INT108433

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Context Info
Confidence 0.57
First Reported 2003
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 16
Total Number 20
Disease Relevance 14.15
Pain Relevance 2.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
brain 3
lung 3
Mat1a (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 84 100.00 Very High Very High Very High
monoamine 9 100.00 Very High Very High Very High
cocaine 12 99.68 Very High Very High Very High
lidocaine 15 99.66 Very High Very High Very High
local anesthetic 12 97.56 Very High Very High Very High
cerebral cortex 26 96.96 Very High Very High Very High
agonist 55 94.00 High High
Dopamine 3 75.20 Quite High
Hippocampus 49 69.60 Quite High
cytokine 34 67.64 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 90 100.00 Very High Very High Very High
Aging 211 99.96 Very High Very High Very High
Disease 538 99.58 Very High Very High Very High
Convulsion 33 99.52 Very High Very High Very High
Coronavirus Infection 140 99.44 Very High Very High Very High
Infection 215 99.42 Very High Very High Very High
Severe Acute Respiratory Syndrome 190 99.36 Very High Very High Very High
Sprains And Strains 25 99.20 Very High Very High Very High
Death 16 97.04 Very High Very High Very High
Respiratory Disease 15 92.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Repeated administration of subconvulsive doses of meprylcaine as well as cocaine, both of which inhibit MAT, but not lidocaine, which does not inhibit MAT, increased seizure activity and produced sensitization to other local anesthetics.
Negative_regulation (inhibit) of MAT associated with convulsion, lidocaine, local anesthetic and cocaine
1) Confidence 0.57 Published 2003 Journal Brain Res. Section Abstract Doc Link 12573515 Disease Relevance 0.47 Pain Relevance 0.83
The involvement of chronic inhibition of monoamine transporters (MAT) in the brain with respect to sensitization to cocaine- and local anesthetic-induced seizures was studied in mice.
Negative_regulation (inhibition) of MAT in brain associated with convulsion, local anesthetic, cocaine and monoamine
2) Confidence 0.50 Published 2003 Journal Brain Res. Section Abstract Doc Link 12573515 Disease Relevance 0.31 Pain Relevance 0.63
In addition they measured the synthesis of AdoMet by adenosyl transferase and AdoMet utilization by COMT, and concluded that the decrease in AdoMet levels was a consequence of increased utilization during aging.
Negative_regulation (decrease) of AdoMet associated with aging
3) Confidence 0.44 Published 2009 Journal Neurol Sci Section Body Doc Link PMC2746292 Disease Relevance 0.63 Pain Relevance 0.03
Repeated administration of subconvulsive doses of meprylcaine as well as cocaine, both of which inhibit MAT, but not lidocaine, which does not inhibit MAT, increased seizure activity and produced sensitization to other local anesthetics.
Negative_regulation (inhibit) of MAT associated with convulsion, lidocaine, local anesthetic and cocaine
4) Confidence 0.36 Published 2003 Journal Brain Res. Section Abstract Doc Link 12573515 Disease Relevance 0.48 Pain Relevance 0.89
However, we did observe a significant decrease in AdoMet levels in 15-month-old wild-type mice compared to APP/PS1 mice (Fig. 1a; F(1,45) = 7.54, p < 0.01).
Negative_regulation (decrease) of AdoMet
5) Confidence 0.33 Published 2009 Journal Neurol Sci Section Body Doc Link PMC2746292 Disease Relevance 0.13 Pain Relevance 0
Thus, AdoHcy decreased in both wild type and APP/PS1 mice during aging, whereas AdoMet only decreased in wild-type mice.
Negative_regulation (decreased) of AdoMet associated with aging
6) Confidence 0.33 Published 2009 Journal Neurol Sci Section Body Doc Link PMC2746292 Disease Relevance 0.61 Pain Relevance 0
Stramentinoli et al. found decreased AdoMet levels in brain tissue of aging rats [33].
Negative_regulation (decreased) of AdoMet in brain associated with aging
7) Confidence 0.33 Published 2009 Journal Neurol Sci Section Body Doc Link PMC2746292 Disease Relevance 0.66 Pain Relevance 0
The decrease in AdoMet and AdoHcy found in our wild-type mice could also be the consequence of increased utilization.
Negative_regulation (decrease) of AdoMet
8) Confidence 0.33 Published 2009 Journal Neurol Sci Section Body Doc Link PMC2746292 Disease Relevance 0.64 Pain Relevance 0.03
The finding that AdoMet levels in APP/PS1 mice are not decreased during aging (in contrast to wild-type mice), is probably related to less demand due to neurodegeneration.
Neg (not) Negative_regulation (decreased) of AdoMet associated with aging
9) Confidence 0.33 Published 2009 Journal Neurol Sci Section Abstract Doc Link PMC2746292 Disease Relevance 0.66 Pain Relevance 0
During aging, AdoMet levels decreased in the brains of wild-type mice, whereas AdoHcy levels diminished in both wild type and APP/PS1 mice.
Negative_regulation (decreased) of AdoMet in brains associated with aging
10) Confidence 0.33 Published 2009 Journal Neurol Sci Section Abstract Doc Link PMC2746292 Disease Relevance 0.68 Pain Relevance 0
In this study we showed that AdoMet tissue levels did not differ between 8-month-old APP/PS1 mice and wild-type littermates, but are decreased in 15-month-old wild-type mice compared to APP/PS1 mice.
Neg (not) Negative_regulation (decreased) of AdoMet
11) Confidence 0.33 Published 2009 Journal Neurol Sci Section Body Doc Link PMC2746292 Disease Relevance 0.67 Pain Relevance 0
A significant decrease in AdoMet levels during aging was only found in wild-type mice (F(1,42) = 8.09, p < 0.01) and not in APP/PS1 mice.
Negative_regulation (decrease) of AdoMet associated with aging
12) Confidence 0.33 Published 2009 Journal Neurol Sci Section Body Doc Link PMC2746292 Disease Relevance 0.60 Pain Relevance 0
Although the authors carefully matched with respect to postmortem time the results of this study might be difficult to interpret, since AdoMet levels decrease with more than 60% and AdoHcy levels increase with 80% within 15 h after death [25].
Negative_regulation (decrease) of AdoMet associated with death
13) Confidence 0.33 Published 2009 Journal Neurol Sci Section Body Doc Link PMC2746292 Disease Relevance 0.84 Pain Relevance 0
Moreover, tissue levels of AdoHcy decreased in both wild type and APP/PS1 mice during aging, whereas AdoMet only decreases in wild-type mice.
Negative_regulation (decreases) of AdoMet associated with aging
14) Confidence 0.33 Published 2009 Journal Neurol Sci Section Body Doc Link PMC2746292 Disease Relevance 0.63 Pain Relevance 0
After 24 h, there was a decrease of AMs (CD11c+CD11b?
Negative_regulation (decrease) of AMs
15) Confidence 0.24 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2762542 Disease Relevance 0.72 Pain Relevance 0.03
Here, we demonstrate that lethal disease in mice infected with a mouse-adapted strain of SARS-CoV (MA15) can be prevented if AMs with anti-inflammatory properties are depleted from the lung prior to infection.
Negative_regulation (depleted) of AMs in lung associated with coronavirus infection, inflammation, severe acute respiratory syndrome, sprains and strains, disease and infection
16) Confidence 0.18 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2762542 Disease Relevance 1.84 Pain Relevance 0.17
Further, lethal disease can be prevented if AMs with anti-inflammatory properties are depleted from lungs prior to infection.
Negative_regulation (depleted) of AMs in lungs associated with inflammation, disease and infection
17) Confidence 0.18 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2762542 Disease Relevance 1.96 Pain Relevance 0.09
S5) and were not significantly downregulated after infection (Fig. 4 A), indicating that AMs continued to be inhibitory even after the onset of the infection.
Negative_regulation (inhibitory) of AMs associated with infection
18) Confidence 0.18 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2762542 Disease Relevance 0.45 Pain Relevance 0
By 48 h, approximately 90% of AMs in the lung were depleted (Fig.
Negative_regulation (depleted) of AMs in lung
19) Confidence 0.18 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2762542 Disease Relevance 0.79 Pain Relevance 0
MAT2B increases the level of product inhibition of the MAT holoenzyme [19,20].
Negative_regulation (inhibition) of MAT holoenzyme
20) Confidence 0.04 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.35 Pain Relevance 0.12

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