INT108363

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Context Info
Confidence 0.45
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.09
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (Chrm4)
Anatomy Link Frequency
spinal cord 2
MSN 1
internal 1
Chrm4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid receptor 1 1 99.24 Very High Very High Very High
Glutamate receptor 1 98.44 Very High Very High Very High
Spinal cord 6 50.00 Quite Low
Morphine 6 50.00 Quite Low
medulla 6 50.00 Quite Low
withdrawal 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 1 86.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
METHODS: The mRNA expression level of m1, m2, m3, m4 and m5 were determined by RT-PCR, the beta-actin mRNA expression was used as internal control.
Gene_expression (expression) of m4 in internal
1) Confidence 0.45 Published 2002 Journal Yao Xue Xue Bao Section Body Doc Link 12567774 Disease Relevance 0 Pain Relevance 0
RESULTS: The mRNA level of m1, m2, m3, m4 and m5 in spinal cord and m1 and m2 in brainstem were increased significantly during morphine dependence, and the levels of m1, m2, m3 and m4 in spinal cord and m1 in brainstem were decreased 1 h after the injection of naloxone (4 mg.kg-1, i.p.) in morphine dependent rats.
Gene_expression (levels) of m4 in spinal cord
2) Confidence 0.45 Published 2002 Journal Yao Xue Xue Bao Section Body Doc Link 12567774 Disease Relevance 0 Pain Relevance 0
The levels of m1, m2, m3 and m5 in spinal cord were increased by pretreatment with pirenzepine and the levels of m2, m3 and m4 in spinal cord were increased by pretreatment with scopolamine.
Gene_expression (levels) of m4 in spinal cord
3) Confidence 0.39 Published 2002 Journal Yao Xue Xue Bao Section Body Doc Link 12567774 Disease Relevance 0 Pain Relevance 0
In the absence of Ctip2, MSN do not fully differentiate, as demonstrated by dramatically reduced expression of a large number of MSN markers, including DARPP-32, FOXP1, Chrm4, Reelin, MOR1 (mu-opioid receptor 1), glutamate receptor 1, and Plexin-D1.
Gene_expression (expression) of Chrm4 in MSN associated with glutamate receptor and opioid receptor 1
4) Confidence 0.08 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18199763 Disease Relevance 0.09 Pain Relevance 0.15

General Comments

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