INT10837

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Context Info
Confidence 0.70
First Reported 1992
Last Reported 2011
Negated 8
Speculated 11
Reported most in Body
Documents 294
Total Number 311
Disease Relevance 190.08
Pain Relevance 70.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL8) extracellular space (IL8) extracellular region (IL8)
intracellular (IL8)
Anatomy Link Frequency
monocyte 33
fibroblasts 21
epithelial cells 18
endothelial cells 17
neutrophils 16
IL8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 4574 100.00 Very High Very High Very High
cytokine 3338 100.00 Very High Very High Very High
chemokine 1773 100.00 Very High Very High Very High
Inflammatory mediators 336 100.00 Very High Very High Very High
antagonist 281 100.00 Very High Very High Very High
substance P 126 100.00 Very High Very High Very High
bradykinin 204 99.98 Very High Very High Very High
corticosteroid 75 99.98 Very High Very High Very High
Kinase C inhibitor 6 99.96 Very High Very High Very High
lidocaine 15 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 5233 100.00 Very High Very High Very High
Cancer 2527 100.00 Very High Very High Very High
Herpes Simplex Virus 490 100.00 Very High Very High Very High
Adhesions 455 100.00 Very High Very High Very High
Necrosis 294 100.00 Very High Very High Very High
Dyspepsia 262 100.00 Very High Very High Very High
Osteoporosis 135 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 80 100.00 Very High Very High Very High
Viral Meningitis 29 100.00 Very High Very High Very High
Infection 1554 99.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Figure 5A shows that ISO photochemical products induced a greater change in IL-8 expression (IL-8 protein induced) compared with clean air control.
Positive_regulation (induced) of Gene_expression (expression) of IL-8
1) Confidence 0.70 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
Previous studies have shown that A549 epithelial cells exposed to O3 concentrations less than those produced in these studies did increase IL-8 production (Jaspers et al. 1997), which would suggest that O3 is the major photochemical product causing the increase in IL-8 production.
Positive_regulation (increase) of Gene_expression (production) of IL-8 in A549
2) Confidence 0.70 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
Figure 5B demonstrates that BD photochemical products induced a significantly greater IL-8 expression compared with BD plus NO alone, which also enhanced IL-8 expression compared with the clean air control.
Positive_regulation (induced) of Gene_expression (expression) of IL-8
3) Confidence 0.70 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
The IL-8 mRNA and protein data indicate that both biogenic ISO and anthropogenic BD, as they react within the atmosphere, generate products that are more potent inducers of IL-8 gene expression than the unreacted volatile organic compounds.
Positive_regulation (inducers) of Gene_expression (expression) of IL-8
4) Confidence 0.70 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
These results indicate that although BD and ISO alone caused similar cytotoxicity and IL-8 responses compared with the air control, their photochemical products significantly enhanced cytotoxicity and IL-8 gene expression.
Positive_regulation (enhanced) of Gene_expression (expression) of IL-8
5) Confidence 0.70 Published 2004 Journal Environ Health Perspect Section Abstract Doc Link PMC1247611 Disease Relevance 0.23 Pain Relevance 0.08
In this study, we examined cytotoxicity and IL-8 gene expression induced by these photochemical gaseous mixtures using A549 cells, a human alveolar type II-like cell line, and differentiated human bronchial cells.
Spec (examined) Positive_regulation (induced) of Gene_expression (expression) of IL-8 in A549
6) Confidence 0.70 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
Because this is not the case, these data indicate that O3 is not the sole inducer of IL-8 protein secretion, but that other photochemical products generated during the reactions of ISO or BD with sunlight are causing the increase in IL-8 production.
Positive_regulation (increase) of Gene_expression (production) of IL-8
7) Confidence 0.70 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
Previous studies have shown that A549 epithelial cells exposed to O3 concentrations less than those produced in these studies did increase IL-8 production (Jaspers et al. 1997), which would suggest that O3 is the major photochemical product causing the increase in IL-8 production.
Positive_regulation (increase) of Gene_expression (production) of IL-8 in A549
8) Confidence 0.70 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
Figure 5A shows that ISO photochemical products induced a greater change in IL-8 expression (IL-8 protein induced) compared with clean air control.
Positive_regulation (induced) of Gene_expression (expression) of IL-8
9) Confidence 0.70 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
In conclusion, magnesium sulfate differentially suppresses endotoxin-stimulated IL-8 production in amniotic and decidual cells in vitro.
Positive_regulation (stimulated) of Gene_expression (production) of IL-8
10) Confidence 0.70 Published 2006 Journal J. Reprod. Immunol. Section Abstract Doc Link 16384605 Disease Relevance 0.18 Pain Relevance 0.09
Magnesium sulfate dose dependently inhibited the endotoxin-stimulated IL-8 production in both decidual and amniotic cells.
Positive_regulation (stimulated) of Gene_expression (production) of IL-8
11) Confidence 0.70 Published 2006 Journal J. Reprod. Immunol. Section Abstract Doc Link 16384605 Disease Relevance 0.21 Pain Relevance 0.11
Endotoxin caused a significant elevation in IL-8 production in both amniotic and decidual cells.
Positive_regulation (elevation) of Gene_expression (production) of IL-8
12) Confidence 0.70 Published 2006 Journal J. Reprod. Immunol. Section Abstract Doc Link 16384605 Disease Relevance 0.22 Pain Relevance 0.11
Moreover, our data showed that the higher percentage of ER-negative tumors were present in patients carrying the IL-8 (-251) A allele which is associated with a higher IL-8 production.
Positive_regulation (higher) of Gene_expression (production) of IL-8 associated with cancer
13) Confidence 0.70 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 1.01 Pain Relevance 0.10
In recent years, several studies have shown that IL-8 and CXCR2 are overexpressed in a range of human cancers including renal, prostate, pancreatic, colon, nasopharyngeal, and gastric cancers [37-41].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of IL-8 in colon associated with cancer and stomach cancer
14) Confidence 0.70 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 0.91 Pain Relevance 0.31
Recently, it has been shown that the ER-negative breast cancer cells overexpressed IL-8.
Positive_regulation (overexpressed) of Neg (negative) Gene_expression (overexpressed) of IL-8 associated with breast cancer
15) Confidence 0.70 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 1.31 Pain Relevance 0.11
Overexpression of IL-8 is associated with increasing tumor stage, disease progression and recurrence in human bladder, prostate, breast, lung, gastric, hepatic cancers, and melanoma [11,14-16,43,50,51].
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of IL-8 in lung associated with liver cancer, cancer, skin cancer, recurrence and disease progression
16) Confidence 0.70 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 1.45 Pain Relevance 0.21
Treatment of amnion cells stimulated by IL-1 beta with cycloheximide resulted in increased IL-8 production, while incubation of IL-1 beta treated amnion cells with actinomycin D resulted in a concentration-dependent decrease in detectable amounts of IL-8.
Positive_regulation (increased) of Gene_expression (production) of IL-8 in amnion
17) Confidence 0.69 Published 1992 Journal J. Cell. Physiol. Section Abstract Doc Link 1522134 Disease Relevance 0.80 Pain Relevance 0.42
Increase of intracellular Ca(2+) resulted in inducing IL-8 gene expression and protein secretion, and addition of EGTA or BAPTA/AM before Ca(2+) stimulation inhibited the induction of IL-8 production.
Positive_regulation (induction) of Gene_expression (production) of IL-8
18) Confidence 0.66 Published 2005 Journal Cytokine Section Abstract Doc Link 16343928 Disease Relevance 0.15 Pain Relevance 0.19
Pretreatment of MAPK inhibitors (PD98059 and SB203580) markedly blocked Ca(2+)-induced IL-8 production from cells, and anti-inflammatory drugs, such as dexamethasone and cyclosporin A, partially inhibited the activation of ERK1/2.
Positive_regulation (induced) of Gene_expression (production) of IL-8 associated with inflammation, cinod and dexamethasone
19) Confidence 0.66 Published 2005 Journal Cytokine Section Abstract Doc Link 16343928 Disease Relevance 0.17 Pain Relevance 0.22
Increase of intracellular Ca(2+) resulted in inducing IL-8 gene expression and protein secretion, and addition of EGTA or BAPTA/AM before Ca(2+) stimulation inhibited the induction of IL-8 production.
Positive_regulation (resulted) of Gene_expression (expression) of IL-8
20) Confidence 0.66 Published 2005 Journal Cytokine Section Abstract Doc Link 16343928 Disease Relevance 0.15 Pain Relevance 0.18

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