INT108386

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Context Info
Confidence 0.27
First Reported 2002
Last Reported 2003
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.56
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (IL1B, MMP1) aging (IL1B) cell-cell signaling (IL1B)
cytosol (IL1B) extracellular space (IL1B) signal transduction (IL1B)
Anatomy Link Frequency
tendon cells 1
IL1B (Homo sapiens)
MMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 14 100.00 Very High Very High Very High
cOX1 2 96.92 Very High Very High Very High
Lasting pain 2 94.92 High High
cINOD 2 93.08 High High
Inflammatory mediators 1 89.16 High High
metalloproteinase 14 88.36 High High
Inflammation 23 85.44 High High
cytokine 19 83.96 Quite High
Inflammatory response 5 82.36 Quite High
chemokine 11 17.28 Low Low
Disease Link Frequency Relevance Heat
Cumulative Trauma Disorders 2 97.36 Very High Very High Very High
Injury 4 96.52 Very High Very High Very High
Pain 3 94.92 High High
INFLAMMATION 29 92.88 High High
Adhesions 2 67.40 Quite High
Death 6 63.48 Quite High
Hemorrhage 2 57.76 Quite High
Cancer 4 53.40 Quite High
Disease 8 5.00 Very Low Very Low Very Low
Arthritis 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-1 beta induces COX2, MMP-1, -3 and -13, ADAMTS-4, IL-1 beta and IL-6 in human tendon cells.
IL-1 Positive_regulation (induces) of MMP-1 in tendon cells associated with cox2
1) Confidence 0.27 Published 2003 Journal J. Orthop. Res. Section Title Doc Link 12568957 Disease Relevance 0.62 Pain Relevance 0.58
IL-1 beta (1 nM) induced mRNAs for cyclooxygenase 2 (COX2), MMP-1, -3, -13 and aggrecanase-1 as well as IL-1 beta and IL-6, whereas mRNAs for COX1 and MMP-2 were expressed constitutively.
IL-1 Positive_regulation (induced) of MMP-1 associated with cox2 and cox1
2) Confidence 0.27 Published 2003 Journal J. Orthop. Res. Section Abstract Doc Link 12568957 Disease Relevance 0.56 Pain Relevance 0.65
The production of PGE2, MMP-1, IL-8, IL-6, RANTES and IP-10 induced by hTWEAK (but not the production induced by TNF and IL-1?)
IL-1 Positive_regulation (induced) of MMP-1
3) Confidence 0.03 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83846 Disease Relevance 0.38 Pain Relevance 0.04

General Comments

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