INT10841

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Context Info
Confidence 0.59
First Reported 1980
Last Reported 2010
Negated 8
Speculated 1
Reported most in Body
Documents 101
Total Number 102
Disease Relevance 45.39
Pain Relevance 16.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gh) signal transduction (Gh) mitochondrion (Gh)
extracellular space (Gh) extracellular region (Gh) plasma membrane (Gh)
Anatomy Link Frequency
plasma 14
pituitary 10
brains 6
P-1 4
blood 4
Gh (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 189 100.00 Very High Very High Very High
cytokine 33 100.00 Very High Very High Very High
Somatostatin 592 99.22 Very High Very High Very High
Sumatriptan 20 99.16 Very High Very High Very High
Central nervous system 19 99.16 Very High Very High Very High
noradrenaline 6 99.16 Very High Very High Very High
Migraine 2 99.04 Very High Very High Very High
headache 66 98.24 Very High Very High Very High
withdrawal 34 97.92 Very High Very High Very High
narcan 14 97.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aging 753 100.00 Very High Very High Very High
Syndrome 241 100.00 Very High Very High Very High
Targeted Disruption 188 99.98 Very High Very High Very High
Hyperinsulinism 13 99.96 Very High Very High Very High
Growth Hormone Deficiency 7 99.96 Very High Very High Very High
Salivary Gland Disease 8 99.88 Very High Very High Very High
Obesity 151 99.84 Very High Very High Very High
Pituitary Cancer 89 99.84 Very High Very High Very High
Hypoglycemia 34 99.76 Very High Very High Very High
Multiple System Atrophy 6 99.70 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to other studies, this study shows no sustained increases in GH production or in improved growth velocity with long-term administration of a single daily dose of clonidine.
Neg (no) Positive_regulation (increases) of Gene_expression (production) of GH associated with clonidine
1) Confidence 0.59 Published 1988 Journal Lancet Section Abstract Doc Link 2902319 Disease Relevance 0.07 Pain Relevance 0.59
In this context, it is of interest that transgenic mice with grossly elevated levels of GH and IGF-1 due to overexpression of different GH genes are short-lived and express various symptoms of accelerated aging (Bartke 2003).


Positive_regulation (elevated) of Gene_expression (levels) of GH associated with targeted disruption and aging
2) Confidence 0.50 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682398 Disease Relevance 0.91 Pain Relevance 0
In this context, it is of interest that transgenic mice with grossly elevated levels of GH and IGF-1 due to overexpression of different GH genes are short-lived and express various symptoms of accelerated aging (Bartke 2003).


Positive_regulation (overexpression) of Gene_expression (overexpression) of GH associated with targeted disruption and aging
3) Confidence 0.50 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682398 Disease Relevance 0.91 Pain Relevance 0
RESULTS: All six patients treated with fluoxetine and two of the six patients given placebo demonstrated an increase in their dexamethasone-induced GH responses.
Positive_regulation (increase) of Gene_expression (responses) of GH
4) Confidence 0.50 Published 1995 Journal Am J Psychiatry Section Body Doc Link 7694914 Disease Relevance 0 Pain Relevance 0
Headaches can also occur as premenstrual migraine or as water retention due to glucocorticoid or Growth Hormone (GH) overdosage.
Positive_regulation (overdosage) of Gene_expression (overdosage) of Growth Hormone associated with pressure and volume under development, migraine and headache
5) Confidence 0.49 Published 2004 Journal Pediatr Endocrinol Rev Section Abstract Doc Link 16437026 Disease Relevance 0.74 Pain Relevance 0.45
Headaches can also occur as premenstrual migraine or as water retention due to glucocorticoid or Growth Hormone (GH) overdosage.
Positive_regulation (overdosage) of Gene_expression (overdosage) of GH associated with pressure and volume under development, migraine and headache
6) Confidence 0.49 Published 2004 Journal Pediatr Endocrinol Rev Section Abstract Doc Link 16437026 Disease Relevance 0.73 Pain Relevance 0.45
The first spontaneous GH peak appeared 26-28 h after GH injection, peak amplitude was 10-15 micrograms/l.
Positive_regulation (after) of Gene_expression (injection) of GH
7) Confidence 0.46 Published 1991 Journal Horm. Res. Section Abstract Doc Link 1806474 Disease Relevance 0 Pain Relevance 0.21
As discussed above, epidemiological studies have clearly demonstrated that controlling GH and IGF-I secretion is the most significant determinant of restoring survival in patients with acromegaly The main goal of treatment of acromegaly is therefore to achieve GH levels of less than 1 ?
Positive_regulation (achieve) of Gene_expression (levels) of GH associated with acromegaly
8) Confidence 0.44 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721386 Disease Relevance 0.68 Pain Relevance 0
[Variability of growth hormone response to repeated stimulation tests in children of normal height].
Positive_regulation ([Variability) of Gene_expression (response) of growth hormone
9) Confidence 0.43 Published 1994 Journal Medicina (B Aires) Section Title Doc Link 7658999 Disease Relevance 0.17 Pain Relevance 0.07
Our results show that all conventional stimuli of GH secretion frequently failed to increase GH levels, showing values lower than that arbitrarily assumed, so far, as minimum normal GH peak, i.e. 7 or 10 micrograms/L.
Neg (failed) Positive_regulation (increase) of Gene_expression (levels) of GH
10) Confidence 0.42 Published 1996 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8784091 Disease Relevance 0.23 Pain Relevance 0.21
IGF-1 overexpression—though not directly comparable to systemically elevated IGF-1/GH levels—has been reported to lead to markedly increased brain size in mice [22], whereas IGF-1 knockout mice showed smaller brains [15].
Positive_regulation (elevated) of Gene_expression (overexpression) of GH in brains associated with targeted disruption
11) Confidence 0.42 Published 2008 Journal Pituitary Section Body Doc Link PMC2712618 Disease Relevance 0.34 Pain Relevance 0.06
IGF-1 overexpression—though not directly comparable to systemically elevated IGF-1/GH levels—has been reported to lead to markedly increased brain size in mice [22], whereas IGF-1 knockout mice showed smaller brains [15].
Positive_regulation (overexpression) of Gene_expression (overexpression) of GH in brains associated with targeted disruption
12) Confidence 0.42 Published 2008 Journal Pituitary Section Body Doc Link PMC2712618 Disease Relevance 0.34 Pain Relevance 0.06
These results demonstrate the potential for night-to-night variation in overnight GH profiles and suggest the need for some means of confirming that overnight GH testing reflects normal physiologic GH secretion.
Positive_regulation (variation) of Gene_expression (profiles) of GH
13) Confidence 0.42 Published 1989 Journal J. Pediatr. Section Abstract Doc Link 2738795 Disease Relevance 0 Pain Relevance 0.22
Ten patients (seven women, three men) with active acromegaly, five previously treated and five newly diagnosed, were included in an open-label prospective trial of 3 daily subcutaneous injections of the long-acting somatostatin analogue SMS 201-995 (Sandostatin) at increasing doses in order to obtain maximum growth hormone (GH) suppression.
Positive_regulation (increasing) of Gene_expression (suppression) of growth hormone associated with acromegaly and somatostatin
14) Confidence 0.41 Published 1990 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 2200620 Disease Relevance 0.29 Pain Relevance 0.18
Ten patients (seven women, three men) with active acromegaly, five previously treated and five newly diagnosed, were included in an open-label prospective trial of 3 daily subcutaneous injections of the long-acting somatostatin analogue SMS 201-995 (Sandostatin) at increasing doses in order to obtain maximum growth hormone (GH) suppression.
Positive_regulation (increasing) of Gene_expression (suppression) of GH associated with acromegaly and somatostatin
15) Confidence 0.41 Published 1990 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 2200620 Disease Relevance 0.29 Pain Relevance 0.18
Acromegaly is characterized by excessive levels of growth hormone (GH) and insulin-like-growth factor 1 (IGF-1) that are caused by pituitary adenomas in most cases.
Positive_regulation (caused) of Gene_expression (levels) of growth hormone in pituitary associated with acromegaly and pituitary cancer
16) Confidence 0.39 Published 2008 Journal Pituitary Section Body Doc Link PMC2712618 Disease Relevance 0.71 Pain Relevance 0
Similarly to other organ systems, the central nervous system may be affected by long-term exposure to increased levels of GH and IGF-1, however, no in vivo studies on brain structure (or metabolism) in acromegaly have been reported to our knowledge.
Positive_regulation (increased) of Gene_expression (levels) of GH in brain structure associated with acromegaly and central nervous system
17) Confidence 0.39 Published 2008 Journal Pituitary Section Body Doc Link PMC2712618 Disease Relevance 0.44 Pain Relevance 0.05
Rather, targeting excessive GH production, muting the GH signal at its receptor, was a totally different approach.
Positive_regulation (targeting) of Gene_expression (production) of GH
18) Confidence 0.38 Published 2006 Journal International Journal of Nanomedicine Section Abstract Doc Link PMC2676637 Disease Relevance 0.40 Pain Relevance 0.12
Acquired GH deficiency in the human leads to a characteristic syndrome, which can be treated successfully with physiological replacement therapy (Janssen et al 1997).
Positive_regulation (leads) of Gene_expression (deficiency) of GH associated with syndrome
19) Confidence 0.38 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676637 Disease Relevance 0.52 Pain Relevance 0
Detailed studies of GH secretion in acromegaly have demonstrated increased basal GH production, increased pulse frequency, disturbed diurnal secretion and decreased regularity (Figure 2) (Ho and Weisberger 1994; van den Berg et al 1994).
Positive_regulation (increased) of Gene_expression (production) of GH associated with acromegaly
20) Confidence 0.38 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676637 Disease Relevance 1.98 Pain Relevance 0.11

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