidence 0.43 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 0.54 Pain Relevance 0.09
A novel class of 2-(R)-phenylpropionamides has been recently reported to inhibit in vitro and in vivo interleukin-8 (CXCL8)-induced biological activities.
Negative_regulation (inhibit) of CXCL8
12) Confidence 0.43 Published 2005 Journal J. Med. Chem. Section Abstract Doc Link 15801837 Disease Relevance 0.09 Pain Relevance 0.09
A novel class of 2-(R)-phenylpropionamides has been recently reported to inhibit in vitro and in vivo interleukin-8 (CXCL8)-induced biological activities.
Negative_regulation (inhibit) of interleukin-8
13) Confidence 0.43 Published 2005 Journal J. Med. Chem. Section Abstract Doc Link 15801837 Disease Relevance 0.09 Pain Relevance 0.09
CONCLUSIONS: Newborn neutrophils had reduced chemotaxis toward IL-8.
Negative_regulation (reduced) of IL-8 in neutrophils
14) Confidence 0.43 Published 2008 Journal Clin J Pain Section Body Doc Link 18180640 Disease Relevance 0 Pain Relevance 0
The present study was aimed at defining the localization of IL-8 mRNA as well as IL-8 protein at the feto-maternal interface using in situ hybridization and immunohistochemical staining.
Negative_regulation (defining) of IL-8
15) Confidence 0.43 Published 1994 Journal J. Reprod. Immunol. Section Abstract Doc Link 7738906 Disease Relevance 0.26 Pain Relevance 0.10
Reduction of IL-8 migration by ketoprofen isomers was paralleled by selective inhibition of PMN response in terms of intracellular calcium concentration ([Ca(2+)]i) increase and extracellular signal regulated kinase(ERK)-2 activation, two intracellular mediators reported to be critical for PMN activities.
Negative_regulation (Reduction) of IL-8
16) Confidence 0.42 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11331079 Disease Relevance 0.17 Pain Relevance 0.54
Our results show that R- and S-ketoprofen, independently of their potency as PG inhibitors, proved very efficacious in selective inhibition of interleukin-8 (IL-8) chemotaxis.
Negative_regulation (inhibition) of interleukin-8 associated with potency
17) Confidence 0.42 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11331079 Disease Relevance 0.21 Pain Relevance 0.50
It is concluded that inhibition of IL-8 chemotaxis could represent a new clinical target for ketoprofen isomers and, in fact, contribute to the anti-inflammatory activity of NSAIDs.
Negative_regulation (inhibition) of IL-8 associated with inflammation and cinod
18) Confidence 0.42 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11331079 Disease Relevance 0.15 Pain Relevance 0.35
Markers that changed after treatment were as follows: (1) nitric oxide synthase and cyclic guanosine monophosphate increased with oral L-arginine; (2) ECP decreased with subcutaneous heparin; (3) prostaglandin E(2) and kallikrein decreased after bladder distention; (4) neutrophil chemotactic activity decreased after dimethyl sulfoxide; (5) IL-2 inhibitor decreased after oral nifedipine; (6) IL-2, IL-6, and IL-8 decreased after bacille Calmette-Guérin (BCG) vaccine; and (7) APF and heparin-binding epidermal growth factor changed to or toward normal levels after bladder distention or sacral nerve stimulation.
Negative_regulation (decreased) of IL-8 in nerve
19) Confidence 0.41 Published 2001 Journal Urology Section Abstract Doc Link 11378044 Disease Relevance 0.52 Pain Relevance 0.48
These results suggest that rebamipide may protect against the mucosal inflammation associated with H. pylori infection through inhibition of a proinflammatory cytokine, IL-8.
Negative_regulation (inhibition) of IL-8 associated with mucositis, inflammation, infection and cytokine
20) Confidence 0.38 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9753246 Disease Relevance 0.87 Pain Relevance 0.16

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