INT10842

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.64
First Reported 1980
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 18
Total Number 18
Disease Relevance 2.94
Pain Relevance 4.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gh) signal transduction (Gh) mitochondrion (Gh)
extracellular space (Gh) extracellular region (Gh) plasma membrane (Gh)
Anatomy Link Frequency
pituitary 5
somatotroph 2
muscle 1
Gh (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 33 99.82 Very High Very High Very High
dexamethasone 9 99.72 Very High Very High Very High
agonist 33 99.04 Very High Very High Very High
anesthesia 2 99.00 Very High Very High Very High
Somatostatin 67 94.16 High High
Fibrositis 7 93.88 High High
antagonist 22 91.28 High High
dopamine receptor 1 90.84 High High
Neurotransmitter 6 75.00 Quite High
Pain 4 73.64 Quite High
Disease Link Frequency Relevance Heat
Syndrome 146 98.96 Very High Very High Very High
Obesity 15 94.04 High High
Sleep Disorders 6 93.88 High High
Adenoma 23 93.64 High High
Cancer 29 91.44 High High
Cushing's Syndrome /

Hypercortisolism

10 86.48 High High
Prolactinoma 2 85.64 High High
Growth Hormone Deficiency 4 85.60 High High
Congenital Anomalies 8 84.40 Quite High
Galactorrhea 5 84.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although no significant GH release was observed after dexamethasone or clonidine in GH deficiency, an increase in GH after GH-releasing hormone was seen (6.1 +/- 1.9 micrograms/l).
Transcription (observed) of GH associated with dexamethasone and clonidine
1) Confidence 0.64 Published 1997 Journal Horm. Res. Section Abstract Doc Link 9195203 Disease Relevance 0 Pain Relevance 0.51
The hypothalamic stimulatory growth hormone-releasing hormone (GHRH) stimulates GH gene transcription, GH-cell proliferation, and GH release.
Transcription (transcription) of GH
2) Confidence 0.52 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676637 Disease Relevance 0.16 Pain Relevance 0.09
The hypothalamic stimulatory growth hormone-releasing hormone (GHRH) stimulates GH gene transcription, GH-cell proliferation, and GH release.
Transcription (transcription) of GH
3) Confidence 0.52 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676637 Disease Relevance 0.16 Pain Relevance 0.09
In the GH deficiency group, maximum GH levels after clonidine stimulation ranged from <0.1 to 2.1 micro g/l (0.56 +/- 0.58 micro g/l).
Transcription (levels) of GH
4) Confidence 0.51 Published 2003 Journal Horm. Res. Section Body Doc Link 12714786 Disease Relevance 0 Pain Relevance 0
Glucocorticoids (GCs) play a key role in the physiology of the hypothalamic-somatotroph axis, since these steroids enhance growth hormone (GH) gene transcription and increase GHRH receptor synthesis.
Transcription (transcription) of GH in somatotroph
5) Confidence 0.39 Published 1995 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 7626468 Disease Relevance 0 Pain Relevance 0.04
Glucocorticoids (GCs) play a key role in the physiology of the hypothalamic-somatotroph axis, since these steroids enhance growth hormone (GH) gene transcription and increase GHRH receptor synthesis.
Transcription (transcription) of enhance growth hormone in somatotroph
6) Confidence 0.34 Published 1995 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 7626468 Disease Relevance 0 Pain Relevance 0.04
Bromocriptine enhanced GH mRNA content and potentiated the GHRH (10(-8) M)-stimulated content of GH mRNA, while CLON had no effect on GH mRNA.
Transcription (content) of GH associated with clonidine
7) Confidence 0.31 Published 1994 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 7938032 Disease Relevance 0 Pain Relevance 0.77
Since our recent studies have shown that PACAP can induce GH secretion in carp pituitary cells through cAMP/PKA- and Ca2+/calmodulin-dependent mechanisms, these results, taken together, suggest that alpha2-adrenergic stimulation in the carp pituitary may inhibit PACAP-induced GH release and GH gene transcription by blocking the AC/cAMP/PKA pathway and Ca2+ entry through L-type VSCC.
Transcription (transcription) of GH in pituitary
8) Confidence 0.26 Published 2007 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 17311897 Disease Relevance 0 Pain Relevance 0.22
GH levels after clonidine were blunted in all subjects but one AD patient, probably due to an age-dependent attenuation frequently observed in subjects over 45 years of age.
Transcription (levels) of GH associated with clonidine
9) Confidence 0.26 Published 1992 Journal Neurobiol. Aging Section Abstract Doc Link 1522942 Disease Relevance 0.15 Pain Relevance 0.28
In parallel experiments, clonidine reduced GH primary transcript and GH promoter activity without affecting GH mRNA stability, and these inhibitory actions were mimicked by inhibiting adenylate cyclase (AC), blocking protein kinase A (PKA), removing extracellular Ca2+ in the culture medium, or inactivating L-type voltage-sensitive Ca2+ channels (VSCC).
Transcription (transcript) of GH associated with clonidine
10) Confidence 0.25 Published 2007 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 17311897 Disease Relevance 0 Pain Relevance 0.31
Since our recent studies have shown that PACAP can induce GH secretion in carp pituitary cells through cAMP/PKA- and Ca2+/calmodulin-dependent mechanisms, these results, taken together, suggest that alpha2-adrenergic stimulation in the carp pituitary may inhibit PACAP-induced GH release and GH gene transcription by blocking the AC/cAMP/PKA pathway and Ca2+ entry through L-type VSCC.
Transcription (transcription) of GH in pituitary
11) Confidence 0.25 Published 2007 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 17311897 Disease Relevance 0 Pain Relevance 0.22
As steady-state levels of lanreotide were achieved after 3–4 injections [20], the proportion of patients with mean GH ? 
Transcription (proportion) of GH
12) Confidence 0.20 Published 2009 Journal Pituitary Section Body Doc Link PMC2807598 Disease Relevance 0.17 Pain Relevance 0.07
Through activation of pituitary alpha2-adrenoreceptors, NE or the alpha2-agonist clonidine reduced both basal and PACAP-induced GH release and GH mRNA expression.
Transcription (expression) of GH in pituitary associated with agonist and clonidine
13) Confidence 0.19 Published 2007 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 17311897 Disease Relevance 0 Pain Relevance 0.32
Through activation of pituitary alpha2-adrenoreceptors, NE or the alpha2-agonist clonidine reduced both basal and PACAP-induced GH release and GH mRNA expression.
Transcription (expression) of GH in pituitary associated with agonist and clonidine
14) Confidence 0.19 Published 2007 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 17311897 Disease Relevance 0 Pain Relevance 0.32
The mean peak serum GH concentration after GHRH was blunted in GH-deficient children (9.1 +/- 1.7 ng/ml) compared to those in GHND (32.9 +/- 8.5 ng/ml) and normal (43.2 +/- 6.4 ng/ml) children (P less than 0.01).
Transcription (concentration) of GH
15) Confidence 0.12 Published 1986 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 3018032 Disease Relevance 0 Pain Relevance 0.27
During adolescence, the growth rate declines due in part to inefficient testosterone and estrogen levels, resulting in the absence of the pubertal growth spurt.9,108 Long-term GH therapy in patients with PWS has been shown to increase: height velocity and final adult height potential, lean body mass, muscle strength, and level of activity, and to decrease fat mass.109–114 As a result of decreased fat mass and increased lean body mass, GH treatment has also shown to improve pulmonary function in children with PWS.111,115 While the benefits of GH therapy are well documented, the behavioral and cognitive implications of GH treatment are not as unequivocal in the PWS population.
Neg (absence) Transcription (absence) of GH in muscle associated with cognitive disorder and syndrome
16) Confidence 0.12 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2874334 Disease Relevance 1.05 Pain Relevance 0
Other pituitary hormones, with the exception of GH, which increased during anesthesia and operation, exhibited no acute changes.
Neg (exception) Transcription (exception) of GH in pituitary associated with anesthesia
17) Confidence 0.08 Published 1980 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 6766667 Disease Relevance 0.51 Pain Relevance 0.29
With exception of GH, these conclusions are based on studies in small samples.
Neg (exception) Transcription (exception) of GH
18) Confidence 0.07 Published 2002 Journal Rheum. Dis. Clin. North Am. Section Abstract Doc Link 12122926 Disease Relevance 0.57 Pain Relevance 0.28

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox