INT108395

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.50
First Reported 2003
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 1.26
Pain Relevance 2.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) plasma membrane (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
bladder 4
Trpv1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 204 100.00 Very High Very High Very High
agonist 9 99.96 Very High Very High Very High
Cannabinoid receptor 4 99.60 Very High Very High Very High
dorsal root ganglion 2 98.88 Very High Very High Very High
adenocard 2 97.36 Very High Very High Very High
Anterior cingulate cortex 18 96.80 Very High Very High Very High
Inflammation 11 95.96 Very High Very High Very High
IPN 5 86.36 High High
Pain 40 80.68 Quite High
antagonist 16 77.68 Quite High
Disease Link Frequency Relevance Heat
Cystitis 2 100.00 Very High Very High Very High
Ganglion Cysts 2 98.88 Very High Very High Very High
INFLAMMATION 12 95.96 Very High Very High Very High
Pain 36 80.68 Quite High
Hyperalgesia 14 75.00 Quite High
Acidosis 3 63.56 Quite High
Inflammatory Pain 5 62.68 Quite High
Cv Unclassified Under Development 1 40.24 Quite Low
Infection 1 39.12 Quite Low
Targeted Disruption 10 12.68 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TRPV1 Transient receptor potential vanilloid-1
Positive_regulation (potential) of TRPV1 Binding (receptor) of
1) Confidence 0.50 Published 2006 Journal Mol Pain Section Body Doc Link PMC1647269 Disease Relevance 0.26 Pain Relevance 0.40
Up-regulation of protease activated receptors in bladder after cyclophosphamide induced cystitis and colocalization with capsaicin receptor (VR1) in bladder nerve fibers.
Positive_regulation (induced) of VR1 Binding (colocalization) of in bladder associated with qutenza and cystitis
2) Confidence 0.50 Published 2005 Journal J. Urol. Section Title Doc Link 15643279 Disease Relevance 0.20 Pain Relevance 0.28
Up-regulation of protease activated receptors in bladder after cyclophosphamide induced cystitis and colocalization with capsaicin receptor (VR1) in bladder nerve fibers.
Positive_regulation (induced) of capsaicin receptor Binding (colocalization) of in bladder associated with qutenza and cystitis
3) Confidence 0.50 Published 2005 Journal J. Urol. Section Title Doc Link 15643279 Disease Relevance 0.20 Pain Relevance 0.28
TRPV1 Transient receptor potential vanilloid-1
Positive_regulation (potential) of vanilloid-1 Binding (receptor) of
4) Confidence 0.44 Published 2006 Journal Mol Pain Section Body Doc Link PMC1647269 Disease Relevance 0.26 Pain Relevance 0.40
Analysis of the activity of six additional synthetic and potentially endogenous N-acyldopamine indicated the requirement of a long unsaturated fatty acid chain for an optimal functional interaction with VR1 receptors.
Positive_regulation (requirement) of VR1 Binding (interaction) of
5) Confidence 0.42 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12569099 Disease Relevance 0.22 Pain Relevance 0.49
Indeed, multiple mutagenesis studies have shown that distinct intracellular regions are necessary for the binding of the exogenous TRPV1 agonist, capsaicin [4-6] although an extracellular site may also contribute to capsaicin binding [7].
Positive_regulation (necessary) of exogenous TRPV1 Binding (binding) of associated with qutenza and agonist
6) Confidence 0.41 Published 2005 Journal Mol Pain Section Body Doc Link PMC1266034 Disease Relevance 0.13 Pain Relevance 0.54

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox