INT108371

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.53
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 12
Disease Relevance 3.11
Pain Relevance 5.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spinal cord 4
spinal 2
primary motor cortex 2
neurons 1
thalamus 1
Cnnm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
long-term potentiation 120 99.84 Very High Very High Very High
Locus ceruleus 27 99.84 Very High Very High Very High
anesthesia 23 99.56 Very High Very High Very High
antinociception 9 99.36 Very High Very High Very High
Somatosensory cortex 15 98.76 Very High Very High Very High
midbrain 5 98.24 Very High Very High Very High
Antinociceptive 9 95.72 Very High Very High Very High
Thalamus 5 95.60 Very High Very High Very High
Glutamate 3 95.04 Very High Very High Very High
antagonist 103 92.76 High High
Disease Link Frequency Relevance Heat
Neuropathic Pain 27 98.60 Very High Very High Very High
Nociception 3 93.44 High High
Disease 20 90.20 High High
Urological Neuroanatomy 5 84.28 Quite High
Stroke 15 82.80 Quite High
Pain 8 82.40 Quite High
Tremor 5 77.40 Quite High
Brain Injury 15 76.88 Quite High
Depression 20 52.64 Quite High
Injury 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Electric stimulation of M1 produced equally strong spinal antinociception in neuropathic and control rats.
Positive_regulation (stimulation) of M1 in spinal associated with antinociception and neuropathic pain
1) Confidence 0.53 Published 2010 Journal Exp Brain Res Section Abstract Doc Link 19826796 Disease Relevance 0.67 Pain Relevance 0.96
Influence of electric stimulation of M1 on LC neurons was studied only in the neuropathic group, in which discharge rates of LC neurons were increased by electric M1 stimulation.
Positive_regulation (stimulation) of M1 in neurons associated with locus ceruleus and neuropathic pain
2) Confidence 0.53 Published 2010 Journal Exp Brain Res Section Abstract Doc Link 19826796 Disease Relevance 0.78 Pain Relevance 1.16
The results indicate that stimulation of the rat M1 induces spinal antinociception in neuropathic as well as control conditions.
Positive_regulation (stimulation) of M1 in spinal associated with antinociception and neuropathic pain
3) Confidence 0.36 Published 2010 Journal Exp Brain Res Section Abstract Doc Link 19826796 Disease Relevance 0.71 Pain Relevance 1.05
The levels of m1, m2, m3 and m5 in spinal cord were increased by pretreatment with pirenzepine and the levels of m2, m3 and m4 in spinal cord were increased by pretreatment with scopolamine.
Positive_regulation (increased) of m1 in spinal cord
4) Confidence 0.11 Published 2002 Journal Yao Xue Xue Bao Section Body Doc Link 12567774 Disease Relevance 0 Pain Relevance 0
RESULTS: The mRNA level of m1, m2, m3, m4 and m5 in spinal cord and m1 and m2 in brainstem were increased significantly during morphine dependence, and the levels of m1, m2, m3 and m4 in spinal cord and m1 in brainstem were decreased 1 h after the injection of naloxone (4 mg.kg-1, i.p.) in morphine dependent rats.
Positive_regulation (increased) of m1 in spinal cord
5) Confidence 0.11 Published 2002 Journal Yao Xue Xue Bao Section Body Doc Link 12567774 Disease Relevance 0 Pain Relevance 0
RESULTS: The mRNA level of m1, m2, m3, m4 and m5 in spinal cord and m1 and m2 in brainstem were increased significantly during morphine dependence, and the levels of m1, m2, m3 and m4 in spinal cord and m1 in brainstem were decreased 1 h after the injection of naloxone (4 mg.kg-1, i.p.) in morphine dependent rats.
Positive_regulation (increased) of m1 in spinal cord
6) Confidence 0.11 Published 2002 Journal Yao Xue Xue Bao Section Body Doc Link 12567774 Disease Relevance 0 Pain Relevance 0
RESULTS: The mRNA level of m1, m2, m3, m4 and m5 in spinal cord and m1 and m2 in brainstem were increased significantly during morphine dependence, and the levels of m1, m2, m3 and m4 in spinal cord and m1 in brainstem were decreased 1 h after the injection of naloxone (4 mg.kg-1, i.p.) in morphine dependent rats.
Positive_regulation (increased) of m1 in spinal cord
7) Confidence 0.09 Published 2002 Journal Yao Xue Xue Bao Section Body Doc Link 12567774 Disease Relevance 0 Pain Relevance 0
Asanuma and colleagues showed that LTP can be induced in M1 by tetanic stimulation of the somatosensory cortex or by associative stimulation of somatosensory cortex and thalamus [34].
Positive_regulation (induced) of M1 in thalamus associated with somatosensory cortex, thalamus and long-term potentiation
8) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2738964 Disease Relevance 0 Pain Relevance 0.63
We found that dopaminergic signaling in primary motor cortex (M1) is necessary for normal motor skill learning and synaptic plasticity within M1, but not for the execution of a learned task or for synaptic transmission.
Positive_regulation (necessary) of M1 in primary motor cortex
9) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2738964 Disease Relevance 0 Pain Relevance 0.52
Here, we present findings suggesting that these phenomena are explained by dopaminergic transmission in primary motor cortex (M1) that enables M1 synaptic plasticity.
Positive_regulation (enables) of M1 in primary motor cortex
10) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2738964 Disease Relevance 0.35 Pain Relevance 0.30
Considering that these patients show reduced M1 plasticity [52] and deficits in skill [8] and procedural learning [53], our findings provide a potential mechanism for these deficits, that is the degeneration of M1 dopaminergic signaling.
Positive_regulation (degeneration) of M1
11) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2738964 Disease Relevance 0.59 Pain Relevance 0.35
Asanuma and colleagues showed that LTP can be induced in M1 by tetanic stimulation of the somatosensory cortex or by associative stimulation of somatosensory cortex and thalamus [34].
Positive_regulation (induced) of M1 in cortex associated with somatosensory cortex, thalamus and long-term potentiation
12) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2738964 Disease Relevance 0 Pain Relevance 0.63

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox