INT108384

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Context Info
Confidence 0.39
First Reported 2002
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 28
Total Number 29
Disease Relevance 10.73
Pain Relevance 9.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk1) plasma membrane (Ntrk1) kinase activity (Ntrk1)
cytoplasm (Ntrk1)
Anatomy Link Frequency
neurons 3
cholinergic neurons 2
sensory neurons 1
blood 1
medulla 1
Ntrk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 7 100.00 Very High Very High Very High
Nerve growth factor 307 99.96 Very High Very High Very High
substance P 18 99.78 Very High Very High Very High
Osteoarthritis 440 99.48 Very High Very High Very High
Pain 129 99.48 Very High Very High Very High
medulla 6 99.24 Very High Very High Very High
Congenital analgesia 4 99.20 Very High Very High Very High
Neurotransmitter 6 98.72 Very High Very High Very High
unmyelinated 4 98.04 Very High Very High Very High
pruritus 59 97.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Syndrome 4 99.60 Very High Very High Very High
Frailty 482 99.48 Very High Very High Very High
Postoperative Hemorrhage 5 99.36 Very High Very High Very High
Repression 7 99.30 Very High Very High Very High
Pain 129 98.86 Very High Very High Very High
Colitis 5 98.64 Very High Very High Very High
Pruritus 78 97.48 Very High Very High Very High
Mental Disorders 26 97.12 Very High Very High Very High
Psoriasis 60 96.12 Very High Very High Very High
Obesity 83 95.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This compound binds TrkA, but not TrkB or TrkC, and causes receptor dimerization and phosphorylation.
TrkA Binding (binds) of
1) Confidence 0.39 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.52 Pain Relevance 0.12
On the other hand, Runx1 is essential for the late repression of trkA and induction of Ret when TrkA+ and Ret+ neurons segregate (Figure 1b) [34].
TrkA Binding (segregate) of in neurons associated with repression
2) Confidence 0.29 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.60 Pain Relevance 0.28
All neurotrophins bind p75NTR with similar affinity (Kd~10-9 M), but binding to the Trk receptors is more selective.
Trk Binding (binding) of
3) Confidence 0.29 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.17 Pain Relevance 0.27
NT-6 and -7 are more closely related to NGF than the other neurotrophins and bind TrkA [1].
TrkA Binding (bind) of associated with nerve growth factor
4) Confidence 0.29 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.22 Pain Relevance 0.29
Overall, the surface topology (shape and electrostatic potential) of the combining site is consistent with the binding data on TrkA ECD serial deletions mutants.
TrkA Binding (binding) of
5) Confidence 0.28 Published 2005 Journal Proteins Section Abstract Doc Link 15625712 Disease Relevance 0 Pain Relevance 0.08
Necdin interacted with both TrkA and p75 to facilitate the association between these receptors.
TrkA Binding (interacted) of
6) Confidence 0.27 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16049186 Disease Relevance 0.35 Pain Relevance 0.27
NGF is thought to excite and sensitize sensory neurons by binding to its cognate receptor TrkA which is expressed by a subpopulation of mostly unmyelinated and thinly myelinated sensory neurons [18].
TrkA Binding (binding) of in sensory neurons associated with nerve growth factor and unmyelinated
7) Confidence 0.27 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004846 Disease Relevance 0.78 Pain Relevance 1.19
In contrast, it did not bind to TrkA at all, indicating it specifically associates with the extracellular domain of TrkB receptor (Figure 3A).
TrkA Neg (not) Binding (bind) of
8) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0 Pain Relevance 0
Most labeled neurons were CGRP (79%), tyrosine kinase A (trkA) (84%) immunoreactive, but only a small minority bind IB4 (14%).
trkA Binding (bind) of in neurons
9) Confidence 0.24 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15205116 Disease Relevance 0.54 Pain Relevance 0.54
These effects are mediated by binding to high-affinity tyrosine kinase (trk) receptors (generally promoting neuron survival and differentiation) or to the low-affinity panneurotrophin receptor p75 (generally mediating apoptosis and death).
trk Binding (binding) of in neuron associated with apoptosis and death
10) Confidence 0.23 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440791 Disease Relevance 0.63 Pain Relevance 0.41
TrkA mutant mice are insensitive to painful stimuli and mutations in TRKA are associated with the syndrome "Congenital insensitivity to pain" in humans [7].
TRKA Binding (associated) of associated with pain, congenital analgesia and syndrome
11) Confidence 0.21 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0.20 Pain Relevance 0.59
On the other hand, both TRK-820 and (-)-U50,488H produced small but significant increases of [35S]GTPgammaS binding to the mouse pons/medulla membrane.
TRK-820 Binding (binding) of in medulla associated with medulla
12) Confidence 0.14 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12568913 Disease Relevance 0 Pain Relevance 0.84
When exploring the association with TKR, we found a significant OR in some cases for other occupations than male farmers, but only the farmers differed consistently from the other work classes.
TKR Binding (association) of
13) Confidence 0.12 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911890 Disease Relevance 0.17 Pain Relevance 0.08
We found a strong association for TKR in farmers with OR 5.1 (95% CI 2.1 to 12.4).
TKR Binding (association) of
14) Confidence 0.12 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911890 Disease Relevance 0.37 Pain Relevance 0.07
To the best of our knowledge this is the first population-based study to suggest an association with both TKR and THR and farming in the same sample.
TKR Binding (association) of
15) Confidence 0.11 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911890 Disease Relevance 0.32 Pain Relevance 0.16
This might in some part explain the association between TKR/THR and farming.
TKR Spec (might) Binding (association) of
16) Confidence 0.10 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911890 Disease Relevance 0.29 Pain Relevance 0.14
Since the patients belong to the population of Bedouins in the south of Israel where congenital insensitivity to pain with anhydrosis (CIPA) is prevalent we firstly excluded linkage to the TrkA gene, assuming homozygosity in which the two alleles are identical by descent, by the use of microsatellite markers adjacent to the gene (data not shown).
TrkA Binding (linkage) of associated with pain and congenital analgesia
17) Confidence 0.09 Published 2010 Journal Human Mutation Section Body Doc Link PMC2966863 Disease Relevance 0.18 Pain Relevance 0.25
This suggests that male fishermen are associated with having TKR.
TKR Binding (associated) of
18) Confidence 0.08 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911890 Disease Relevance 0.12 Pain Relevance 0.06
The cases in that study were drawn from the entire Icelandic population representing all patients that had received a TKR or THR due to OA, and were alive and living in Iceland in 1998.
TKR Binding (received) of associated with osteoarthritis
19) Confidence 0.08 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911890 Disease Relevance 0.52 Pain Relevance 0.26
We found no significant association for other professions, other than an increased likelihood for TKR due to knee OA for fishermen, when compared to more sedentary occupations.
TKR Neg (no) Binding (association) of in knee associated with osteoarthritis
20) Confidence 0.08 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911890 Disease Relevance 0.42 Pain Relevance 0.18

General Comments

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