INT108403

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Context Info
Confidence 0.89
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 2.50
Pain Relevance 2.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (FAAH) cytoplasm (FAAH)
Anatomy Link Frequency
colon 1
FAAH (Homo sapiens)
Pain Link Frequency Relevance Heat
Endocannabinoid 49 100.00 Very High Very High Very High
Cannabinoid 32 99.98 Very High Very High Very High
Inflammation 39 98.68 Very High Very High Very High
Cannabinoid receptor 10 96.86 Very High Very High Very High
Pain 5 94.64 High High
agonist 10 88.96 High High
addiction 2 88.96 High High
anesthesia 2 87.68 High High
Lasting pain 2 87.52 High High
depression 2 86.40 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 37 98.68 Very High Very High Very High
Breast Cancer 1 98.26 Very High Very High Very High
Nociception 2 96.32 Very High Very High Very High
Pain 7 94.64 High High
Inflammatory Bowel Disease 54 93.36 High High
Vomiting 3 92.96 High High
Disease 14 88.08 High High
Depression 2 86.40 High High
Anxiety Disorder 2 85.20 High High
Necrosis 2 81.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fatty acid amide hydrolase (FAAH) is the enzyme responsible for the rapid degradation of fatty acid amides such as the endocannabinoid anandamide.
Protein_catabolism (degradation) of Fatty acid amide hydrolase associated with endocannabinoid
1) Confidence 0.89 Published 2007 Journal J. Neurosci. Methods Section Abstract Doc Link 17083980 Disease Relevance 0.26 Pain Relevance 0.22
Fatty acid amide hydrolase (FAAH) is the enzyme responsible for the rapid degradation of fatty acid amides such as the endocannabinoid anandamide.
Protein_catabolism (degradation) of FAAH associated with endocannabinoid
2) Confidence 0.89 Published 2007 Journal J. Neurosci. Methods Section Abstract Doc Link 17083980 Disease Relevance 0.26 Pain Relevance 0.22
They are rapidly degraded by the fatty acid amide hydrolase (FAAH).
Protein_catabolism (degraded) of fatty acid amide hydrolase
3) Confidence 0.88 Published 2007 Journal Prostaglandins Other Lipid Mediat. Section Abstract Doc Link 17991615 Disease Relevance 0.38 Pain Relevance 0.28
They are rapidly degraded by the fatty acid amide hydrolase (FAAH).
Protein_catabolism (degraded) of FAAH
4) Confidence 0.88 Published 2007 Journal Prostaglandins Other Lipid Mediat. Section Abstract Doc Link 17991615 Disease Relevance 0.38 Pain Relevance 0.28
Indeed, long-term treatment of human breast cancer cells (HBCCs) with PEA downregulates the expression of the enzyme responsible for AEA degradation, the fatty acid amide hydrolase, thereby leading to an enhancement of AEA-induced, and cannabinoid CB1 receptor-mediated, cytostatic effect on HBCCs.
Protein_catabolism (degradation) of fatty acid amide hydrolase associated with cannabinoid and breast cancer
5) Confidence 0.77 Published 2002 Journal Fundam Clin Pharmacol Section Abstract Doc Link 12570018 Disease Relevance 0.25 Pain Relevance 0.40
These data suggest a dysregulated AEA tone in the colon of these patients, in agreement with previous findings.[20], [25] However, we observed low NAPE-PLD expression, mainly in moderate and severe-scored pancolitis patients, and no changes in the AEA-degrading enzyme FAAH, suggesting a decrease of AEA levels, as deduced by the NAPE-PLD/FAAH ratio, while D-Argenio et al. found high AEA levels in biopsy samples of colons from untreated UC patients.[25] This discrepancy may be explained by the fact that NAPE-PLD is not the only source for AEA, as others enzymes are also capable of generating AEA from NAPE, such as ?
Protein_catabolism (degrading) of FAAH in colon associated with inflammatory bowel disease
6) Confidence 0.54 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731878 Disease Relevance 0.18 Pain Relevance 0.23
The aim of the present study is to analyse, by immunocytochemistry, the expression of components of the endocannabinoid system such as cannabinoid CB1 and CB2 receptors and the enzymes involved in cannabinoid degradation (FAAH and MAGL) and biosynthesis (DAGL?
Protein_catabolism (degradation) of FAAH associated with endocannabinoid and cannabinoid
7) Confidence 0.54 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731878 Disease Relevance 0.60 Pain Relevance 0.53
BACKGROUND: The endocannabinoid system includes G-protein-coupled cannabinoid receptors, the endocannabinoids N-arachidonoylethanolamine (anandamide) and 2-arachidonoylglycerol, and multiple enzymes involved in the biosynthesis and degradation of endocannabinoids, including the anandamide metabolizing enzyme fatty acid amide hydrolase.
Protein_catabolism (degradation) of acid amide hydrolase associated with endocannabinoid and cannabinoid receptor
8) Confidence 0.48 Published 2006 Journal Anesthesiology Section Abstract Doc Link 16436846 Disease Relevance 0.19 Pain Relevance 0.55
We performed our experiments in HEK-293 cells overexpressing the recombinant TRPV1 protein (TRPV1-HEK-293 cells), which also possess low levels of expression of the AEA-degrading enzyme, fatty acid amide hydrolase (FAAH) [20], [21].
Protein_catabolism (degrading) of fatty acid amide hydrolase
9) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858646 Disease Relevance 0 Pain Relevance 0.05

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