INT10838

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Context Info
Confidence 0.70
First Reported 1992
Last Reported 2011
Negated 9
Speculated 5
Reported most in Abstract
Documents 381
Total Number 388
Disease Relevance 295.51
Pain Relevance 101.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL8) extracellular space (IL8) extracellular region (IL8)
intracellular (IL8)
Anatomy Link Frequency
neutrophils 26
plasma 14
lung 10
epithelial cells 10
endothelial cells 8
IL8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 6371 100.00 Very High Very High Very High
cytokine 5050 100.00 Very High Very High Very High
chemokine 2246 100.00 Very High Very High Very High
Inflammatory mediators 416 100.00 Very High Very High Very High
antagonist 300 100.00 Very High Very High Very High
substance P 182 100.00 Very High Very High Very High
ischemia 106 99.98 Very High Very High Very High
Arthritis 956 99.92 Very High Very High Very High
Inflammatory response 719 99.92 Very High Very High Very High
endometriosis 527 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 7444 100.00 Very High Very High Very High
Cancer 4203 100.00 Very High Very High Very High
Pulmonary Disease 2054 100.00 Very High Very High Very High
Adenocarcinoma 1282 100.00 Very High Very High Very High
Stress 726 100.00 Very High Very High Very High
Adhesions 465 100.00 Very High Very High Very High
Necrosis 373 100.00 Very High Very High Very High
Obesity 234 100.00 Very High Very High Very High
Osteoporosis 100 100.00 Very High Very High Very High
Cv Unclassified Under Development 90 99.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lipopolysaccharide increased extracellular accumulation of interleukin-8, which was suppressed by both propofol (P = 0.025) and midazolam (P = 0.028).
Positive_regulation (accumulation) of interleukin-8 associated with versed
1) Confidence 0.70 Published 1998 Journal Anesth. Analg. Section Abstract Doc Link 9620522 Disease Relevance 0.13 Pain Relevance 0.25
However, intracellular IL-8 increased with exposure to lipopolysaccharide (P = 0.028) and remained increased with both anesthetics.
Positive_regulation (increased) of IL-8
2) Confidence 0.70 Published 1998 Journal Anesth. Analg. Section Abstract Doc Link 9620522 Disease Relevance 0.14 Pain Relevance 0.31
Northern blot analysis also revealed increased IL-8 mRNA levels in the presence of both midazolam and propofol, which was confirmed by molecular imaging.
Positive_regulation (increased) of IL-8 associated with versed and imagery
3) Confidence 0.70 Published 1998 Journal Anesth. Analg. Section Abstract Doc Link 9620522 Disease Relevance 0.14 Pain Relevance 0.32
CONCLUSIONS: This study demonstrates that IL-8 is produced and accumulated in pulp inflammation and may play a role in the occurrence and development of human pulpitis.


Positive_regulation (accumulated) of IL-8
4) Confidence 0.70 Published 2000 Journal Chin J Dent Res Section Body Doc Link 11314344 Disease Relevance 0.08 Pain Relevance 0
In the present study, the comparison of genotype frequencies of IL-8 for breast carcinoma patients and control subjects indicates an increase of IL-8 (-251) TA and AA genotypes.
Positive_regulation (increase) of IL-8 associated with breast cancer
5) Confidence 0.70 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 0.66 Pain Relevance 0.03
There is now convincing evidence that these correlations between IL-8 A allele and cancer risk result from an increased level of IL-8 protein, which may have an impact on cancer development and progression via the regulation of immune response and pathways of tumor angiogenesis.
Positive_regulation (increased) of IL-8 associated with cancer
6) Confidence 0.70 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 1.36 Pain Relevance 0.14
It has been reported that interleukin-8 (IL-8) is secreted from the placental and decidual tissues and that IL-8 levels in the amniotic fluids are significantly elevated by chorioamnionitis or labor pain.
Positive_regulation (elevated) of IL-8 in amniotic fluids associated with chorioamnionitis and pain labor
7) Confidence 0.69 Published 1994 Journal J. Reprod. Immunol. Section Abstract Doc Link 7738906 Disease Relevance 0.25 Pain Relevance 0.10
Northern blot analysis of cultured amnion cells stimulated with IL-1 beta demonstrated a rapid increase in IL-8 mRNA which peaked at 2-4 hr.
Positive_regulation (increase) of IL-8 in amnion
8) Confidence 0.69 Published 1992 Journal J. Cell. Physiol. Section Abstract Doc Link 1522134 Disease Relevance 0.73 Pain Relevance 0.40
RESULTS: Significantly increased levels of cytokines (IL-1alpha, IL-1beta, IL-6, IL-10, IL12p70) and chemokines (CCL1, CCL3, CCL4, CCL17, CCL22, CXCL8/IL-8) were observed in seminal plasmas from patients with CP/CPPS or BPH.
Positive_regulation (increased) of CXCL8 in plasmas
9) Confidence 0.67 Published 2007 Journal Eur. Urol. Section Body Doc Link 16905241 Disease Relevance 0.38 Pain Relevance 0
The activation of NF-kappaB by rhTNF-alpha was associated with 27, eight, ten and sevenfold increases in the TNF-alpha, IL-1beta, IL-6 and IL-8 transcripts, respectively.
Positive_regulation (increases) of IL-8
10) Confidence 0.67 Published 2003 Journal Urol. Res. Section Abstract Doc Link 14574533 Disease Relevance 0.68 Pain Relevance 0.62
The concentrations of IL-8 in CSF were increased in 12 out of 39 patients, and these increased levels of IL-8 correlated to a short duration of pain and to more pronounced herniation (extrusion or sequestration).
Positive_regulation (increased) of IL-8 in CSF associated with pain
11) Confidence 0.66 Published 2002 Journal Eur Spine J Section Abstract Doc Link 11931066 Disease Relevance 0.72 Pain Relevance 0.68
The finding that most of the patients with increased concentrations of IL-8 in CSF had an extrusion or a sequestration may suggest that the increase in IL-8 is related to mechanical nerve root compression, but may also indicate a biochemical effect exerted by the herniated disc on the surrounding tissue.
Positive_regulation (increase) of IL-8 in nerve associated with nerve root compression and intervertebral disk displacement
12) Confidence 0.66 Published 2002 Journal Eur Spine J Section Abstract Doc Link 11931066 Disease Relevance 0.69 Pain Relevance 0.51
NF-kappaB inhibitors blocked the ability of Ca(2+) to induce IL-8 production, and the activation of NF-kappaB was required for intracellular Ca(2+)-induced up-regulation of IL-8.
Positive_regulation (up-regulation) of IL-8
13) Confidence 0.66 Published 2005 Journal Cytokine Section Abstract Doc Link 16343928 Disease Relevance 0.14 Pain Relevance 0.18
The inhibitory effect of NHE inhibition on IL-8 was associated with a decrease in IL-8 mRNA accumulation.
Positive_regulation (accumulation) of IL-8
14) Confidence 0.63 Published 2002 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12065299 Disease Relevance 0.88 Pain Relevance 0.33
Interleukin-8 is increased in gingival crevicular fluid from patients with acute pulpitis.
Positive_regulation (increased) of Interleukin-8 associated with pulpitis
15) Confidence 0.63 Published 2008 Journal J Endod Section Title Doc Link 18215670 Disease Relevance 0.49 Pain Relevance 0.40
It is interesting to note that in this example, group A seems to be the more appropriate control, because an increase in IL8 mRNA levels from mild (A1F1) to advanced disease (A2F3) is observed, suggesting a model with IL8 activation during fibrogenesis.


Positive_regulation (activation) of IL8 associated with fibrosis and disease
16) Confidence 0.63 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 0.94 Pain Relevance 0.04
The immunosuppressant cyclosporin A (50 microM) partially reduced the ischemia-stimulated IL-8 and MCP-1 secretion by HCEC.
Positive_regulation (stimulated) of IL-8 in HCEC associated with ischemia
17) Confidence 0.59 Published 2000 Journal Acta Neurochir. Suppl. Section Abstract Doc Link 11450070 Disease Relevance 1.13 Pain Relevance 0.60
In this study, we show that human cere-bromicrovascular endothelial cells (HCEC) subjected to a 4 h in vitro ischemia (hypoxia + glucose deprivation) followed by a 4-24 h recovery express elevated levels of ICAM-1, IL-8, and MCP-1 mRNAs (semi-quantitative RT-PCR) and secrete increased amounts of the immunoreactive chemokines IL-8 and MCP-1 (ELISA).
Positive_regulation (increased) of IL-8 in HCEC associated with chemokine, hypoxia and ischemia
18) Confidence 0.59 Published 2000 Journal Acta Neurochir. Suppl. Section Abstract Doc Link 11450070 Disease Relevance 1.10 Pain Relevance 0.48
BAL IL-8 levels in the low VT group remained stable (96 (49 to 553) pg/ml vs. 82 (32 to 500) pg/ml, P = 0.84) but increased in the high VT group (41(10 to 210) pg/ml vs. 328 (50 to 1,000) pg/ml, P = 0.01) without differences between groups after 12 hours (P = 0.27).
Positive_regulation (increased) of IL-8
19) Confidence 0.57 Published 2010 Journal Crit Care Section Body Doc Link PMC2887148 Disease Relevance 0 Pain Relevance 0.09
Pyocyanin alone produced no increase in IL-8 mRNA and release.
Neg (no) Positive_regulation (increase) of IL-8
20) Confidence 0.56 Published 2006 Journal Respir Med Section Abstract Doc Link 16448811 Disease Relevance 0.16 Pain Relevance 0.21

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