INT108409

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Context Info
Confidence 0.31
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.49
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (AGT) small molecule metabolic process (AGT) aging (AGT)
extracellular region (AGT) plasma membrane (AGTR2) extracellular matrix organization (AGT)
Anatomy Link Frequency
AT-1 1
AGT (Homo sapiens)
AGTR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 3 95.96 Very High Very High Very High
fibrosis 4 92.00 High High
Enkephalin 1 91.32 High High
agonist 1 90.72 High High
opioid receptor 1 90.40 High High
Dynorphin 1 86.72 High High
Opioid 3 85.96 High High
Inflammation 2 85.68 High High
Kappa opioid receptor 1 85.28 High High
orphanin 1 84.20 Quite High
Disease Link Frequency Relevance Heat
Heart Rate Under Development 24 94.96 High High
Apoptosis 2 92.56 High High
Fibrosis 4 92.00 High High
Hypertrophy 6 91.60 High High
Increased Venous Pressure Under Development 4 88.96 High High
Myocardial Infarction 120 86.48 High High
Atherosclerosis 6 85.88 High High
INFLAMMATION 2 85.68 High High
Cardiovascular Disease 26 83.12 Quite High
Stress 2 76.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of note, blockade of AT1 receptors is also accompanied by an over-stimulation of AT2 receptors by angiotensin II.
angiotensin II Positive_regulation (stimulation) of AT2
1) Confidence 0.31 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788599 Disease Relevance 0.44 Pain Relevance 0.06
Stimulation of the AT2 receptors by angiotensin II is believed to promote biologic effects that are opposite to those of AT1 receptor stimulation.
angiotensin II Positive_regulation (Stimulation) of AT2
2) Confidence 0.31 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788599 Disease Relevance 0.99 Pain Relevance 0.13
The bioactive angiotensin II, known to bind to and stimulate the AT-1 and AT-2 receptors, is converted to angiotensin IV (i.e. angiotensin 3-8) with preference for the AT-4 sites or to angiotensin (1-7), not recognized by any of these receptors.
angiotensin II Positive_regulation (stimulate) of AT-2 in AT-1
3) Confidence 0.04 Published 2003 Journal Curr. Protein Pept. Sci. Section Abstract Doc Link 12570783 Disease Relevance 0.07 Pain Relevance 0.92

General Comments

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