INT108389

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Context Info
Confidence 0.51
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.19
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL1B, ADAMTS4) extracellular region (IL1B, ADAMTS4) aging (IL1B)
cell-cell signaling (IL1B) cytosol (IL1B) signal transduction (IL1B)
Anatomy Link Frequency
tendon cells 1
IL1B (Homo sapiens)
ADAMTS4 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 12 100.00 Very High Very High Very High
cOX1 2 98.00 Very High Very High Very High
Lasting pain 2 95.80 Very High Very High Very High
cINOD 2 93.96 High High
metalloproteinase 8 88.36 High High
Inflammation 4 86.32 High High
cytokine 8 83.96 Quite High
Inflammatory response 2 83.24 Quite High
Disease Link Frequency Relevance Heat
Cumulative Trauma Disorders 2 98.24 Very High Very High Very High
Injury 4 97.40 Very High Very High Very High
Pain 2 95.80 Very High Very High Very High
INFLAMMATION 8 93.76 High High
Hemorrhage 2 59.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-1 beta induces COX2, MMP-1, -3 and -13, ADAMTS-4, IL-1 beta and IL-6 in human tendon cells.
IL-1 Positive_regulation (induces) of ADAMTS-4 in tendon cells associated with cox2
1) Confidence 0.51 Published 2003 Journal J. Orthop. Res. Section Title Doc Link 12568957 Disease Relevance 0.62 Pain Relevance 0.59
IL-1 beta (1 nM) induced mRNAs for cyclooxygenase 2 (COX2), MMP-1, -3, -13 and aggrecanase-1 as well as IL-1 beta and IL-6, whereas mRNAs for COX1 and MMP-2 were expressed constitutively.
IL-1 Positive_regulation (induced) of aggrecanase-1 associated with cox2 and cox1
2) Confidence 0.26 Published 2003 Journal J. Orthop. Res. Section Abstract Doc Link 12568957 Disease Relevance 0.56 Pain Relevance 0.65

General Comments

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