INT108360

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Context Info
Confidence 0.66
First Reported 1999
Last Reported 1999
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Prkaca, FOS) nucleoplasm (FOS) mitochondrion (Prkaca)
aging (FOS) Golgi apparatus (Prkaca) protein complex (Prkaca)
Anatomy Link Frequency
SH-SY5Y 2
Prkaca (Mus musculus)
FOS (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 2 50.00 Quite Low
Disease Link Frequency Relevance Heat
Neuroblastoma 1 49.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: The up-regulation of cAMP system in differentiated SH-SY5Y cells may be involved in the development of morphine dependent and in morphine dependent-like SH-SY5Y cells and PKA was suggested to regulate c-Fos dephosphorylation through activating phosphatase and then activate some genes transcription, which might be one of the important mechanism regardingas cellular adaptive responses underlying dependence to opioid drugs.


PKA Regulation (regulate) of Phosphorylation (dephosphorylation) of c-Fos in SH-SY5Y
1) Confidence 0.66 Published 1999 Journal Zhongguo Yi Xue Ke Xue Yuan Xue Bao Section Body Doc Link 12567447 Disease Relevance 0 Pain Relevance 0

General Comments

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