INT108402

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Context Info
Confidence 0.43
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 5.99
Pain Relevance 1.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (FAAH) cytoplasm (FAAH)
Anatomy Link Frequency
plasma 4
AT-1 2
subcutaneous adipose tissue 2
FAAH (Homo sapiens)
Pain Link Frequency Relevance Heat
Endocannabinoid 127 99.54 Very High Very High Very High
Cannabinoid 17 97.76 Very High Very High Very High
agonist 9 92.52 High High
Cannabinoid receptor 23 89.76 High High
qutenza 4 80.32 Quite High
Inflammation 10 77.84 Quite High
abdominal pain 3 70.80 Quite High
nud 1 68.80 Quite High
antagonist 1 48.44 Quite Low
cytokine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 411 99.70 Very High Very High Very High
Breast Cancer 1 99.52 Very High Very High Very High
Endometriosis (extended) 3 98.38 Very High Very High Very High
Diabetes Mellitus 87 90.00 High High
Prostate Cancer 51 86.56 High High
Gastrointestinal Disease 5 85.76 High High
Constipation 1 78.80 Quite High
INFLAMMATION 10 77.84 Quite High
Diarrhoea 1 76.56 Quite High
Cancer 78 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A single nucleotide polymorphism in the human FAAH gene (C385A) reduces FAAH expression.
Negative_regulation (reduces) of Gene_expression (expression) of FAAH
1) Confidence 0.43 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17962356 Disease Relevance 0.61 Pain Relevance 0.35
In our hands, the hydrolysis of 2-AG by intact PC-3 cells is only marginally inhibited by the selective FAAH inhibitor URB597, and in the case of R3327 AT-1 cells, no inhibition is seen [47].
Negative_regulation (inhibitor) of Gene_expression (selective) of FAAH in AT-1
2) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0.33 Pain Relevance 0.07
Indeed, long-term treatment of human breast cancer cells (HBCCs) with PEA downregulates the expression of the enzyme responsible for AEA degradation, the fatty acid amide hydrolase, thereby leading to an enhancement of AEA-induced, and cannabinoid CB1 receptor-mediated, cytostatic effect on HBCCs.
Negative_regulation (downregulates) of Gene_expression (expression) of fatty acid amide hydrolase associated with cannabinoid and breast cancer
3) Confidence 0.33 Published 2002 Journal Fundam Clin Pharmacol Section Abstract Doc Link 12570018 Disease Relevance 0.25 Pain Relevance 0.41
As opposed to obese rodents [13], reduced levels of FAAH expression have been reported for obese subjects also in the subcutaneous adipose tissue (SAT) [9,16,17], where, instead, there seems to be no elevation of endocannabinoid levels [3].
Negative_regulation (reduced) of Gene_expression (expression) of FAAH in subcutaneous adipose tissue associated with endocannabinoid and obesity
4) Confidence 0.24 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2868848 Disease Relevance 1.88 Pain Relevance 0.22
However, in viscerally obese men, only increased plasma 2-AG levels correlated with decreased FAAH mRNA expression in the SAT [10].
Negative_regulation (decreased) of Gene_expression (expression) of FAAH mRNA in plasma associated with obesity
5) Confidence 0.24 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2868848 Disease Relevance 1.32 Pain Relevance 0.17
A previous study carried out in post-menopausal obese women showed that increased plasma endocannabinoids levels correlate with decreased FAAH mRNA expression in the SAT [9], which, in turn, should result in increased SAT endocannabinoid levels.
Negative_regulation (decreased) of Gene_expression (expression) of FAAH mRNA in plasma associated with endocannabinoid, endometriosis (extended) and obesity
6) Confidence 0.17 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2868848 Disease Relevance 1.44 Pain Relevance 0.17

General Comments

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