INT108405

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Context Info
Confidence 0.78
First Reported 2002
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 48
Total Number 51
Disease Relevance 28.22
Pain Relevance 9.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (FAAH) cytoplasm (FAAH)
Anatomy Link Frequency
PC-3 4
osteoclasts 3
plasma 2
VAT 2
stroma 1
FAAH (Homo sapiens)
Pain Link Frequency Relevance Heat
Endocannabinoid 778 100.00 Very High Very High Very High
Cannabinoid 286 100.00 Very High Very High Very High
Cannabinoid receptor 134 100.00 Very High Very High Very High
Osteoarthritis 178 98.84 Very High Very High Very High
rheumatoid arthritis 198 98.56 Very High Very High Very High
Pain 42 96.88 Very High Very High Very High
cytokine 114 95.80 Very High Very High Very High
depression 2 95.76 Very High Very High Very High
palliative 18 92.56 High High
agonist 51 92.20 High High
Disease Link Frequency Relevance Heat
Cancer 1484 100.00 Very High Very High Very High
Disease 591 100.00 Very High Very High Very High
Obesity 836 99.68 Very High Very High Very High
Benign Prostatic Hypertrophy 18 99.66 Very High Very High Very High
Breast Cancer 1 99.16 Very High Very High Very High
Frailty 180 98.84 Very High Very High Very High
Rheumatoid Arthritis 198 98.56 Very High Very High Very High
Prostate Cancer 960 98.28 Very High Very High Very High
Endometriosis (extended) 6 98.18 Very High Very High Very High
Ganglion Cysts 28 98.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A single nucleotide polymorphism in the human FAAH gene (C385A) reduces FAAH expression.
Gene_expression (expression) of FAAH
1) Confidence 0.78 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17962356 Disease Relevance 0.61 Pain Relevance 0.35
Intriguingly, plants lack CB receptors and do not synthesize endocannabinoids, but express FAAH homologues capable of metabolizing plant endogenous N-acylethanolamines (NAEs).
Gene_expression (express) of FAAH associated with endocannabinoid
2) Confidence 0.78 Published 2008 Journal Planta Med. Section Abstract Doc Link 18275004 Disease Relevance 0.21 Pain Relevance 0.61
Here, we examined the co-expression of the transient receptor potential vanilloid type 1 (TRPV1) and the cannabinoid CB1/CB2 receptors together with N-acylphosphatidylethanolamine-hydrolizing phospholipase D (NAPE-PLD) and fatty acid amide hydrolase (FAAH), the two enzymes responsible of the synthesis and catabolism of anandamide respectively, in human osteoclasts.
Spec (examined) Gene_expression (co-expression) of FAAH in osteoclasts associated with cannabinoid
3) Confidence 0.74 Published 2009 Journal Bone Section Abstract Doc Link 19059369 Disease Relevance 0.10 Pain Relevance 0.23
Here, we examined the co-expression of the transient receptor potential vanilloid type 1 (TRPV1) and the cannabinoid CB1/CB2 receptors together with N-acylphosphatidylethanolamine-hydrolizing phospholipase D (NAPE-PLD) and fatty acid amide hydrolase (FAAH), the two enzymes responsible of the synthesis and catabolism of anandamide respectively, in human osteoclasts.
Spec (examined) Gene_expression (co-expression) of fatty acid amide hydrolase in osteoclasts associated with cannabinoid
4) Confidence 0.74 Published 2009 Journal Bone Section Abstract Doc Link 19059369 Disease Relevance 0.10 Pain Relevance 0.23
Co-expression of TRPV1, CB1/CB2, NAPE-PLD and FAAH was found in both human osteoclast cultures and in native osteoclasts from human bone biopsies.
Gene_expression (Co-expression) of FAAH in osteoclasts
5) Confidence 0.74 Published 2009 Journal Bone Section Abstract Doc Link 19059369 Disease Relevance 0.08 Pain Relevance 0.24
In an additional experiment, PC-3 cells were treated with IL-4 (5 ng/ml) for 3 h, to study possible early regulation of FAAH expression.
Gene_expression (expression) of FAAH in PC-3
6) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0.61 Pain Relevance 0
Here we have investigated the expression of the endocannabinoid metabolising enzyme fatty acid amide hydrolase (FAAH) in a well characterised tissue microarray from patients diagnosed with prostate cancer at transurethral resection for voiding problems.


Gene_expression (expression) of fatty acid amide hydrolase associated with endocannabinoid, overactive bladder and prostate cancer
7) Confidence 0.72 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2924377 Disease Relevance 0.84 Pain Relevance 0.10
Here we have investigated the expression of the endocannabinoid metabolising enzyme fatty acid amide hydrolase (FAAH) in a well characterised tissue microarray from patients diagnosed with prostate cancer at transurethral resection for voiding problems.


Gene_expression (expression) of FAAH associated with endocannabinoid, overactive bladder and prostate cancer
8) Confidence 0.72 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2924377 Disease Relevance 0.85 Pain Relevance 0.10
However, transfection of PC-3 cells with FAAH does increase their rate of 2-AG hydrolysis in addition to the effects on AEA hydrolysis [12].
Gene_expression (transfection) of FAAH in PC-3
9) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0.35 Pain Relevance 0.08
The relative expression of FAAH and CB1was calculated from Ct values using the standard curve method.


Gene_expression (expression) of FAAH
10) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0 Pain Relevance 0.04
This is important in itself, since it would suggest that the two measures are independent, and that a high CB1IR is not a homeostatic consequence of a low endocannabinoid signalling secondary to a high FAAH expression.
Gene_expression (expression) of FAAH associated with endocannabinoid
11) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0.69 Pain Relevance 0.08
Endogenous ethanolamides (fatty acid amides), including arachidonyl ethanolamide (anandamide, AEA), oleoyl ethanolamide (OEA), and palmitoyl ethanolamide (PEA), are substrates of fatty acid amide hydrolase (FAAH).
Gene_expression (substrates) of FAAH
12) Confidence 0.68 Published 2010 Journal J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. Section Abstract Doc Link 20462810 Disease Relevance 0.38 Pain Relevance 0.14
Endogenous ethanolamides (fatty acid amides), including arachidonyl ethanolamide (anandamide, AEA), oleoyl ethanolamide (OEA), and palmitoyl ethanolamide (PEA), are substrates of fatty acid amide hydrolase (FAAH).
Gene_expression (substrates) of fatty acid amide hydrolase
13) Confidence 0.68 Published 2010 Journal J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. Section Abstract Doc Link 20462810 Disease Relevance 0.38 Pain Relevance 0.14
Here, we report the successful overexpression of rat and human FAAH as a fusion to the E. coli maltose-binding protein, retaining catalytic properties of native FAAH.
Gene_expression (overexpression) of FAAH
14) Confidence 0.67 Published 2008 Journal Amino Acids Section Abstract Doc Link 17476568 Disease Relevance 0.17 Pain Relevance 0.12
CONCLUSION: The presently developed Pyrosequencing assays allow for quick and reliable detection of FAAH genotypes and may facilitate investigations of FAAH genetic functional associations.


Gene_expression (detection) of FAAH
15) Confidence 0.67 Published 2007 Journal Prostaglandins Other Lipid Mediat. Section Body Doc Link 17991615 Disease Relevance 0 Pain Relevance 0
A MBP-FAAH fusion protein as a tool to produce human and rat fatty acid amide hydrolase: expression and pharmacological comparison.
Gene_expression (expression) of FAAH
16) Confidence 0.67 Published 2008 Journal Amino Acids Section Title Doc Link 17476568 Disease Relevance 0.18 Pain Relevance 0.14
However, the production of high amounts of enzyme is hampered by the known refractiveness of FAAH to overexpression.
Gene_expression (overexpression) of FAAH
17) Confidence 0.67 Published 2008 Journal Amino Acids Section Abstract Doc Link 17476568 Disease Relevance 0.17 Pain Relevance 0.13
The synthesis of these endocannabinoids is catalyzed by the N-acylphosphatidylethanolamine-selective phospholipase D (NAPE-PLD) and the sn-1-selective diacylglycerol lipase (DAGL), whereas their degradation is accomplished by the fatty acid amide hydrolase (FAAH) and the monoglyceride lipase (MGL), respectively.
Gene_expression (accomplished) of fatty acid amide hydrolase associated with endocannabinoid
18) Confidence 0.66 Published 2006 Journal Biochimie Section Abstract Doc Link 16949718 Disease Relevance 0.30 Pain Relevance 0.40
The synthesis of these endocannabinoids is catalyzed by the N-acylphosphatidylethanolamine-selective phospholipase D (NAPE-PLD) and the sn-1-selective diacylglycerol lipase (DAGL), whereas their degradation is accomplished by the fatty acid amide hydrolase (FAAH) and the monoglyceride lipase (MGL), respectively.
Gene_expression (accomplished) of FAAH associated with endocannabinoid
19) Confidence 0.66 Published 2006 Journal Biochimie Section Abstract Doc Link 16949718 Disease Relevance 0.31 Pain Relevance 0.40
No statistical differences in FAAH expression were found between control, acute and quiescent groups.
Gene_expression (expression) of FAAH
20) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731878 Disease Relevance 0.14 Pain Relevance 0.07

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